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Persistent organic pollutants (POPs) and heavy metals are well known environmental pollutants. Even though numerous studies have been carried out to assess human exposures to these compounds, there is still a lack of data on humans from developing countries, especially in underprivileged children. The objective of this study was to assess the exposure to POPs and heavy metals in children from Dhak
Type 2 diabetes (T2D) is a metabolic disease characterized by insufficient insulin secretion and insulin resistance. Disturbed beta-cell function is the final culprit that leads to the development of T2D. In addition, impaired incretin effect is likely a part of the pathogenesis of T2D. The aim of this thesis was to study the role of CART in beta-cells and incretin producing L- and K-cells.Endogen
UNLABELLED: Here we show that a common polymorphism causing a valine to methionine amino acid substitution at codon 418 (V418M) in the CLCN7 gene is associated with femoral neck BMD in women. Our study adds to accumulating evidence that shows that common allelic variants in monogenic bone disease genes often contribute to BMD regulation in normal subjects.INTRODUCTION: The CLCN7 gene is a strong c
Popular Abstract in Swedish Tillväxthormon (GH) insöndras stötvis från hypofysen. Insöndringen är som högst nattetid, och de högsta nivåerna ses under puberteten för att därefter avta succecivt med ökande ålder. En av de vanligaste orsakerna till brist på GH är godartade tumörer i hypofys och hypofysnära områden där även behandling med kirurgi och strålbehandling kan bidra till hypofysinsufficiensIn childhood onset growth hormone deficiency (GHD) a reduction in cardiac left ventricular mass (LVMi) and impairment of cardiac systolic function, as well as in glomerular filtration rate (GFR) has been shown. In study I, we showed that a low dose of GH treatment for 10 months resulted in increased LVMi and kidney size. No significant improvement in cardiac systolic function or GFR, except for a
The Bolivian Altiplano is situated between two mountain ranges, the western and eastern central Andes in South America. It has two major lakes, Lake Titicaca to the north, and Lake Poopó to the south, which both are important for the nature as well as for the living conditions on the Altiplano. The two lakes are the remnants of large paleolakes. They are joined by the Desaguadero River. Lake Poopó
In the United States of today, there is an increasing interest taken in the books on comparative religion written by the Swedish poet and scholar Viktor Rydberg (1828–95). Last year two of his major works, Researches in Teutonic mythology (Undersökningar i germanisk mythologi, I) and Magic of the Middle Ages (Medeltidens magi), appeared in English reprint. At the same time Rydberg’s Our father’s g
The theoretical part develops Michael Grossman’s dynamic demand-for-health model by (a) letting the depreciation rate depend upon the level of health, (b) allowing a continuous set of health states, (c) introducing uncertainty (by letting health be a stochastic variable), (d) introducing social and private insurance and (e) releasing the assumption of an isoperimetric budget constraint. Beside the
PURPOSE: Tamoxifen is one of many standard therapeutic options currently available for estrogen receptor-alpha-positive breast cancer patients. Emerging data have suggested that levels of estrogen receptor coregulatory proteins play a significant role in acquiring resistance to antiestrogen action. It has been suggested that high levels of estrogen receptor coactivators and its mislocalization may
The codification of canon law in the twelfth and thirteenth centuries occurred at the same time as important changes in pastoral practice. This article deals with changes in the practice of baptism that are tied to changes in canonical regulations.Canon law makes a fundamental distinction between solemn baptism and emergency baptism. While emergency baptisms could take place anywhere and at any ti
With today's improved measurement and data storing technologies it has become common to collect data in search for hypotheses instead of for testing hypotheses---to do exploratory data analysis. Finding patterns and structures in data is the main goal. This thesis deals with two kinds of structures that can convey relationships between different parts of data in a high-dimensional space: manifolds
This thesis employs a combination of quantitative and qualitative methods of linguistic analysis to investigate how business organizations use discourse as a strategic tool to build and repair stakeholders’ trust. In addition, the thesis makes a methodological contribution by developing a novel corpus annotation method that offers solutions to some of the most significant challenges involved in re
IMPORTANCE: Little is known about whether the duration of adjuvant imatinib influences the prognostic significance of KIT proto-oncogene receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor α (PDGFRA) mutations. OBJECTIVE: To investigate the effect of KIT and PDGFRA mutations on recurrence-free survival (RFS) in patients with gastrointestinal stromal tumors (GISTs) treated wi
Bullying is a social process where many students not directly involved as bullies or victims are often present as bystanders, who can respond with pro-bullying (assisting and joining the bully or supporting the bully by cheering and laughing), passive bystanding, or defending. Self-determination theory proposed that autonomous motivation reflects a person’s volition, values and interests, and pred
ABSTRACT: BACKGROUND: Individuals with autism spectrum disorders (ASDs) often display symptoms from other diagnostic categories. Studies of clinical and psychosocial outcome in adult patients with ASDs without concomitant intellectual disability are few. The objective of this paper is to describe the clinical psychiatric presentation and important outcome measures of a large group of normal-intell
BACKGROUND: Cyclin A1 is a cell cycle regulator that has been implicated in the progression of prostate cancer. Its role in invasion and metastasis of this disease has not been characterized. METHODS: Immunohistochemistry and cDNA microarray analyses were used to assess protein and mRNA expression of cyclin A1 and proteins with roles in metastasis, including vascular endothelial growth factor (VEG
Popular Abstract in Swedish Hantering av avlopp och avfall är en del av alla människors vardag. Vår hälsa och miljö påverkas av metoderna vi tillämpar för att ta hand om rester från hushåll och industrier. Genom teknikens utveckling används idag bakterier i vattenreningsverk där avloppsvatten renas från alla skadliga föremål och föreningar. Med hjälp av matematiska uttryck och analyser, i samspel Biofilms are compact, sessile microbial communities that attach to surfaces in aqueous environments. In wastewater treatment, they are especially important for removal of phosphorus and nitrogen, which, if released into a receiving water body, can cause severe eutrophication. Mathematical models of biofilms in wastewater are used to understand the underlying processes and to describe and analyze b
Luke 1:28-38 is read in Church of Sweden every year during “Feast of the Annunciation”. During the sermons focus often lies on Mary as a role model for the people. A role model because Mary chose to accept the mission from God to carry Jesus in her womb. The question the essay answers is; Did Mary have a choice, could she say no to the angel Gabriel when he told her she would get pregnant and carr
Kvävereningen på Svedala avloppsreningsverk har under perioder varit ansträngd och Svedala kommun frågade sig därför vad som kunde göras för att förbättra kvävereningen så att kvävereningskravet på 10 mg/l kväve klaras till 2030 då ytterligare 3000 personer förväntas vara anslutna. En utredning startades därför för att identifiera vad som begränsar kvävereningen samt lösningar för att förbättra kvThe nitrogen effluent at Svedala wastewater treatment plant has under periods been high, and the municipality of Svedala therefore wanted to know what could be done to improve the nitrogen removal, so that the nitrogen effluent limit of 10 mg/l could be managed until 2030, when another 3000 persons are expected to be connected to the wastewater treatment plant. An investigation was therefore start
This master thesis addresses the electrically powered assisted bicycle (EPAC) as a future low-carbon commuting option and its market. The purpose of the report is to evaluate whether the EPAC can be used to improve the climate performance of the transport sector and to assess the outlook for the Swedish EPAC market. The EPAC is compared to the bicycle, car, bus and train and assessed thereafter. T
Högsta domstolen har som sista instans ett stort ansvar för rättsbildningen i den svenska rättsordningen och spelar därför en viktig roll i densamma. Denna roll och betydelse har liksom rättsordningen varit föremål för ständiga förändringar. Från Högsta domstolens grundande fram till år 1971 ansågs domstolen främst som en garant för att underrätterna dömde rätt och rättvist. 1971 tilldelades domstThe Supreme Court is the highest legal body in Sweden, and has together with the legislator the main responsibility for the formation and development of the Swedish legal system. Its role and importance has been subject to constant changes over the years. The Supreme Court’s position of today was defined in 1971, when the legislator decided that there should be a refined court of record. This ch
