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Background: Degraded extracellular matrix can stimulate the innate immune system via the Toll-Like Receptor-4 (TLR4). In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off its protein cores by the proteases (trypsin and elastase) and potentially activate TLR4 signalling. Methods: To investigate this signalling event, a low sulphated HS (500 mu g/ml) w
In international research there is a near consensus that the importance of cities is growing. As the policymakers of contemporary cities redirect their policy orientations away from the goal of redistribution towards achieving economic competitiveness, and as they introduce new structures of governance, they are becoming more and more committed to entrepreneurial city politics. However, both the i
FN-stadgans våldsförbud sätter upp ett absolut förbud mot våldsanvändning stater emellan, och endast en situation av självförsvar eller med mandat från säkerhetsrådet kan en stat få rätt att göra undantag från förbudet. Detta till trots finns det många exempel på fall av våldshandlingar som går utanför förbudets ramar, så kallade humanitära interventioner, och man har i dessa situationer hänvisat The UN Charter sets up an absolute prohibition on the use of force between states, and only a situation of self-defense or a mandate from the Security Council can give the right to make exceptions to the ban. Despite this, there are many examples of cases of violence that goes beyond the prohibition framework, so-called humanitarian interventions, and to justify those operations references to inte
Den könsdiskriminerande reklamen har diskuterats under många år och varit under utredning ett flertal gånger. Syftet med denna uppsats är att ta reda på om det behövs lagstiftning som förbjuder könsdiskriminerande reklam eller om en sådan lag skulle vara grundlagsstridig. Idag finns ingen lagstiftning som förbjuder könsdiskriminerande reklam i Sverige. MD kom i ett rättsfall från 1976 fram till aThe sexist advertising has been under discussion for many years and it has been the subject of several investigations. The purpose of this essay is to find out if legislation prohibiting sexist advertising is necessary or if that kind of law would be contrary to the fundamental laws. There is no legislation against sexist advertisement in Sweden today. In a case from 1976, MD concluded that MFL i
When a person becomes a patient in the Auckland City Hospital, the largest public hospital in New Zealand, they often bring one or more family members with them for mental and physical support. This thesis focuses on these support persons, who in this thesis are referred to as the patient caregivers and their perspectives on staying at Te Whare Awhina (TWA). TWA is an accommodation provider run un
I en serie omdebatterade rättsfall från 2011 justerade CJEU tillämpningsområdet för EU-rätten på områdena fri rörlighet för personer och unionsmedborgarskapet. ”Zambranoregeln” utgör ett snävt undantag från domstolens regel om rent interna situationer. Om en unionsmedborgare riskerar att de facto förlora denna ställning samt de rättigheter som är knutna till den, genom att tvingas lämna unionens tIn a series of fascinating cases decided in 2011, the CJEU modified its classical approach to the scope of application of EU law in the areas of free movement of persons and Union citizenship. The “Zambrano rule” is a narrow exception to the well-known rule of the “purely internal situation”. If a Union citizen runs the risk of de facto losing his status as Union citizen and the rights thereto att
Climate change is happening, right now. Its effects will become more pervasive in our daily lives, and it is part of our task as urban designers to explore how to adapt our cities and communities. One of the places which has been at the forefront of climate resilience from centuries until nowadays is the Netherlands, especially regarding water management, sea level rise and flooding. In fact, Ams
This project aims to envision the future of virtual collaboration in the year 2030. Global trends show that ever since the Covid-19 pandemic, hybrid work has become a standard in almost all job sectors, making virtual collaboration crucial for the success of hybrid teams. Although the option to work from home partially or completely has well documented outcomes of higher employee productivity and
Food consumption is one of the main areas of concern if we should become successful in creating a sustainable future. However, there are diverse views on what sustainability is, and consumers have varied knowledge and commitment to consuming sustainable food. The aim of this thesis is to investigate the impact of consumer understanding of food labels on sustainable purchase behaviour and to explor
Distinktionsprincipen är en av de mest fundamentala principerna i internationell humanitär rätt. Distinktionsprincipen grundades i St. Petersburgdeklarationen från 1868 och syftade till att minska det dödliga våldet mot civila i väpnade konflikter. Principen är nu kodifierad i artikel 48, 51(2) och 52(2) i det första tilläggsprotokollet till Genevekonventionen. Det är lättast att utläsa principen The principle of distinction is one of the cardinal principles of international humanitarian law. The principle of distinction originated in the St. Petersburg Declaration in 1868, aiming to limit the civilian casualties in warfare. The principle is now codified in article 48, 51(2), 52(2) of the 1977 Additional Protocol I to the Geneva Convention. The principle is most prominent in article 48. Th
Sammanfattning Titel De Förklädda Följarna - En studie om hur förändringsmotstånd utvecklas över tid Slutseminariedatum 2016-05-25 Ämne/kurs Magisteruppsats på Civilekonomprogrammet, Organisation, 30 hp Författare Amanda Larsson, Lovisa Larsson & Helena Uggla Handledare Nadja Sörgärde Nyckelord Förändringsmotstånd, motstånd, relation, tid, anställda Syfte Syftet med studien är att bidrAbstract Title Followers in Disguise - A study about how resistance to change evolves with time Seminar date 25th of June, 2016. Lund University, Sweden Course Master thesis in Business Administration, Organization & Change Management, 30 University Credit Points (30 ECTS) Authors Amanda Larsson, Lovisa Larsson & Helena Uggla Advisor Nadja Sörgärde Keywords Resistance to change, res
I denna uppsats har jag undersökt den litteräre arketypen jurodivyj eller ”dåre för Kristi skull” och hur denna har utvecklats i den ryska litteraturen. Jag har kommit fram till att karaktärstypen kan porträtteras väldigt annorlunda från hur verklighetens exempel på heliga dårar har framställts i de hagiografiska helgonberättelserna. De underliggande skälen till denna utveckling går att hitta hos In this thesis, I have examined the literary archetype of the yurodivy or “fool for Christ’s sake” and how it has developed within Russian literature. I find that the character may be portrayed significantly different from the real-life yurodivy depicted in the hagiographic tales. The roots for this development are mainly found in Fyodor Dostoevsky, who constructed what is called the “stylized hol
Despite being their closest evolutionary relatives, chimpanzees have a substantially different brain compared to humans: Homo sapiens display larger and more complex forebrains, although the protein-coding genes between the two species are basically unchanged. Therefore, differences in the transcriptome and in regulatory networks must be further investigated to better understand the dissimilaritie
The aim with this Master’s Thesis work was to conduct research about different available authenticators, as well as implementing a multi-factor authenticator into the currently used login-application. The research included biometric authentication technologies, and investigation of how to implement these to create a highly secure and customizable multi-factor authentication for My Axis-accounts fo
År 2019 skedde en revidering av 12 kap. JB, även kallad hyreslagen. Genom lagändringen infördes nya regler för att råda bot på ett antal problem på hyresbostadsmarknaden. Ett av de problem som lagändringen syftat till att åtgärda var oskäliga hyror på andrahandshyresmarknaden, och en ny referensram för vad som utgör en skälig andrahandshyra infördes. Bestämmelsen har formen av en takregel, och sta
Syftet med denna uppsats är att analysera de olika förändringarna i lagstiftningen kring våldtäktsbrottet sedan brottsbalken beslutades 1962. Analysen kommer att fokusera på fyra olika förändringar som har funnits vara mest omfattande när det gäller brottet och diskussionerna som har ägt rum under lagstiftningsprocessen för dessa ändringar. I samband med detta kommer fyra olika reaktioner en persThe purpose of this essay is to analyze the different changes in the legislation regarding the crime of rape since the criminal code was entered into force in 1965. The analysis will focus on four different changes that have been found the most extensive regarding the crime and the discussions that have taken place during the legislative process of these changes. In conjunction with this, four di
We have recently shown that the human Nuclear pore-associated protein (NPAP1)/C15orf2 gene encodes a nuclear pore-associated protein. This gene is one of several paternally expressed imprinted genes in the genomic region 15q11q13. Because the Prader–Willi syndrome is known to be caused by the loss of function of paternally expressed genes in 15q11q13, a phenotypic contribution of NPAP1 cannot be e
III-V solar cells in the nanowire geometry might hold significant synthesis-cost and device-design advantages as compared to thin films and have shown impressive performance improvements in recent years. To continue this development there is a need for characterization techniques giving quick and reliable feedback for growth development. Further, characterization techniques which can improve under
