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Background. Anti-glomerular basement membrane (anti-GBM) disease often results in end-stage renal failure despite therapy with plasma exchange and immunosuppressive drugs. The newly discovered streptococcal enzymes IgG-degrading enzyme of S.pyogenes (IdeS) and endoglycosidase S (EndoS) act with remarkable specificity on circulating IgG. In this study, we investigate their ability in vivo to preven

The function of cultured mast cells may depend on genetic or environmental influence on the stem cell donor. This study investigates whether asthma or atopy in the donor influenced the growth and sensitivity of mast cells cultured from patients with asthma and healthy controls under identical conditions. Mast cells were cultured from peripheral blood from twelve patients with an objectively confir

Pareto optimality is a concept that formalises the trade-off between a given set of mutually contradicting objectives. A solution is said to be Pareto optimal when it is not possible to improve one objective without deteriorating at least one of the other. A set of Pareto optimal solutions constitute the Pareto front. The Pareto concept applies well to the inverse planning process, which involves

This thesis is an extension to the previous work done at Department of EIT in investigating the complexity reduction of LDPC decoding using the stochastic approximation method to improve the energy efficiency of energy-limited applica- tions, such as in mobile phones. The research carried out in this thesis investigates the complexity and conver- gence results of adaptive performance control algorit

Introduction: Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)-derived LZC and MSE differences between responder

Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h

Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat

Introduction: Due to the high cost and complexity, the oral glucose tolerance test is not adopted as the screening method for identifying diabetes patients, which leads to the misdiagnosis of patients with isolated post-challenge hyperglycemia (IPH), that is., patients with normal fasting plasma glucose (<7.0 mmoL/L) and abnormal 2-h postprandial blood glucose (≥11.1 mmoL/L). We aimed to develop a

Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) c

In research on Birka strong focus has since long been directed towards long-distance contacts with Western as well with and Northeastern Europe (todays Russia, Belarus and Ukraine). The great attention paid to west- and east European contacts has likely contributed to that contacts with Finland have fallen out of the discussions. However as seen from studies of the pottery in Birka the Baltic Finn

Keynote paper The point of departure for this lecture lies in the insight that tourism research is uniquely positioned at the juncture of applied and scholarly research. Drawing upon work I have conducted in the realms tourism and leisure study, the lecture strives to problematize the practice of ethnography as a method and raise questions concerning the opportunity research in the fields of tour

Socially Engaged Buddhism: Faith‐inspired drivers of social and political change Chair & introduction. Monica Lindberg Falk, Centre for East and South-East Asian Studies, Lund University, Sweden. This session invites paper that address issues related to socially engaged Buddhism. The Buddhist institutions have always been important actors in society; however, the monks’ and the nuns’ roles h

Examensarbetets titel: Bland Kulturvetare, Småpåvar och Heliga kor: en Kvalitativ Fallstudie om Organisatoriska Värderingars Dynamik och Tvetydighet Seminariedatum: 2017-06-01 Ämne/kurs: FEKH49, Examensarbete i organisation på kandidatnivå, 15 högskolepoäng Författare: Jimmy Björklund, Andreas Jansson och Adrian Schmidt Handledare: Devrim Göktepe-Hultén Nyckelord: Organisatoriska Värderingar, OrgaTitle: Among Cultural Know-it-alls, Micro-popes and Sacred cows: A Qualitative Case Study of the Dynamics and Ambiguity of Organizational Values Seminar date: 2017-06-01 Course: FEKH49, Bachelor Degree Project in Organization Undergraduate level, 15 University Credit Points Authors: Jimmy Björklund, Andreas Jansson and Adrian Schmidt Advisor: Devrim Göktepe-Hultén Keywords: Organizational Values,

Climate change poses an immediate challenge to every actor in society. In this rapidly changing context, organizations are faced with a need to make structural changes to their business strategy and operations as current business models are challenged. Communication is a vital aspect and determinant of organizational change. The purpose of this study has been to examine how an organization communi