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UNLABELLED: Herein we present a system to obtain fibers from clickable elastin-like recombinamers (ELRs) that crosslink in situ during the electrospinning process itself, with no need for any further treatment to stabilize them. These ELR-click fibers are completely stable under in vitro conditions. A wrinkled fiber morphology is obtained. In addition to a random fiber orientation, oriented fibers
Climate models have continued to be developed and improved since the AR4, and many models have been extended into Earth System models by including the representation of biogeochemical cycles important to climate change These models allow for policy-relevant calculations such as the carbon dioxide (CO2) emissions compatible with a specified climate stabilization target. In addition, the range of cl
Large language models can transform individuals’ mental health descriptions into scores that correlate with rating scales approaching theoretical upper limits. However, such analyses have combined word- and text responses with little known about their differences. We develop response formats ranging from closed-ended to open-ended: (a) select words from lists, write (b) descriptive words, (c) phra
BACKGROUND AND PURPOSE: Treatment of cancer with immune checkpoint inhibitors (ICIs) entails a risk of immune-related adverse events (irAEs). Data on the treatment of immune-related enterocolitis (irEC) in patients with inadequate symptom control after treatment with standard therapy including corticosteroids, infliximab, and vedolizumab are scarce. Based on limited data, recommendations include t
Machine learning methods have a groundbreaking impact in many application domains, but their application on real robotic platforms is still limited. Despite the many challenges associated with combining machine learning technology with robotics, robot learning remains one of the most promising directions for enhancing the capabilities of robots. When deploying learning-based approaches on real rob
Amplification of the MYCN proto-oncogene serves as a key marker of aggressive disease and poor treatment outcomes in certain pediatric tumors originating from the nervous system, including neuroblastoma and medulloblastoma. However, the complex nature of the challenging MYCN protein underscores the urgent need for additional targets and therapies to tackle neuroblastoma and medulloblastoma. In thi
Background: Opioid use disorder is a chronic disorder with a high risk of overdose-related morbidity and mortality where a large proportion of these can be averted by timely administration of the antidote naloxone. For naloxone to be present when and where overdoses occur, broad-scale overdose education and naloxone distribution (OEND) must be established. A regional naloxone program was implement
The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between “resectable” and “unresectable” disease. Also, the use of preoperative systemic therapy has resulted in an increased frequency of disappearing liver metastasis (DLM). The optimal management of DLM is still controversia
The research evaluated retrofitting options for a threestory church community building in Grevie, Sweden, assessing the impacts on energy efficiency, life cycle cost, and environmental concerns. An energy model was generated in IDA ICE to simulate the building performance. Various improvements were tested in two separate retrofit package scenarios. They had the following measures in common: the ad
Dr Lisbeth NilssonLearning objectives:1. Describe at least three essential aspects of the facilitating approach.2. Explain why these aspects can facilitate optimal outcomes of intervention.3. Evaluate usefulness of the universal facilitating approach in your own practice.Session description:The process of learning joystick-use and training strategies for each phase in the process were identified i
A series of Na0.67Ni0.33Mn0.67-xSnxO2 (x = 0, 0.01, 0.03, 0.05) materials with mixed P2/P3 phases are synthesized with a conventional solid-state reaction method and investigated as cathode materials for sodium ion batteries. The effects of Sn substitution on the structure and electrochemical performance of the Na0.67Ni0.33Mn0.67O2 are systematically investigated. The substituted samples show smal
Nocturia, the urge to wake from sleep to void, is targeted sub-optimally by existing drugs that modulate circadian dysregulation of urine production in kidney without alleviating detrusor overactivity, a key aspect in the multifactorial etiology of nocturia. This study reports age-related upregulation of arginine vasopressin (AVP) synthesis in mouse urinary bladder to counter the concurrent declin
The idea that tunneling is enhanced by the compression of the donor-acceptor distance has attracted significant interest. In particular, recent studies argued that this proposal is consistent with pressure effects on enzymatic reactions, and that the observed pressure effects support the idea of vibrationally enhanced catalysis. However, a careful analysis of the current works reveals serious inco
Background: A juxtarenal abdominal aortic aneurysm is defined as a short (less than 4mm) or no-neck aneurysm, which is often treated with open or complex endovascular repair. The evidence to support the best treatment strategy is scarce. The aim of this study was to assess the short- and mid-term outcomes of elective open surgical repair or fenestrated endovascular aneurysm repair for juxtarenal a
III-Nitride based LEDs based on InGaN active layers on GaN work very well for the blue and green emitting LEDs. However, the large lattice mis-match between redemitting active layers, with at least 35% indium in the active layers, and the GaN substrate still limits the efficiencies obtained to very low values. Unfortunately, the approach to use GaAs based (GaAs/AlInGaP) devices for the red fails f
