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Background: Sharing of data about variation and the associated phenotypes is a critical need, yet variant information can be arbitrarily complex, making a single standard vocabulary elusive and re-formatting difficult. Complex standards have proven too time-consuming to implement. Results: The GEN2PHEN project addressed these difficulties by developing a comprehensive data model for capturing biom
We have experimented with different SOM-based architectures for bio-inspired self-organizing texture and hardness perception systems. To this end we have developed a microphone based texture sensor and a hardness sensor that measures the compression of the material at a constant pressure. We have implemented and successfully tested both monomodal systems for texture and hardness perception, bimoda
First predictions for specific case of the particle-hole-core coupling model which takes advantage of symmetries of a triaxial rotor with gamma = 90 degrees are reviewed. Results of the model calculations point towards existence of stable chiral geometry in specific configurations involving high-j orbitals. Next, experimental information on doublet bands built on unique parity, pi(h)11/2(Vh)11/2 i
Fluorescence techniques for applications in tissue diagnostics and therapy monitoring were investigated and developed in the work presented in this thesis. The aim was to develop fluorescence diagnostics for the detection of malignant tumors and better delimitation of the tumor margins, using the enhanced contrast in fluorescence between tumor and surrounding healthy tissue. Fluorescence may be ge
Hidden Markov models (HMMs) are probabilistic functions of finite Markov chains, or, put in other words, state space models with finite state space. In this paper, we examine subspace estimation methods for HMMs whose output lies a finite set as well. In particular, we study the geometric structure arising from the nonminimality of the linear state space representation of HMMs, and consistency of
In this project the concept of digital power was examined. Though not a new phenomena, the concept was new to Micropower. The company develops a wide array of battery chargers and wanted to include this concept in future generations of their products. The reasoning behind the decision is the possibilities of smoother development, better error handling and more communication. As a first step differ
The development seen within industrial automation in recent years enables the emergence of manufacturing sites that utilise technology for improved productivity, quality and safety. Increased communication demands introduced by Industry 4.0 have motivated the development of cloud-fog automation; a technique characterised by wireless communication between lower levels of the automation pyramid. Spe
Technical development often precedes scientific breakthrough but can also pose new challenges to the scientific community. This is the case for Digital Spatial Profiling (DSP), where recent breakthroughs allow for collecting multi-plex spatial proteomic/transcriptomic data from tissue and it is prophesied a promising future in cancer research. A challenge, however, is handling its output data with
The goal of risk and vulnerability research is to reduce the harm done by disasters. A disaster is a combination of a natural hazard and a vulnerable society. Understanding vulnerability is vital to reduce disaster risk, or the potential of losses in property or life. Vulnerability is often divided into a technical, relating to buildings, infrastructure, and so forth, and a social which concerns t
The Implementation and some mathematical properties of GMRES and weighted GMRES (WGMRES) are described. Numerical experiments originally performed by Essai (1998) are performed to compare the two methods. GMRES and WGMRES are used to solve a linear system arising from the Poisson equation and compared with respect to computational effort.
Alzheimer’s Disease (AD), a neurodegenerative disease, defined by abnormal accumulation of proteins, both extracellularly (senile plaques, consisting of amyloid-beta(Aβ) accumulation) and intracellularly (neurofibrillary tangles, formed by Tau protein). Several studies demonstrate that the immune cells play a central role in the pathogenesis of AD, but it is not known if immune cells from the peri
Machine-learning methods have in recent years seen a great deal of use in condensed matter physics. In this thesis we apply such methods, specifically machine-learning with artificial neural networks, to the equilibrium and non-equilibrium description of the Hubbard and Hubbard-Holstein models. In the framework of ground-state density functional theory we reproduce results from the literature rega
Mesosideriter är sällsynta sten-järnmeteoriter med ett gåtfullt ursprung. Deras ovanliga blandning av skorp- och kärnmaterial har föranlett många bildningsteorier under det senaste århundradet. Några frågor har avsett ursprunget till metallen, huruvida den kom från en annan himlakropp, eller från moderkroppens egen kärna, samt varför det finns så pass lite mantelmaterial. Nedslag har haft en centrMesosiderites are rare stony-iron meteorites with enigmatic origins. Their unusual mix of crustal and core materials have inspired many formation theories over the last century. Some of the outstanding questions have regarded the origin of the metal, whether it came from another celestial body or from within the parent body, and the absence of mantle material. The role of impacts has been central
The Theory of Change (ToC) approach has become popular among the international development community, emerging as a need for organizations to carry out more effective initiatives in the context of an increasingly complex world. The levels at which a ToC process can be aimed are worldwide, organizational, thematic and program or project level. The purpose of this study is to generate a better under
Purpose – The existing literature of open innovation (OI) has focused mainly on large companies and few on SMEs, leaving start-ups with scarce analysis of the use of OI. This paper aims to close that gap and contribute to a better understanding of what drives start-ups to open for innovation, how they use it and comprehend what challenges and benefits OI brings to start-ups. Design/methodology/ap
While industrial robots have traditionally been designed for tasks such as pick-and-place that require a high repeatability, an increasing demand for off-line control and high-precision applications have in recent decades put higher demands on the accuracy of robots. One application in that vain is the detection of X-rays that have been scattered from a sample during X-ray diffraction, which produ
Contactless palmprint recognition is a biometric technology which due to its ease of acquisition, non invasive nature and potentially cheap cost can come to stand competitive to more widely used biometric traits such as finger- or facial recognition. This work uses two different feature extraction methods for palmprint images, the Scale invariant feature transform (SIFT) with an iterative random s
