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Mammalian dihydroorotate dehydrogenase, the fourth enzyme of pyrimidine de novo synthesis is an integral protein of the inner mitochondrial membrane that faces the intermembrane space and is functionally connected to the respiratory chain via ubiquinone. Here, we describe the first cloning and analyzing of the complete cDNA of mouse dihydroorotate dehydrogenase. Based on our recent functional expr
Oscillatory neural activity in the cortico-basal ganglia-thalamocortical (CBGTC) loop is associated with the motor state of a subject, but also with the availability of modulatory neurotransmitters. For example, increased low-frequency oscillations in Parkinson’s disease (PD) are related to decreased levels of dopamine and have been proposed as biomarkers to adapt and optimize therapeutic interven
Background: The modern style of goalkeeping in ice hockey is thought to predispose athletes to hip and groin problems. However, little is known about the magnitude of these problems in elite goalkeepers.Purpose: To describe the incidence, prevalence, and severity of hip and groin problems in elite ice hockey goalkeepers over the course of a single season.Study Design: Descriptive epidemiology stud
Overheating in buildings is becoming a major concern and cause for various health issues. Existing research and previous studies on the issue were examined to acquire relevant information about the definition of overheating, its possible causes, and the heath impacts it could have on human health. The review included data on the current status of thermal comfort and overheating regulations in Swed
The effect of future changes in temperature and precipitation patterns on arctic ecosystem functioning is often assessed using state-of-the-art ecosystem models. Many models however lack detailed representation of wintertime processes, as pointed out by recent studies (Wang et al. 2016, Slater and Lawrence 2013). This bias may influence the derived outputs, such as soil temperature, permafrost ext
The demand for cheaper and more efficient solar cells is high. One way to decrease cost of material, while maintaining a high degree of efficiency, is to take advantage of nanomaterials. A thin film containing pn-junction nanowires can convert light with an efficiency comparable to traditional planar cells, while using a fraction of the material, and thus reduce costs. At the company Sol Voltaics
This is a master thesis where I investigate if there is an environmental awareness, willingness and commitment in the municipal housing companies to reduce the energy use in the building sector. Furthermore I investigate if the concept passive house or some other type of low - energy houses are used as measures. The government has imposed a state investment. The main purpose of the investment su
Background: The Finnish Shaft of the Humerus (FISH) trial compared open reduction and internal plate fixation (ORIF) with functional bracing in adult patients with displaced, closed humeral shaft fractures. Here, we compare the results of the patients in the randomized clinical trial (RCT [the randomized cohort]) with those of the cohort of patients who were also eligible but declined randomizatio
Breast cancer is the most common type of cancer in women worldwide. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of the oestrogen receptor, progesterone receptor, and amplification of HER2. This subtype is the most aggressive subtype and a heterogeneous subgroup of breast cancer, making up around 10-15% of the cases, often affecting younger patients
Notch wear often determines tool life when machining stainless steel. Chemical Vapour Deposited (CVD) Al2O3/Ti(C,N) coated cemented carbide tools are the first recommendation for turning of stainless steel. The CVD coating plays a vital role in reducing and delaying tool wear progress. Hence, it is essential to understand the interaction between the initiation of notch wear and the coating degrada
In stainless steel turning, cutting tool life is often limited by excessive localised damage at the depth of cut line, known as notch wear. Previous research revealed that notch wear in CVD (chemical vapour deposition) Al2O3/Ti(C,N) coated WC-Co tools begins as a coating brittle fracture already after 0.3 m of cutting. This paper investigates the impact of cutting tools and workpiece materials on
Patients with non-obstructive hypertrophic cardiomyopathy (HCM) exhibit myocardial changes which may cause flow inefficiencies not detectable on echocardiogram. We investigated whether left ventricular (LV) kinetic energy (KE) and hemodynamic forces (HDF) on 4D-flow cardiovascular magnetic resonance (CMR) can provide more sensitive measures of flow in non-obstructive HCM.Methods and resultsNinety
Tool wear intensity is one of the major performance and economic indicators of metal cutting processes. Understanding and control of tool wear and its governing mechanisms enables effective and sustainable manufacturing. Known wear mechanisms include abrasive, adhesive, chemical and diffusional, where their individual or combined action leads to an overall tool degradation. In this study, we prese
We report the discovery and characterization of two sub-Saturns from the Transiting Exoplanet Survey Satellite (TESS) using high- resolution spectroscopic observations from the MaHPS spectrograph at the Wendelstein Observatory and the SOPHIE spectrograph at the Haute-Provence Observatory. Combining photometry from TESS, KeplerCam, LCOGT, and MuSCAT2, along with the radial velocity measurements fro
BACKGROUND: Platelet transfusions are frequent in the Intensive Care Unit (ICU), either as prophylaxis against bleeding complications or as treatment for bleeding. The European Society of Intensive Care Medicine guidelines for ICU patients generally recommend not using prophylactic platelet transfusions unless the platelet count falls below 10 × 10 9 cells/L in non-bleeding patients and make no re
