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The field of organ transplantation is experiencing a transformative shift with the rise of Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell therapies, and tissue-engineered products. These therapies offer new, potentially curative treatments for longstanding medical challenges, impacting numerous patients. However, their adoption is hindered by complex regula
Liquid crystalline nanoparticles (LCNPs), e.g. cubosomes and hexosomes, are receiving more and more attraction as drug delivery vehicles. Dry powder formulation that forms LCNPs upon hydration can be advantageous to make new routes of administration accessible. In this work, we investigate use of three disaccharides (lactose, trehalose and sucrose) as protective matrices for glycerol monooleate ba
The coefficient of friction (COF) and wear are critical parameters in assessing disc brake performance. However, their study is challenging due to their interdependence on contact pressure, sliding velocity, temperature, and material composition. The complex contact interactions between brake pads and discs involve the continuous formation and destruction of mesoscopic contact plateaus, which
Software is at the core of digitalisation and is often claimed to play a central role in innovation and in shaping competition across industries and firms. There are yet few studies of the extent and nature of software development across firms. We employ a unique firm-level survey comprising 3,929 firms across Sweden to analyse the distribution and characteristics of firms that invest in software
In the present work, we describe the design, synthesis, and evaluation of a galectin-8- binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was characterized for its photophysical properties and its binding affinity for galectin-8N was determined by using FP. We evaluated the probe in a competitive FP assay w
Aims: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.Methods: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ Aims: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.Methods: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ
We investigate public managers’ perceptions about the characteristics of global budgets and the association with perceived autonomy, using a qualitative, experiential approach. We compare and contrast differences in managers perceived autonomy associated with the use of global budgets in two large public healthcare organizations, while considering both the characteristics of other control practiceWe investigate public managers' perceptions about the characteristics of global budgets and the association with perceived autonomy, using a qualitative, experiential approach. We compare and contrast differences in managers perceived autonomy associated with the use of global budgets in two large public healthcare organizations, while considering both the characteristics of other control practice
Patients with dementia experience a steady deterioration in cognitive function that increases mortality and impairments. Moreover, dementia is also anticipated to increase significantly in prevalence as the world's population ages, placing a strain on healthcare systems throughout the globe. Hence, early identification and prediction of dementia are essential due to timely treatments, enhanced pat
Purpose: To define the curriculum content for two interactive learning courses on age-related macular degeneration (AMD): (1) an advanced course tailored for general ophthalmologists and (2) a basic course for non-ophthalmologist healthcare staff. This initiative aims to establish a national consensus on the educational framework for AMD management among general ophthalmologists in Denmark. Method
Few existing studies have delved into individual-level attitudes towards the exchange of sexual services for payment, leaving a significant gap in our understanding. Various studies have speculated about how certain demographic factors and attitudes may shape people's perceptions of causes and consequences relating to such exchanges, but none have directly investigated this topic. To bridge this g
Pituitary tumours, originating from endocrine cells of the anterior pituitary, are quite common, and in most cases well-controlled by surgery or medical treatment. However, a small subset of pituitary tumours presents with multiple local recurrences or tumour progression despite combined surgical, medical or radiotherapeutic treatment. These are known as aggressive pituitary tumours (APT); also ca
Cell replacement therapies using human pluripotent stem cell-derived ventral midbrain (VM) dopaminergic (DA) progenitors are currently in clinical trials for treatment of Parkinson’s disease (PD). Recapitulating developmental patterning cues, such as fibroblast growth factor 8 (FGF8), secreted at the midbrain-hindbrain boundary (MHB), is critical for the in vitro production of authentic VM DA prog
Artificial intelligence (AI) methods are powerful tools for biological image analysis and processing. High-quality annotated images are key to training and developing new algorithms, but access to such data is often hindered by the lack of standards for sharing datasets. We discuss the barriers to sharing annotated image datasets and suggest specific guidelines to improve the reuse of bioimages an
Background: The growing availability of electronic health records (EHRs) presents an opportunity to enhance patient care by uncovering hidden health risks and improving informed decisions through advanced deep learning methods. However, modeling EHR sequential data, that is, patient trajectories, is challenging due to the evolving relationships between diagnoses and treatments over time. Significa
Older adults are often portrayed as unwilling or unable to address quality issues in the formal care they receive. This study explores a methodology that captures the everyday reactions of older care users to quality problems, offering a nuanced understanding of their voice and agency when dissatisfied with care services. Using a telephone diary method, eight care users were contacted twice a week
A broad discussion of the ground-state potential-energy surfaces of doubly even deformed and transitional nuclei with Z = 50-82 is presented. The surfaces are calculated microscopically as functions of the quadrupole axial ε and non-axial γ and the axial hexadecapole ε4 deformations. A correlation between the form of the surfaces and the experimental spectroscopic trends is extensively discussed.
Purpose: Prolonged stress leading to sick leave is a serious health problem, and it is crucial to find ways to support recovery. The aim of this review was to synthesize the results from qualitative research about what people with stress-related disorders experience as supportive for recovery. Methods: The systematic review was designed as a qualitative meta-synthesis following the recommendations
Surface water pollution consists of various pollutants like heavy metals (Cu, Cr, Pb, and Ni), metalloids (Se, As, and Ag), and organic pollutants (dyes, antibiotics, pharmaceuticals, pesticides, and phenolic compounds). The escalating issue of water pollution requires innovative solutions for mitigation and climate resilience. Although various advanced techniques are being developed for removing
The intervention Balancing Everyday Life™ (BEL) helps service users achieve a balance among everyday activities and enhance personal recovery. BEL builds upon research for people with mental illness and on evidence from earlier activity-based interventions. This methodological paper presents the theoretical basis for BEL, which rests on five pillars of theories and models. Further, the BEL topics
Carbon Fibre-Reinforced Polymers (CFRP) are a fast growing market of high performance materials and components. Thermally induced damage during machining processes such as drilling or routing are among the limiting factors for product quality, yet accurate temperature measurement remains challenging. This study develops a methodology which combines machinable thermocouples and IR thermometry techn
