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This paper provides an overview of a socio-technical toolbox (STT) based on a combination of methods from a number of contemporary socio-technical (ST) methodologies. The STT supports a pragmatic ST approach to organizational change practice and job redesign. It has been developed and used in practice in many different types of organizations over a period of many years. The use in practice of STT
As supply uncertainties and increased lead times were more prominent than ever during the covid-19 pandemic, many companies experienced disrupted supply chains and realized the weaknesses in their inventory management and supply chain planning. Many organizations, including the case company in this thesis, Beijer Ref, experienced the impact of the bullwhip effect on their operations. The bullwhip
Adsorption is an important separation technique in chemical engineering, capable of achieving a high purity of product. As it is also capable of concentrating even very low concentrations it was investigated as a possible method to concentrate the product of an ammonia plasma reactor in the EU DARE2X project. As the development of adsorption systems is expensive and time consuming, a simulation of
PFAS is a group of long-lasting chemicals with multiple known toxicological effects which has been found everywhere in nature. One of the possible source points of PFAS is via landfill through leachate leaving the area. It is therefore important to investigate and implementing remediation techniques to reduce the contamination risk. This thesis focuses on two components, first a literature study w
Early designs are often based on rough estimations and assumptions. Such is also the case when designing space turbines that power rocket engine fuel pumps which generally have obscure performance and size requirements. Often times, this leads to unique, single-use designs. This complicates and restricts the amount of possible testing. To aid in this early design process and to help predict turbin
Modern medicine is rapidly evolving toward personalized treatments, where therapies are tailored to an individual’s genetic profile. This shift is driven by the promise of pharmacogenomics, which aims to match patients with the most effective medications based on their unique biological makeup. As a result, biotherapeutics made from biological sources like proteins, peptides, and antibodies are be
This thesis investigates the integration of the individual learning rates from Rprop into SGD and Adam optimization methods. The individual learning rates are updated separately from the weights. A major focus of this work is the role of mini-batch size in updating these learning rates. Empirical analysis demonstrates that selecting an appropriate mini-batch size can accelerate convergence and imp
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, with limited systemic therapeutic options and high recurrence rates. New treatment modalities in oncology, including antibody-drug conjugates and CAR-T cells, target the tumor cell surfaceome. However, despite extensive genomic and transcriptomic profiling, actionable surface antigens for targeted immunothe
In process industry many control loops are far from optimally tuned. In this master's thesis a tool for rapid process identification and control design has been developed. The tool, which is implemented in Matlab 5.3, identifies a process model out of the step response of the real process. A PI or PID controller can then be designed and evaluated. The tool contains three different automatic de
One problem when new controllers or control systems are built is the test of the controllers or the control systems. One way to test the controller is to build a real process to test the controller against. Another way to test the controller is to build the process-model in some kind of computer simulation tool. The advantages of using a simulation tool in a computer are quite many. For example
Efficient bioconversion of the pentose xylose is vital for the development of competent lignocellulose biorefineries. Although many proper attempts of metabolic engineering for recombinant xylose utilization have been made in Saccharomyces cerevisiae, growth on xylose is still far from being optimal. Previous findings point out a more complex explanation to this feature involving interactions betw
Sandvik SRP has earlier studied a new way of calculating the cost in crushing and screening the results was a satisfactory, Sandvik SRP is now ready to go further in this study. The purpose of this study is further develop of the earlier adopted generic cost model earlier developed by Heyman and Lindström in order to calculate the cost per metric ton within the world of crushing and screening. By
This thesis investigates two ways of incorporating GPUs in Modelica. The first by automatically generating GPU code for Modelica functions, and the second by using GPU accelerated external code for a contact handling package. Automatic parallelization of functions is desired, as it can potentially accelerate large simulations significantly. Special patterns of nested for-loops in Modelica code are
This Master Thesis was made under and in collaboration with Pond Healthcare Innovation for Celgene. Celgene is a global pharmaceutical company developing treatments for cancer and other severe, immune, inflammatory conditions. In March 2015 Celgene launched a new oral treatment called Otezla (effective substance aprimelast) on the Nordic market. With this move they entered the arena of Psoriasis a
In this master thesis, combinations of noise-canceling LNA and harmonic-rejection mixers are investigated and compared to find an optimal inductorless receiver front-end for low-band (600-960MHz) FDD LTE-A network. The work was carried out in a modem development project at Ericsson Modems, Lund. Three receiver versions with different harmonic rejection techniques are compared in terms of noise fig
This thesis is evaluating the pedestrian modelling software Viswalk for the use as a building evacuation model, by verifying and validating the model. In the verification, a procedure from the National Institute of Standards and Technology (NIST) is used as a basis to assess Viswalk’s ability to represent pre-evacuation time, movement and navigation, exit usage, route availability and flow constra
In many application areas in industrial production, industrial robots are utilised for performing various tasks. Frequently a predefined geometric path exists, such that the robot should track this path with its tool centre point. The tracking is often to be performed with certain criteria specified, such as minimisation of time or energy. Accordingly, path tracking problems can often conveniently
The purpose of this Master's Thesis was to compare and coordinate active chassis systems in a search for new ways of controlling two driving situations; side wind exposure and split friction braking. These situations were to be mastered by three active systems; active steering, brakes and suspension. Examples of how to use the systems were presented for each driving situation. The results from
