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Aims: Recent studies have suggested potential sex differences in treatment response to pharmacological therapies in heart failure (HF). We performed a systematic review and meta-analysis of studies comparing treatment effects between men and women with HF and reduced ejection fraction (HFrEF) using established guideline-directed medical therapy and other emerging pharmacological treatments. Method
Ambisonics fixed media composition. 2020. 14:00. PLEASE NOTE this is a Headphone version. It will not play properly in speakers. Multi-channel speaker versions of the piece are available from the composer on request.
Currently, the AquaCrop model has been widely tested for many fruit/grain crops; root and tuber crops; leafy vegetables, or forage crops, but is restricted to annual herbaceous species, while deciduous crops have received less if no attention. In this context, this study aims to test for the first time the ability of the AquaCrop model to simulate canopy cover (CC), actual evapotranspiration (ETa)
China is urbanizing at an unprecedented rate, but also accelerating the use of water resources and overloading of urban drainage systems. To analyze the impact of urbanization on the drainage-system health in Jinxi, a typical small case area in China, this study proposed an innovative methodological framework for evaluation and prediction based on statistical and modeling methods, which provides a
The objective was to investigate the validity and reliability of a new instrument assessing sexual harassment at a public university in Sweden. In-depth interviews and focus group discussions resulted in a 10-item instrument, the ‘Lund University Sexual Harassment Inventory’ (LUSHI). A survey was sent to all staff, including PhD students, and students, with a response rate of 33% (n = 2736) and 32
In this work, the forestry-enabled dynamic vegetation model LPJ-GUESS was used to simulate forest standing volume for the three main regions of Sweden. At the regional scale, the model results were evaluated against observational data from the Swedish National Forest Inventory. Carbon fluxes of net ecosystem exchange (NEE), gross primary productivity (GPP), and ecosystem respiration (Reco) were si
BackgroundMultigene expression assays for molecular subtypes and biomarkers can aid clinical management of early invasive breast cancer. Based on RNA-sequencing we aimed to develop single-sample predictor (SSP) models for conventional clinical markers, molecular intrinsic subtype and risk of recurrence (ROR).MethodsA uniformly accrued breast cancer cohort of 7743 patients with RNA-sequencing data
Frailty refers to the lack of resilience and a reduction in a person’s ability to recover following a health problem, and it is increasingly becoming a challenging aspect of ageing populations.Many older adults are exposed to polypharmacy; i.e., they continue to be on medications without timely re-evaluation. Medication reviews have proven successful in managing polypharmacy in the general populat
The atmospheres of ultra-hot Jupiters are highly interesting and unique chemical laboratories. Due to the very high atmospheric temperatures, their chemical composition is dominated by atoms and ions instead of molecules, and the formation of aerosols on their day-sides is unlikely. Thus, for these planets detailed chemical characterisations via the direct detection of elements through high-resolu
BACKGROUND: Complete atrioventricular block (CAVB) is a major reason for implantation of permanent pacemakers, but knowledge of CAVB inheritance is sparse. This nationwide study aimed to determine the occurrence of CAVB in first-, second-, and third-degree relatives (full siblings, half-siblings, and cousins).METHODS: The Swedish multigeneration register was linked to the Swedish nationwide patien
Due to their potential environmental risk, the abatement of organic micropollutants from wastewater has gained increasing attention in recent years. This thesis evaluates the use of ozone in Swedish wastewater treatment plants (WWTPs) and the incentives for full-scale implementation of organic micropollutant removal.This work is divided into two sections: the first segment comprises quantitative r
BACKGROUND AND PURPOSEAcquiring and interpreting quantitative myelin-specific MRI data at an individual level is challenging because of technical difficulties and natural myelin variation in the population. To overcome these challenges, we used multiecho T2 myelin water imaging (MWI) to create T2 metric healthy population atlases that depict the mean and variation of myelin water fraction (MWF), a
BackgroundLoss to follow-up (LTFU) from tuberculosis (TB) treatment and care is a major public health problem as patients can be infectious and also may develop a multi-drug resistant TB (MDR-TB). The study aimed to assess whether LTFU differs by the distance TB patients travelled to receive care from the nearest health facility.MethodsA total of 402 patient cards of TB patients who received care
Preventing and mitigating damage to the surroundings arising from process safety incidents is an important aspect of process safety. Risk-informed or risk-based decision-making are cornerstones in most countries’ regulatory regimes for land-use planning. However, the design and implementation of the regulations vary significantly - from countries that have chosen a highly standardized set of rules
Remote sensing (RS) data provide large-scale observations to measure water quality parameters (WQPs) like turbidity (Turb), which indicates the haziness of the water. Accurately estimating these parameters solely from RS data is inherently complex due to various factors, necessitating the use of advanced models capable of capturing the intricate relationships between RS spectral bands as an input
The term “existential” is nowadays used in connection with different kinds of threat, risk and hazard–sustainability discourse included. Loss of certain forms of existence, potential, conditions and values have all been claimed to be incompatible with existential dimensions of sustainability (or “existential sustainability”, for short). In order to clarify the notion(s) of existential sustainabili
A search for high-mass resonances decaying into a Formula Presented-lepton and a neutrino using proton-proton collisions at a center-of-mass energy of Formula Presented is presented. The full run 2 data sample corresponding to an integrated luminosity of Formula Presented recorded by the ATLAS experiment in the years 2015-2018 is analyzed. The Formula Presented-lepton is reconstructed in its hadro
