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Abstract Purpose: To assess the use of periscope grafts to the superior mesenteric artery (SMA) in extending the distal sealing zone of thoracic stent-grafts. Case Reports: Three patients with ruptured Crawford type I thoracoabdominal aortic aneurysms (TAAA) and 1 patient with a symptomatic type B dissection underwent endovascular repair; the celiac trunk was intraoperatively occluded in all patie
PURPOSE:: To investigate concordance between objective and perceived neighborhood walkability, their associations with self-reported walking and objective physical activity, and sociodemographic characteristics of individuals in neighborhoods with objectively assessed high walkability who misperceive it as low. METHODS:: In 1,925 individuals aged 20-66 years, recruited from administrative areas in
PurposeTo elucidate the temporal relationship between detection of glaucomatous optic disc progression, as assessed by fundus photography, and visual field progression.DesignProspective, randomized, longitudinal trial.ParticipantsThree hundred six study eyes with manifest glaucoma with field loss and 192 fellow eyes without any field defect at the start of the trial, from a total of 249 subjects i
Background - Patient-reported assessments of freezing of gait (FOG) in Parkinson's disease (PD), such as the FOG questionnaire (FOGQ), are needed because FOG is difficult to assess objectively. However, the measurement properties of the FOGQ have been sparsely assessed. Aim - To assess the measurement properties of the Swedish FOGQ, and to explore relationships between FOGQ scores and other aspect
The world-famous 'Orsten' Konservat-Lagerstätte has yielded detailed information about Cambrian arthropods and their morphology. Internal organs or soft tissues have, however, rarely been reported, an obvious palaeobiological drawback. In this study, we employed synchrotron radiation X-ray tomographic microscopy (SRXTM) to study microscopic 'Orsten' arthropods from the Cambrian of Sweden: Skara mi
pH is an important factor determining bacterial community composition in soil and water. We have directly determined the community tolerance (trait variation) to pH in communities from 22 lakes and streams ranging in pH from 4 to 9 using a growth based method not relying on distinguishing between individual populations. pH in the water samples was altered to up to 16 pH values, covering in situ pH
Malarial infection is associated with complex immune and erythropoietic responses in the host. A quantitative understanding of these processes is essential to help inform malaria therapy and for the design of effective vaccines. In this study, we use a statistical model-fitting approach to investigate the immune and erythropoietic responses in Plasmodium chabaudi infections of mice. Three mouse ph
Abstract in Finnish Arvioinnin kohteena oli vuosien 2008–2011 ja 2012–2015 aikana toteutettu pitkäaikaisasunnottomuuden vähentämisohjelmakokonaisuus, Paavo I ja Paavo II. Arvioinnissa keskityttiin ohjelmakokonaisuuteen ja sen eri osa-alueisiin näkökulmana asunto ensin -mallin toteuttaminen suomalaisessa yhteiskunnassa. Arviointiraportissa on kuvattu Iso-Britannian, Ruotsin ja USA:n asunnottomuustyThe review covered the whole of the programme to reduce long-term homelessness implemented during 2008–2011 and 2012–2015, Paavo I and Paavo II. The review focused on the programme as a whole as well as its different aspects from the point of view of implementing the Housing First model in Finnish society. The review report described work on homelessness done in the United Kingdom, Sweden and the
L-DOPA, the most effective drug to treat motor symptoms of Parkinson's disease, causes abnormal involuntary movements, limiting its use in advanced stages of the disease. An increasing body of evidence points to the serotonin system as a key player in the appearance of L-DOPA-induced dyskinesia (LID). In fact, exogenously administered L-DOPA can be taken up by serotonin neurons, converted to dopam
Popular Abstract in Swedish Dagens konsumenter översköljes ständigt av en aldrig sinande ström av budskap om vad man ska och inte ska äta för att leva hälsosamt. Detta bombardemang har ökat under de senaste årtiondena då diverse aktörer, så som representanter från hälso- och sjukvårdssektorn och statliga myndigheter, ytterligare har poängterat kopplingarna mellan individers matkonsumtion och derasConsumers today are constantly showered with a vast array of different messages about what and how they should and should not eat in order to lead a healthy life. This bombardment has escalated over the last decades as various actors, such as representatives from the medical community and public policy makers, have increasingly stressed the connections between individuals’ food consumption habits
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING IMMUNFÖRSVARET OCH KOMPLEMENTSYSTEMET Till skydd mot infektioner har människan sitt immunförsvar. Här ingår till exempel vita blodkroppar och en mängd olika proteiner. En viktig grupp av proteiner kallas för komplementsystemet, vilket består av ca 30 proteiner som kan angripa bakterier och andra oönskade partiklar och delta i för-störThe ability of many pathogenic microorganisms to cause infection is dependent on their ability to evade attack by the complement system of the host. One mechanism by which microorganisms may avoid complement attack is to bind complement inhibitory molecules present in the host. This thesis describes studies of the complement inhibitor C4BP and of inter-actions between C4BP and the human pathogen
Popular Abstract in Swedish Är narkomaners personlighet relaterad till den drog som de valt att använda och föredrar? Detta undersöktes i en grupp om 128 tunga narkotikamissbrukare varav 37 var kvinnor och 91 män. De tre droger det gällde var heroin, som användes av 30 kvinnor och 52 män, amfetamin (7 kvinnor och 32 män) och hasch (7 män). Narkomanernas personlighet bestämdes med hjälp av två perc
The safety, feasibility, and hemodynamic effects of mild hypothermia (MH) induced by transnasal cooling were studied in transcatheter aortic valve replacement (TAVR). MH is a common therapy following cardiac arrest and seems to have favorable effects in myocardial infarction and on hemodynamic stability. In TAVR, hemodynamic instability is common during rapid pacing. Twenty subjects undergoing TAV
OBJECTIVES: To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. METHODS: A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiograph
Background: Adenocarcinomas of the rectum shed viable cells, which have the ability to implant. Intraoperative rectal washout decreases the amount and viability of these cells, but there is no conclusive evidence of the effect of rectal washout on local recurrence after rectal cancer surgery. Methods: Data were analysed from a population-based registry of patients who had anterior resection from 1
The number of cancer patients living with metastatic disease is growing. The increased survival has led to an increase in the number of cancer-induced complications, such as pathologic fractures due to bone metastases. Surgery is most commonly needed for mechanical complications, such as fractures and intractable pain. We determined survival, disease free interval and complications in surgically t
The objective of this prospective cohort study was to describe real-life use of lipid-lowering drugs and low-density lipoprotein cholesterol (LDL-C) target-attainment rates 1 year after acute myocardial infarction (AMI). LDL-C was recorded at hospital admission for AMI and at follow-up at 2 and 12 months after AMI in 17,236 patients in the Swedish heart registry, SWEDEHEART, from 2004 through 2009
The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a
Thymidine kinase 1 (TK1) provides a crucial precursor, thymidine monophosphate (dTMP), for nucleic acid synthesis, and the activity of TK1 increases up to 200-fold during the S-phase of cell division in humans. An important part of the regulatory check-points is the ATP and enzyme concentration-dependent transition of TK1 from a dimer with low catalytic efficiency to a tetramer with high catalytic
Injury to the peripheral nerves in the upper extremity results in changes in the nerve, and at multiple sites throughout the central nervous system (CNS). We studied the long-term effects of an injury to the median nerve in the forearm with a focus on changes in the CNS. Four patients with isolated injuries of the median nerve in their 20s were examined a mean of 14 years after the injury. Cortica
