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Background: In this study, we further developed an artificial intelligence (AI)-based method for the detection and quantification of tumours in the prostate, lymph nodes and bone in prostate-specific membrane antigen (PSMA)-targeting positron emission tomography with computed tomography (PET–CT) images. Methods: A total of 1064 [18F]PSMA-1007 PET–CT scans were used (approximately twice as many com
BACKGROUND: Balloon-guide catheters (BGC) have been associated with improved procedural and functional outcomes following endovascular thrombectomy (EVT) in multiple observational studies. Recently the PROTECT-MT trial challenged this benefit, showing worse functional outcomes when using BGCs. This study aims to assess the association between BGC-use and procedural and functional outcomes in a lar
This paper presents a novel convolutional neural network (CNN)-based control chart for detecting localized and subtle speckle shifts (displacements) in the images. To enhance detection accuracy, especially in detecting localized and simultaneous shifts, we design a custom CNN architecture and utilize a training methodology. Moreover, instead of inputting the entire images, we divide them into equa
Objective: To identify and quantify risk factors for incident knee osteoarthritis (KOA) across the lifespan. Methods: This systematic review and meta-analysis identified eligible studies from seven electronic databases and three registries. Longitudinal cohort studies or randomised controlled trials evaluating participants who developed incident symptomatic and/or radiographic KOA were included. T
Background and aims: Heart transplantation is the preferred treatment for selected patients with end stage heart failure. Kidney function often declines after heart transplantation. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) slow the decline in eGFR in different populations. However, the effect of SGLT2i on kidney function in heart transplant recipients is unknown. Methods: The Dapaglifloz
This article examines how the U.S. ‘inclusion-and-difference paradigm’translates to the Swedish context. According to Steven Epstein (2007), thisparadigm combines health equity arguments for racialised minorities andwomen with a biological understanding of racial and gender differences inmedicine. Drawing on interviews with experts, policymakers, and clini-cians involved in international clinical
Direct reprogramming of somatic cells into neurons offers a promising strategy for studying neurological disorders and developing cell-based therapies. This protocol describes the 3D direct reprogramming of human glial progenitor cells into dopaminergic neurons. It includes spheroid formation, lentiviral transduction, neuronal induction using doxycycline, and validation via gene expression and imm
This chapter delves into the evaluation of national innovation policies through a case study of the Brazilian National Innovation Policy (NIP). Assessing these policies poses several challenges, including the difficulty of defining and measuring policy outcomes, the scarcity of reliable data, and the intricacies of interactions among various stakeholders involved in the policy. Additionally, polit
As the global energy transition progresses, a range of drivers and barriers will continue to shape consumer attitudes and behavioural intentions towards emerging low-carbon technologies. The innovation-decision process for technologies composing the residential sector such as hydrogen-fuelled heating and cooking appliances is inherently governed by the complex interplay between perceptual, cogniti
Sorption-enhanced steam reforming (SorESR) is an advanced thermochemical process integrating in-situ CO2 capture via solid sorbents to significantly enhance hydrogen production and purity. By coupling CO2 adsorption with steam reforming, SorESR shifts the reaction equilibrium toward increased H₂ yield, surpassing the limitations of conventional steam reforming (SR). The efficacy of SorESR critical
This study presents an approach of inventory, morphometric analysis, and geoconservation assessment of the exceptional denudation landforms of the Markovi Kuli geosite in North Macedonia. By integrating Digital Elevation Models (DEM) and orthophoto imagery processed from the UAV-based aerial photos of the area using Agisoft Metashape software, a high-resolution 0.1 m 3D model is produced. The mode
BackgroundAntibiotics are handled in large amounts at hospitals at many different wards due to the wide range of bacterial infections that are treated. Unnecessary use and occupational exposure to antibiotics should be avoided due to the risk of bacterial resistance development and adverse health effects including skin and respiratory hypersensitivity reactions in persons handling these drugs.Obje
Following the upgrade of the LNLS injector system with the addition of a 500 MeV booster synchrotron, the storage ring in vacuum ferrite injection kicker magnets started to show overheating due the interaction with high frequency electromagnetic fields induced by the electron beam in large currents. In this paper, we describe the design of a new ceramic chamber for the kickers, which minimize this
Children's outdoor play and access to nature are important for their health and development of environmental agency but there is a global decline of green spaces available to them. The aim is to explore the possibilities of creating nature-based outdoor settings for play and learning which benefit children as well as the wildlife and wider ecosystems. A fieldwork on developing nature based play se
Echinolittorina malaccana, a marine gastropod living on rocky shores along the Indo-West Pacific coasts, shows consistent mate choice in which males prefer to mate with females slightly larger than themselves. Previous studies suggest that the strength of this preference is, to a certain extent, context dependent, being influenced by both demographic and individual (potentially genetic) factors. T
While the Convention on the Rights of the Child (UNCRC) does not address research, it instigated a recognition that decisions concerning children and youth must be based on knowledge of their experiences from their own perspective and consider their specific views and wishes, highlighting their right to be heard. Participatory research underscores this right, arguing the engagement of children and
Land cover governs the biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene temperature conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Prog
Energy management in urban areas is challenging due to diverse energy users, dynamics environmental conditions, and the added complexity and instability of extreme weather events. We incorporate adaptive reinforcement learning (ARL) into energy management (EM) and introduce a novel approach, called ARLEM. An online, value-based, model-free ARL engine is designed that updates its policy periodicall
