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barncancer – Sida 2 – Vetenskap och Hälsa

barncancer – Sida 2 – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Etikett: barncancer Canceröverlevares försäkringsskydd har inbyggd slumpgenerator 2012-10-02 I dag lever 80 % av de barn och unga som får cancer minst fem år efter det att sjukdomen konstaterats. Men priset kan vara högt m

https://www.vetenskaphalsa.se/tag/barncancer/page/2/ - 2026-05-31

Age-related loss of proximal femoral strength in elderly men and women: The Age Gene/Environment Susceptibility Study - Reykjavik

The risk of hip fracture rises rapidly with age, and is particularly high in women. This increase in fracture risk reflects both the age-related change in the risk of falling and decrements in the strength of the proximal femur. To better understand the extent to which proximal femoral density, structure and strength change with age as a function of gender, we have carried out a longitudinal analy

Improving outcomes in patients with coronary heart disease using national registers and platelet function testing

Popular Abstract in Swedish Hjärt och kärlsjukdomar utgör idag den vanligaste orsaken till död världen över. I denna avhandling studerades patienter med hjärt-kärlsjukdom inom svenska register för att analysera betydelsen av olika komponenter av behandlingen vid hjärt-kärlsjukdom. Komponenter som utvärderades var tid till primär perkutan (endovaskulär) kranskärlsintervention (PCI), dvs ballongvidgIntroduction: Ischemic heart disease is the leading cause of death worldwide. The aims of this thesis were to evaluate different contemporary approaches in coronary care with regard to mortality and myocardial infarction. Methods: The thesis consists of 6 papers with 4 papers evaluating different exposures and their outcomes (clopidogrel pre-treatment, 5 different anti-platelet protocols, ticagrel

Normalizing to GADPH jeopardises correct quantification of gene expression in ovarian tumours-IPO8 and RPL4 are reliable reference genes

Background: To ensure a correct interpretation of results obtained with quantitative real-time reverse transcription-polymerase chain reaction (RT-qPCR), it is critical to normalize to a reference gene with stable mRNA expression in the tissue of interest. GADPH is widely used as a reference gene in ovarian tumour studies, although lacking tissue-specific stability. The aim of this study was to id

Older non-Nordic immigrants living in Sweden and receiving municipal care

Older immigrants in need of public care will increase in the future. It is therefore important to increase the knowledge of their situation in order to meet their varying care needs. The overall aim of this thesis was to explore the situation of older non-Nordic immigrants, aged 65 years and older, living in Sweden and receiving municipal care with the focus on care provided, care-related needs an

Temperature, size, reproductive allocation, and life-history evolution in a gregarious caterpillar

The present study aimed to investigate the relationship between growth rate, final mass, and larval development, as well as how this relationship influences reproductive trade-offs, in the context of a gregarious life-style and the need to keep an optimal group size. We use as a model two sympatric populations of the pine processionary moth Thaumetopoea pityocampa, which occur in different seasons

High constant incidence rates of second primary cancers of the head and neck: a pooled analysis of 13 cancer registries

Scanty data are available on the incidence (i.e., the absolute risk) of second cancers of the head and neck (HN) and its pattern with age. We investigated this issue using data from a multicentric study of 13 population-based cancer registries from Europe, Canada, Australia and Singapore for the years 1943-2000. A total of 99,257 patients had a first primary HN cancer (15,985 tongue, 22,378 mouth,

Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3.

Signal transduction in response to growth factors is a strictly controlled process with networks of feedback systems, highly selective interactions and finely tuned on-and-off switches. In the context of cancer, detailed signaling studies have resulted in the development of some of the most frequently used means of therapy, with several well established examples such as the small molecule inhibito

Abstract P3-02-02: Concordance between immunohistochemical and gene-expression based subtyping of early breast cancer using core needle biopsies and surgical specimens - experices from SCAN-B

Introduction: Preoperative chemotherapy in early breast cancer increases the rate of breast preservation and provides prognostic information. Treatment decisions in these cases rely on biomarker assessments and subtyping from tissue acquired through core needle biopsies. Tumor heterogeneity and representativity are pit-falls when limited tissue is available. Biomarker expression may change conside

Endometrial cancer off-line staging using two-dimensional transvaginal ultrasound and three-dimensional volume contrast imaging : Intermethod agreement, interrater reliability and diagnostic accuracy

Objectives: The aim is to estimate agreement between two-dimensional transvaginal ultrasound (2D-TVS) and three-dimensional volume contrast imaging (3D-VCI) in diagnosing deep myometrial invasion (MI) and cervical stromal involvement (CSI) of endometrial cancer and to compare the two methods regarding inter-rater reliability and diagnostic accuracy. Methods: Fifteen ultrasound experts assessed off

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From the flashy to the humble - Towerless Medieval Churches in DenmarkThe article investigates a special category of medieval churches, the towerless churches. The Danish concept for “kullet”, meaning bald headed are discussed, an inventory of the towerless churches is established for medieval Denmark, the architecture is analyzed in relation to different ideals and studied from social and economi

'We are Like Water in Their Hands' - experiences of imprisonment in Myanmar

Prisons are institutions through which states exert social control and deprive citizens of rights; where entitlements of citizens are limited to the bare minimum deemed acceptable to a given state. Therefore, prisons are institutions which reveal core aspects of the relation between a state and its citizens. In authoritarian regimes, as Myanmar was in a very recent past, prisons are places in whic

Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity

Background/Aims Prematurely born infants undergo costly, stressful eye examinations to uncover the small fraction with retinopathy of prematurity (ROP) that needs treatment to prevent blindness. The aim was to develop a prediction tool (DIGIROP-Screen) with 100% sensitivity and high specificity to safely reduce screening of those infants not needing treatment. DIGIROP-Screen was compared with four

Cognitive functioning in adolescents with severe obesity undergoing bariatric surgery or intensive non-surgical treatment in Sweden (AMOS2): a multicentre, open-label, randomised controlled trial

Severe obesity during childhood is associated with cognitive deficits. Studies in adults have suggested improvements in executive functioning and memory after bariatric surgery. Our aim was to explore changes in cognitive function in adolescents over two years after bariatric surgery or intensive non-surgical treatment. Methods: The Adolescent Morbid Obesity Surgery 2 (AMOS2) is a multicentre, ope

Multicentre Experience with Novel Bidirectional Double Cuffed Inner Branches for Complex Endovascular Aortic Repair

Objective: This study aimed to report the initial experience with a novel bidirectional double cuff inner branch design for incorporation of renal and mesenteric arteries in patients undergoing fenestrated and branched endovascular aortic repair (F/BEVAR). Methods: A retrospective review was undertaken of the experience of F/BEVAR with grafts integrating at least one bidirectional double cuffed in

Etranacogene dezaparvovec gene therapy for haemophilia B (HOPE-B) : 24-month post-hoc efficacy and safety data from a single-arm, multicentre, phase 3 trial

Background: Etranacogene dezaparvovec, the first gene therapy approved for haemophilia B treatment, was shown to be superior to treatment with continuous prophylactic factor IX in terms of bleeding protection 18 months after gene therapy in a phase 3 trial. We report post-hoc 24-month efficacy and safety data from this trial to evaluate the longer-term effects of etranacogene dezaparvovec in indiv

Epidemiology and etiology of childhood fractures in southern Sweden

Background: As much as 40–50% of children are expected to sustain fractures during growth. A childhood fracture is alsoassociated with high risk of fractures in adult life. Previous research has shown that fracture incidence has not been stable andsome studies suggest that this has also continued during recent decades.Aims: The aim of this thesis was therefore to describe fracture epidemiology and

Protection against cold in prehospital care — thermal insulation properties of blankets and rescue bags in different wind conditions

Introduction: In a cold,wet, or windy environment, cold exposure can be considerable for an injured or ill person. The subsequent autonomous stress response initially will increase circulatory and respiratory demands, and as body core temperature declines, the patient’s condition might deteriorate. Therefore, the application of adequate insulation to reduce cold exposure and prevent body core cool

Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy

Background: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people with COPD and severe chronic hypoxaemia at rest. The efficacy of oxygen therapy for breathlessness and health-related quality of life (HRQOL) in people with COPD and mild or no hypoxaemia who do not meet the criteria for LTOT