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Surrogate measures of safety (SMoS) are meant to function as tools to investigate traffic safety. The term surrogate indicates that these measures do not rely on crash data; instead, they focus on identifying safety critical events (or near-crashes) in traffic, which can be used as an alternative to crash records. The overall aim of this thesis is to explore which SMoS are suitable when analysing

Background/Purpose: The aim of this study was to estimate the incidence rate and prevalence of coronary artery diseases (CAD) in patients with temporal artery positive giant cell arteritis (TAB+GCA) from a defined population in southern Sweden, and to describe characteristics of CAD in this sample.Methods: The study cohort consisted of 1202 patients (71.9% women) diagnosed with TAB+GCA between 199

Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. GAGs are normally attached to a core protein as a part of a proteoglycan; however, GAG biosynthesis can be induced by compounds composed of a xylos

The concept of “Sustainable water use” (SWU) aims to assure three pillars of sustainability related to the water sector: the social, environmental, and economical. Industrial development, especially in developing countries, requires an adequate response, as industrial activities are recognized as one of the major sources of water pollution, what leads to deterioration of environmental safety and w

Importance: Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown. Objective: To assess pathologic complete response (pCR) to standard neoadjuvant therapy of combination docetaxel, trastuzumab, and pertuzumab (DTP) vs T-DM1 monotherapy in patients

There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen

Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not i

Before performing 177Lu-DOTATATE therapy for neuroendocrine tumors, somatostatin receptor (SSTR) PET imaging is currently used to confirm sufficient tumor SSTR expression, but it also has potential to be used to personalize treatment by predicting absorbed doses to critical organs. This study aims to validate the predictive capability of SSTR PET in anticipating renal absorbed dose in the first cy

Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr

Importance: Traditional adoption studies examine disorder-to-disorder parent-offspring transmission. The role of parental genetic risk in offspring disorder transmission can capture indirect genetic effects from parental genotype to parental phenotype to offspring risk. Objective: To assess the relative importance of genetic and rearing effects from paternal family genetic risk scores (FGRSs) in 3

Background Pulmonary nodules (PNs) are clinically challenging because differentiation between benign and malignant PNs is not possible at CT detection; recurring CT examinations and invasive procedures are often required in PN follow-up. Purpose To investigate PN prevalence in a middle-aged population and the risk factors associated with these nodules. Materials and Methods In this secondary analy

ej aktuell sthandbok 1 Uppdaterad våren 2021 AUDIONOMPROGRAMMET Studentguide FÖR DIG SOM ÄR NY STUDERANDE: ETT SÄRSKILT VÄLKOMMEN TILL LUNDS UNIVERSITET! Lunds universitet grundades 1666 och har 40 000 studenter på grundläggande och avancerad nivå och drygt 8000 anställda. Det är ett gammalt och stort universitet som hälsar dig välkommen! Universitetet är indelat i områden, fakulteter. Audionompro

https://www.student.med.lu.se/sites/student.med.lu.se/files/2021-06/Studentguide%202021.pdf - 2026-05-25

CONFERENCE ABSTRACTS Lund University Research Conference Knowledge for Sustainable Development 7 November 2023 | Stadshallen, Lund Session 1 - 09:50-10:50 - I Transition from a regional perspective - II The how-to of impact - III Conserving biodiversity Session 2 – 11:20-12:20 - I Climate impact - II Tools for impact - III Air and Water - IIII Halla Steinunn Stefansdottir - Þytur Poster presentati

https://www.sustainability.lu.se/sites/sustainability.lu.se/files/2023-10/Abstract%20Summary%202023.pdf - 2026-05-25

Science Journals — AAAS Xhonneux et al., Sci. Transl. Med. 13, eabd5666 (2021) 31 March 2021 S C I E N C E T R A N S L A T I O N A L M E D I C I N E | R E S E A R C H R E S O U R C E 1 of 15 M E T A B O L I S M Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression Louis-Pascal Xhonneux1,2, Oliver Knight1,2, Åke Lernmark3, Ezio Bonifacio4, William A. Hag

https://www.teddy.lu.se/sites/teddy.lu.se/files/2022-01/130%2009242021_679_130_MP233_Xhonneux_SciTranslMed_2021.pdf - 2026-05-25

Brevmall 1 Approved by the Board of the Faculty of Medicine Reg. no M 2011/942 20 September 2011 Valid from autumn semester 2012 Amended by the Board of the Faculty of Medicine Reg. no M 2012/1590 23 October 2012 Valid from spring semester 2013 Amended by the Board of the Faculty of Medicine Reg. no U 2014/413 2 June 2014 Valid from autumn semester 2015 Amended by the Undergraduate Education Board

https://www.lu.se/sites/www.lu.se/files/vabme-programme-syllabus-autumn-2020-eng.pdf - 2026-05-25

Perspectives on Multi-level Governance, Decentralisation and Human Rights Perspectives on Multi-level Governance, Decentralisation and Human Rights SAYP 2024 | LUND UNIVERSITY | WESTERN BALKANS The Swedish Institute Academy for Young Professionals (SAYP) is a training programme financed and initiated by the Swedish Institute. The SAYP programme Perspectives on Multi-level Governance, Decentralisat

https://www.lunduniversity.lu.se/sites/www.lunduniversity.lu.se/files/2024-03/Perspectives-on-multi-level-governance-decentralisation-and-human-rights-western-balkans-2024.pdf - 2026-05-25

BACKGROUND: Neuronal damage in systemic lupus erythematosus (SLE) is common, but the extent and mechanisms are unclear. Neurofilament light (NfL) concentrations rise in plasma and cerebrospinal fluid (CSF) during neuronal damage in various neurological disorders. In this cross-sectional study, plasma and CSF concentrations of NfL were explored as a marker of neuronal damage in SLE.METHODS: Seventy

Popular Abstract in Swedish Transplantation av dopaminceller från mänskliga foster kan förbättra funktionen hos patienter med Parkinsons sjukdom (Lindvall 1997, Björklund 2000a). Man har kunnat visa att transplantaten har återställt dopaminproduktionen i striatum till normala nivåer i flera fall, och till 70-80% av normalt i majoriteten av de patienter som transplanterats i Lund. Transplantaten haTransplantation of embryonic human neural tissue can restore function in patients with Parkinson’s disease, but there is a severe shortage of donor tissue which limits the applicability of the technique. Embryonic neural tissue from other species, xenogeneic tissue, would provide a readily accessible donor tissue with the potential to help patients if the immunological reactions in the host could

Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (

Context. X-ray extragalactic surveys are ideal laboratories for the study of the evolution and clustering of active galactic nuclei (AGN). Usually, a combination of deep and wide surveys is necessary to create a complete picture of the population. Deep X-ray surveys provide the faint population at high redshift, while wide surveys provide the rare bright sources. Nevertheless, very wide area surve