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Objective: Primary care is the base in many health care systems, and to identify the most registered diagnoses in primary care is a way to identify the overall health care use and needs in society. We estimated the rates of the 30 most common diagnoses in primary health care and their male to female ratio. Research design and methods: This was a study including inhabitants 18 years and older out o
This thesis combines quantitative, qualitative, and experimental approaches to address different aspects of distal radius fractures (DRFs) in the elderly.Study I was a registry-based cohort study of 5,536 DRF patients, of whom 259 (5%) sustained a concomitant distal metaphyseal ulna fracture. These patients, with a mean age of 73 years (SD 15), had nearly twice the odds of reporting severe symptom
Importance: Emerging evidence suggests that cholesterol plays a role in breast cancer (BC) metabolism, raising the possibility that cholesterol-lowering medications, such as statins, may improve BC prognosis. Objective: To evaluate the association between postdiagnosis statin initiation and BC mortality using an emulated target trial approach. Design, Setting, and Participants: This observational
Hjärntumör inklusive glioblastom.Glioblastom är den vanligaste sortens hjärntumör bland vuxna och samtidigt den mest elakartade. Glioblastom drabbar cirka 550 personer årligen i Sverige. När tumören upptäcks är behandlingen först operation för exakt diagnos och med syfte att avlägsna så mycket som det går av tumören, utan att orsaka skada för patienten, annars görs en diagnostisk biopsi. StandardAbstractBackground: Glioblastoma is the most common malignant brain tumor. Operation with maximal resection, if feasible, otherwise biopsy followed by radiotherapy and chemotherapy with temozolomide is standard therapy. The prognosis remains poor, with median overall survival being 15 months despite therapy. Improved monitoring and treatment response assessment will be important when seeking to im
The immune microenvironment of non-small cell lung cancer (NSCLC) is heterogeneous, which impedes the prediction of response to immune checkpoint inhibitors. We have mapped the expression of 49 proteins to spatial immune niches in 33 NSCLC tumors and report key differences in phenotype and function associated with the spatial context of immune infiltration. Tumor-infiltrating leukocytes (TIL), ide
Background: Dexmedetomidine is a selective alpha-2 agonist with minimal impact on the haemodynamic profile. It is thought to be safer than morphine or stronger opioids, which are drugs currently used for analgesia and sedation in newborn infants. Dexmedetomidine is increasingly being used in children and infants despite not being licenced for analgesia in this group. Objectives: To determine the o
Decentralized Cloud Storage (DCS) is considered to be the future for sustainable data storage within Web 3.0, in which we will move from a single cloud service provider to creating an ecosystem where anybody could be a cloud storage provider. Currently, the cloud storage market is highly dominated by centralized players like Amazon S3, Google Cloud, Box, etc. Decentralized projects like Storj, Fil
Laser-induced thermal grating spectroscopy (LITGS) has been proved for accurate thermometry and measurement of energy transfer processes in molecules. While electronic transitions are often used for excitation in previous LITGS works, here we report laser-induced thermal gratings formed by direct excitation of CO2 with an infrared (IR) laser at wavelength near 2 μm, with which high signal-to-noise
Background: It is thought that patients with inborn errors of immunity (IEI) are more susceptible to severe coronavirus disease 2019 (COVID-19) than the general population, but a quantification of this potential risk is largely missing. Objective: We assessed the impact of COVID-19 on patients with IEI. Methods: A nationwide cohort study was performed to estimate the relative risk (RR) for hospita
Observed high spin states in 30Zn and 66Dy isotopes with two protons outside the closed shells at Z = 28 and Z = 64, respectively, are discussed and compared with cranked Nilsson-Strutinsky calculations. Bands terminating at higher and higher spin values are formed from successive proton excitations across these shells. These bands show very different features depending on the number of excited pa
COVID-19 has affected the daily activities of people worldwide. Recommendations introduced to reduce the spread of the virus led to increased use of Information and Communication Technologies (ICT) to meet everyday needs. Such rapid digitalization had not been seen previously and not been possible to study before. Hence, this study aimed to identify and describe self-reported changes in usage of a
Purpose: To understand the current practice in relation to the management of topical therapy for cutaneous chronic Graft versus Host Disease (ccGvHD) and access to extracorporeal photopheresis (ECP) within European allogeneic haematopoietic cell transplantation centres by a survey of nurses. Method: This was a multicentre cross-national study at eligible European Blood and Marrow Transplant centre
FN-stadgans våldsförbud sätter upp ett absolut förbud mot våldsanvändning stater emellan, och endast en situation av självförsvar eller med mandat från säkerhetsrådet kan en stat få rätt att göra undantag från förbudet. Detta till trots finns det många exempel på fall av våldshandlingar som går utanför förbudets ramar, så kallade humanitära interventioner, och man har i dessa situationer hänvisat The UN Charter sets up an absolute prohibition on the use of force between states, and only a situation of self-defense or a mandate from the Security Council can give the right to make exceptions to the ban. Despite this, there are many examples of cases of violence that goes beyond the prohibition framework, so-called humanitarian interventions, and to justify those operations references to inte
Begreppet barnets bästa är inte något nytt begrepp inom den svenska familjerätten. Det är ett begrepp som med tiden har mognat och blivit allt mer anpassat till barnets behov. I denna uppsats ges till en början en historisk återblick kring barnets bästa och en inblick i hur utvecklingen har sett ut i den svenska rätten. Den tar också fasta på den nuvarande lagstiftningen för barnets bästa och barnThe term the best interest of the child is not a new concept in the Swedish family law. It is a concept that has developed with time and become more and more adapted to the child's needs. In this paper is initially given a retrospective about the best interests of the child and an insight into how the development has been in the Swedish law. It also takes note of the current legislation for th
When a person becomes a patient in the Auckland City Hospital, the largest public hospital in New Zealand, they often bring one or more family members with them for mental and physical support. This thesis focuses on these support persons, who in this thesis are referred to as the patient caregivers and their perspectives on staying at Te Whare Awhina (TWA). TWA is an accommodation provider run un
I en serie omdebatterade rättsfall från 2011 justerade CJEU tillämpningsområdet för EU-rätten på områdena fri rörlighet för personer och unionsmedborgarskapet. ”Zambranoregeln” utgör ett snävt undantag från domstolens regel om rent interna situationer. Om en unionsmedborgare riskerar att de facto förlora denna ställning samt de rättigheter som är knutna till den, genom att tvingas lämna unionens tIn a series of fascinating cases decided in 2011, the CJEU modified its classical approach to the scope of application of EU law in the areas of free movement of persons and Union citizenship. The “Zambrano rule” is a narrow exception to the well-known rule of the “purely internal situation”. If a Union citizen runs the risk of de facto losing his status as Union citizen and the rights thereto att
Miljöbron is a non-profit organization; their main purpose is to merge companies and students into different environmental projects. The projects can be an assignment, practical vocational training or degree thesis. Miljöbron is expanding and the demand from students and companies is rapidly growing. Because of the expansion, a large amount of information needs to be stored and managed in a struct
As almost three out of four EU citizens live in urban areas and this number is expected to further grow, studies on urban ecosystems and their services are crucial to understand a city’s environmental structure and capabilities. The European Commission has published a relative report which suggests an urban ecosystem condition indicator framework, yet without suggesting respective thresholds tha
Vulnerability to climate change and the capacity to adapt to it are the result of intersecting power structures, system dynamics, and social identity markers otherwise known as intersectionality; and thus, differ greatly between contexts. However, despite the stark contextual differences between small and metropolitan cities, and lower and higher income countries, the policy and study of climate c
