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Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. Hash-1 is a component of the Notch signaling cascade, whic
This dissertation places Pearl in the context of works by the English fourteenth-century contemplative writers (‘mystics’), as well as of patristic and other theological treatises, focusing on the theme of comprehending and speaking about a transcendent divine dimension. The purpose is to show that Pearl and the works of Julian of Norwich, Margery Kempe, Walter Hilton, Richard Rolle and the author
A pair of isogenic, nontypeable Haemophilus influenzae strains, one expressing protein D and the other protein D-negative, was compared in their ability to cause damage in a human nasopharyngeal tissue culture model. Damage was assessed by measuring the ciliary beat frequency (CBF) of tissue specimens at 12 h intervals. Cultures inoculated with H. influenzae manifested a decrease in CBF beginning
The gamma-decay of excited states in the neutron deficient isotopes Tc-87 and Tc-88 has been observed for the first time. The fusion-evaporation reactions Ni-58(S-32, p2n)Tc-87 and Ni-58(S-32, pn)Tc-88 at 110 MeV, Ca-40(Cr-50, p2n)Tc-87 and Ca-40(Cr-50, pn)Tc-88 at 170 MeV and Ni-58(Ar-36, alpha-pn)Tc-88 at 145 MeV beam energy were used. Unambiguous identification of these nuclei which are populat
Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below the age of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorour
[1] Methane fluxes were measured at five sites representing oligotrophic peatlands along a European transect. Five study plots were subjected to elevated CO2 concentration (560 ppm), and five plots to NH4NO3 (3 or 5 g N yr(-1)). The CH4 emissions from the control plots correlated in most cases with the soil temperatures. The depth of the water table, the pH, and the DOC, N and SO4 concentrations w
BACKGROUND: The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive glomerulonephritis, with or without lung hemorrhage, whereas autoantibodies spe
In this study we compare two types of Large Eddy Simulation (LES) turbulent combustion models with experimental data for a low swirl stabilized turbulent lean premixed flame. Such flames are a great challenge to numerical simulations since they are unsteady and sensitive to boundary conditions, and details of the experimental set-up. The two classes of LES turbulent combustion models considered ar
Isolation of the male and female DNA is one of the most important steps in obtaining the DNA profile of the perpetrator in sexual assault cases. The sample is obtained by taking a vaginal swab containing both epithelial cells from the female and sperm cells from the male from the victim. The purity of the extracted male fraction decides whether or not a single-source DNA profile of the suspect wil
Popular Abstract in Swedish Att ha en allvarlig hjärtsjukdom är oftast förknippat med oro och rädsla. När det bestäms att patienten ska genomgå en planerad hjärtoperation, kan det vara avgörande för patientens och de närståendes välbefinnande hur de bemöts av all hälso- och sjukvårdspersonal, som de kommer i kontakt med under väntetiden samt vilket stöd de då upplever. Att korrekt och saklig inforPatients waiting for cardiac surgery often consider the period from the decision for surgery to the time for the operation as long, heavy and dreary. Therefore, it is important that patients are supplied with structured oral and written information regarding their disease and its treatment, so that they are able to understand and discuss the forthcoming operation, the risk of complications and the
Popular Abstract in Swedish Mineraler fås från både fast och flytande föda. De senaste årtiondena har bordsvattenkonsumtionen ökat, och vattnets kemiska innehåll har alltmer kommit i fokus. Studier visar dessutom att grönsakers mineralinnehåll har minskat, vilket ökar betydelsen av mineralintag från annat håll. Den här doktorsavhandlingen omfattar fyra olika studier. I den första studien undersökMineral elements in drinking water have been in focus for more than a decade, especially as the habit of drinking bottled water has increased, not the least among young people. Minerals in drinking water have become more important since minerals in food, especially in vegetables, have decreased substantially the last decades. This thesis includes four different studies. In the first study 20 munic
Popular Abstract in Swedish Förbättrad bedömning av njurskador hos barn med urinvägsinfektioner Urinvägsinfektioner är vanliga och förekommer hos 1 - 4 % av alla barn. Urinvägsinfektion kan ge upphov till njurinflammation och ibland kvarstående njurskada (ärr) efter läkning. Det finns risk för fortskridande njurskada om det finns kvarstående njurskada efter en urinvägsinfektion, om barnet får uppThe aim of the present thesis was to define and evaluate a strategy for identification of children who are at risk of developing progressive renal lesions after acute pyelonephritis. Tc-DMSA renal scintigraphy is widely accepted as the most sensitive method for detecting parenchymal lesions and diagnosing acute pyelonephritis. Qualitative and quantitative evaluation standards were elaborated to i
Popular Abstract in Swedish Avhandlingen består av fem filosofihistoriska texter med en sociologisk och idéhistorisk orientering. Alla texterna rör sig inom samma tidsram, 1860-1910. De fokuserar vidare på filosofin i de nordiska länderna, och närmare bestämt universitetsfilosofin. Tre av texterna behandlar ämnets utveckling vid universiteten i Lund och Köpenhamn. Avhandlingens centrala tema är deThe dissertation comprises of five studies in the history of philosophy with primarily a sociological and history of ideas orientation. All the studies fall within the same timeframe, 1860-1910. Furthermore, they all focus on philosophy in the Nordic countries, and university philosophy in particular. Three of the texts take up the development of the discipline at the universities in Lund and Cope
Popular Abstract in Swedish Trögers bas är en molekyl som syntetiserades första gången 1887. Molekylen är stel, C2-symmetrisk och böjd i ca 90° vinkel och den formar en kiral hydrofob ficka. I denna avhandling beskrivs syntesen av nya analoger av Trögers bas. Aniliner, substituerade med halider i 2- och 3-position, har för första gången kondenserats till analoger av Trögers bas. Dessutom har det vTröger’s base was synthesized for the first time in 1887. The molecule is rigid, C2-symmetric and has a 90° angle, forming a chiral hydrophobic pocket. In this thesis, the synthesis of new analogues of Tröger’s base is described. 2- and 3-halo-substituted anilines have for the first time been condensed to Tröger’s base analogues. It has also been shown that anilines without substituents in para-po
For Mary Wollstonecraft, the moral purpose of government is to act on the principle of equality and protect the weak against the fact of inequality. The political day-to-day is characterized by classes and groups with competing interests, some more powerful than others. Wollstonecraft was a republican thinker and so it is reasonable to expect in her writings a notion of political society as repres
Popular Abstract in Swedish Det är välkänt att patienter som har gjort ett suicidförsök löper en ökad risk att i framtiden ta sitt liv. I de flesta fall görs suicidförsök av individer som på något sätt är utsatta för stress. Stress kan orsakas av en psykisk eller fysisk sjukdom. Psykosociala faktorer, såsom en skilsmässa eller en annan ohållbar situation i hemmet eller på arbetet, kan också förorsA suicide attempt is the best known predictor of completed suicide. It has long been assumed that most suicide attempts are the results of stress. The aim of this thesis was to examine some stress related peptides and their relations to the hypothalamic pituitary adrenal (HPA) axis, diagnoses and temperament in a heterogeneous group of suicide attempters shortly after a suicide attempt and at foll
Feature quantization is a crucial component for efficient large scale image retrieval and object recognition. By quantizing local features into visual words, one hopes that features that match each other obtain the same word ID. Then, similarities between images can be measured with respect to the corresponding histograms of visual words. Given the appearance variations of local features, traditio
Urban Squares suggests a specific and fresh take on agorology – the study of urban squares. The approach is one of recording everyday life and focusing on different ways to describe and investigate the public life and space of urban squares. The book comprises four empirical case studies of squares focusing especially on the urban material culture and spatio-temporal changes of these squares. The
