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Smoking affects several disease processes. Epidemiological studies have previously found a negative association between primary Sjögren's syndrome (pSS) and smoking. The aim of this study was to examine whether markers of disease activity and cytokine expression in pSS patients differ between ever and never smokers. Fifty-one consecutive pSS patients and 33 population controls were included in the
Background: A common complaint by people with tinnitus is that they experience that the tinnitus causes attention and concentration problems. Previous studies have examined how tinnitus influences cognitive performance on short and intensive cognitive tasks but without proper control of hearing status. Purpose: To examine the impact tinnitus and high-frequency hearing thresholds have on reading co
Binary stars form from the same parent molecular cloud and thus have the same chemical composition. Forming planets take building material (solids) away from the surrounding protoplanetary disc. Assuming that the disc's accretion on to the star is the main process that clears the disc, the atmosphere of the star will show abundance reductions caused by the material accreted by the forming planet(s
In the last decade, organoid technology has filled the gap generated by the poor accessibility and unique features of the human brain. Organoids present several advantages in comparison with two-dimensional culturing, since they recapitulate cytoarchitecture in space and functionality of the tissue. Therefore, they mimic the unique features of human brain better than animal models. Although signif
Fundamental to regulatory guidelines is to identify chemicals that are implicated with adverse human health effects and inform public health risk assessors about “acceptable ranges” of such environmental exposures (e.g., from consumer products and pesticides). The process is made more difficult when accounting for complex human exposures to multiple environmental chemicals. Herein we propose a new
Most microalgal species are geographically widespread, but little is known about how they are dispersed. One potential mechanism for long-distance dispersal is through birds, which may transport cells internally (endozoochory) and deposit them during, or in-between, their migratory stopovers. We hypothesize that dinoflagellates, in particular resting stages, can tolerate bird digestion; that bird
Food may induce inflammation and favor development of metabolic diseases, which have been associated with increased inflammation and potential risk of cognitive impairment. It is customary to know whether food or disease promote inflammation. Our hypothesis was that Okinawan-based Nordic (O-BN) diet leads to decreased circulating concentrations of inflammatory and neural biomarkers. The objectives
Living with a life-limiting cancer illness can entail a turmoil of feelings such as constant fear of loss, suffering and dying. Because patients live longer with life-limiting illness, there is a need for enhanced understanding of how people make sense of and cope with the complicated aspects that this life situation brings on. In this article, we explore how bloggers with advanced cancer use meta
Hydroxide ion conducting poly(terphenyl alkylene)s functionalized with piperidine-based quaternary ammonium cations were synthesized via superacid-catalyzed polyhydroxyalkylations. By employing different synthetic strategies, we have systematically varied the structures of the cation and the backbone polymer to study the effects on morphology, stability and hydroxide conductivity. Two monomers wer
Thirteen women with senile dementia of Alzheimer’s type (SDAT) according to NINCDS-ADRDA and 21 age-matched control women, aged 75-96 years, were investigated with clinical examination, dementia rating scales and single photon emission computed tomography (SPECT) using99mTc-hexamethylpropyleneamine oxime (HM-PAO) as a tracer of regional cortical blood flow. The aim was to study whether typical SPE
INTRODUCTION: Breast hypertrophy is a condition associated with physical, psychological, and psychosocial problems. The primary aims of this study were to determine the impact of breast hypertrophy and the effects of breast reduction, performed on the basis of well-described inclusion criteria, on general and breast-related health, using both general and diagnosis-specific validated questionnaires
Introduction: The purpose of this study was to investigate potential associations between body composition and current smoking in young healthy women from high-risk families. Cigarette smoke contains >7000 chemicals of which 69 are established carcinogens and smoke also acts as an aromatase inhibitor. Smoking is now recognized as a carcinogen for the breast and influences both risk and prognosis.
Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. Methods: This larges
Type 1 diabetes (T1D) results from the interaction of genetic and environmental factors. Previous studies indicate an association between detection of Enterovirus (EV) genome in blood and the clinical onset of T1D. Insulin resistance can also represent a risk factor for progression to clinically overt T1D. This study aimed at evaluating whether there is association between both EV infection and in
Strategies to determine the removal efficiency of micropollutants in wastewater treatment plants (WWTPs) are widely discussed. Especially the evaluation of the potential benefit of further advanced treatment steps such as an additional tertiary treatment based on ozonation or activated carbon have come into focus. Such evaluation strategies are often based on the removal behavior of known micropol
Objective: The aim of this study is to assess the impact of age at onset on the prognostic value of Alzheimer’s biomarkers in a large sample of patients with mild cognitive impairment (MCI). Methods: We measured Aβ42, t-tau, hippocampal volume on magnetic resonance imaging (MRI) and cortical metabolism on fluorodeoxyglucose–positron emission tomography (FDG-PET) in 188 MCI patients followed for at
Objective. To determine whether low-dose ciclosporin was a more effective corticosteroid-sparing agent than AZA in patients with SLE. Methods. Patients with SLE requiring a change or initiation of a corticosteroid-sparing agent and who were taking >/=15 mg of prednisolone/day were randomized to receive either ciclosporin or AZA during this 12-month open-label multi-centre trial. There were strict
Popular Abstract in Swedish ”Har en galopperande häst vid något tillfälle alla hovarna i luften samtidigt?” Den här till synes enkla frågan är inte helt enkel att svara på eftersom det inte går att avgöra med blotta ögat om så är fallet. För att avgöra om hovarna verkligen är i luften på samma gång behöver vi andra redskap med bättre tidsupplösning än våra ögon. Första gången någon lyckades göra eOne objective of attosecond science is to study electron dynamics in atoms and molecular systems on their natural time scale. This can be done using attosecond light pulses. Attosecond pulses are produced in a process called high-order harmonic generation, in which a short, intense laser pulse interacts with atoms or molecules in a highly nonlinear process, leading to the generation of high-order
PURPOSE: The purpose of this study was to observe sickness absence before and after the cancer diagnosis among cancer patients with five common forms of cancer. METHODS: Using cohort data, we observed sick leave in the pre- and post-diagnostic phase among patients with colon, rectal, breast, prostate, or lung cancer (n = 2,738). We also identified reference subjects without cancer (total n = 12,24
