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A kinetic model of the fermentative production of lactic acid from glucose by Lactococcus lactis ssp. lactis ATCC 19435 in whole-wheat flour has been developed. The model consists of terms for substrate and product inhibition as well as for the influence of pH and temperature. Experimental data from fermentation experiments under different physical conditions were used to fit and verify the model.

PURPOSE: The aim of the present study was to examine whether type 2 diabetic patients with good metabolic control achieved on diet treatment only, developed sight-threatening retinopathy during a four-year follow-up period. METHODS: A retrospective four-year follow-up study was carried out including all diabetic patients on diet treatment only, registered at the out-patient clinic at the Departmen

Type 2 diabetes (T2D) is a complex, metabolic disorder characterized by hyperglycaemia because of defects in insulin secretion and sensitivity. The rapid increase in T2D is likely to reflect the influence of both genetic and environmental factors in disease development. However, the genetic aetiology of T2D remains largely unknown. Thus, the aim of this thesis was to study the role of genetic vari

AIMS/HYPOTHESIS: The aim of this study was to ascertain whether treatment of GAD65 autoantibody (GADA)-positive diabetic patients with alum-formulated recombinant GAD65 (GAD-alum) is safe and does not compromise beta cell function. METHODS: This Phase 2, placebo-controlled, dose-escalation clinical trial, which was randomized through a central office, was performed in 47 GADA-positive type 2 diabe

BACKGROUND: Knowledge of the size and location of ischemic myocardium during acute coronary occlusion could provide decision support before reperfusion therapy. Electrocardiogram (ECG) scores based on the number of leads and the sum of ST-segment elevation have been unreliable in quantifying ischemia. We aimed to develop a new method to graphically display ischemic myocardium from simulated ECGs (

Objective: Chronic renal disease other than scleroderma renal crisis (SRC) is not well documented in systemic sclerosis (SSc). We examined the occurrence of decreased glomerular filtration rate (GFR) in a large consecutive SSc cohort and analysed whether it was related to SSc or could be related to other causes. Methods: During 1983-2004 GFR was measured by chromium-51-ethylenediaminetetraacetic a

Protein-based microarrays are among the novel class of rapidly emerging proteomic technologies that will allow us to efficiently perform global proteome analysis. However, the process of designing adequate protein microarrays is a major inherent problem. In this study, we have evaluated a protein microarray platform based on nonpurified affinity-tagged single-chain (sc) Fv antibody fragments to ge

The extant mammalian groups Monotremata, Marsupialia and Placentalia are, according to the ‘Theria’ hypothesis, traditionally classified into two subclasses. The subclass Prototheria includes the monotremes and subclass Theria marsupials and placental mammals. Based on some morphological and molecular data, an alternative proposition, the Marsupionta hypothesis, favours a sister group relationship

Cornelia de Lange syndrome (CdLS; OMIM 122470) is a rare multiple congenital anomaly/mental retardation syndrome characterized by distinctive dysmorphic facial features, severe growth and developmental delay and abnormalities of the upper limbs. About 50% of CdLS patients have been found to have heterozygous mutations in the NIPBL gene and a few cases were recently found to be caused by mutations

BACKGROUND: Job strain, defined as high job demands and low job control, has not previously been explored as a possible determinant of male fertility. We collected prospective data on job strain among men, and describe the associations with semen quality and probability of conceiving a clinical pregnancy during a menstrual cycle. METHODS: Danish couples (N = 399) who were trying to become pregnant

Cerebrospinal fluid (CSF) samples from 21 patients with a clinical diagnosis of Alzheimer's disease (AD) participating in a 5-year treatment study with the choline esterase inhibitor tacrin were retrospectively analyzed for the contents of beta-amyloid (Abeta42), total tau (T-tau) and phosphorylated tau (P-tau). A significant positive correlation between the level of P-tau and the number of sympto

Detection of genotype-specific human papillomavirus (HPV) capsid antibody in serum suggests past HPV infection. Also, these antibodies appear to correlate with vaccine-induced protection against infection, at least in animal models. However, each laboratory defines a reactive result differently and there is no agreed definition of what level of response indicates sero-reactivity. Standardization o

Introduction: Coagulation activation may be related to complications during surgery for abdominal aortic aneurysm. The complex formed between activated protein C (APC) and the serpin, protein C inhibitor (PCI), is a sensitive indicator of the activation of blood coagulation. The purpose of the study was to establish whether the APC-PCI complex can provide information useful for the assessment of o

Leaf-cutting ants combine large-scale herbivory with fungus farming to sustain advanced societies. Their stratified colonies are major evolutionary achievements and serious agricultural pests, but the crucial adaptations that allowed this mutualism to become the prime herbivorous component of neotropical ecosystems has remained elusive. Here we show how coevolutionary adaptation of a specific enzy

Det finns virtuell egendom i videospel med verkliga förmögenhetsvärden, varför den här undersökningen syftar till att utreda om denna företeelse är tjänlig som kreditsäkerhetsobjekt vid pantsättning i svensk rätt. För att uppfylla uppsatsens syfte används en rättsdogmatisk, och till viss del även en komparativ metod, tillsammans med både svenskt och utländskt material. Virtuell egendom är en företVirtual property in videogames with real monetary value is a reality. The purpose of this paper is to assess whether virtual property may be pledged in a credit transaction. This issue is addressed using both the Swedish legal dogmatic method (Sw. rättsdogmatisk metod), and partly a comparative method, in conjunction with Swedish and foreign material. The existence of virtual property is based on

Byggnationen av bostadshus med trästomme har enligt Statistiska centralbyrån ökat med 85% efter den senast lägsta uppmätningen 2011. Statistiska centralbyrån menar också att det är bostadshus bestående av 4-8 våningar som byggs mest i Sverige idag. Av denna statistik förutspås det bli en ökning av efterfrågan på bostadshus med 4-8 våningar med trästomme inom den närmsta framtiden. Tillsammans meThe construction of residential buildings with timber as load-bearing system has according to Statistics Sweden increased with 85% since 2011, which is the latest low point of the collected data. Statistics Sweden also shows how residential buildings consisting of 4-8 storeys are, in Sweden, the most built type of house today. Of these statistics, 4-8- storey residential buildings made with timber

Papineau's diagnosis of the "intuition of distinctness" IS THE MYSTERY AN ILLUSION? PAPINEAU ON THE PROBLEM OF CONSCIOUSNESS Pär Sundström Department of Philosophy and Linguistics, Umeå University Par.Sundstrom@philos.umu.se ABSTRACT: A number of philosophers have recently argued that (i) consciousness properties are identical with some set of physical or functional properties and that (ii) we can

https://www.fil.lu.se/hommageawlodek/site/papper/SundstromPar.pdf - 2026-07-10

I november 2021 beslutade den dåvarande regeringen att tillsätta en utredning för att göra en översyn av regleringen om frihetsberövande påföljder för unga. I augusti 2023 publicerades utredningen som ställer sig positiv införandet av s.k. ungdomsfängelser. Den frihetsberövande påföljd som i nuläget finns för unga lagöverträdare (15–17 år), utöver fängelse, är sluten ungdomsvård (och stadgas i 32 In November 2021, the Swedish government at the time decided to appoint an inquiry to review the regulations on custodial sanctions for young people. In August 2023, the investigation was published, which is in favor of juvenile prisons. The custodial sanction that currently exists for young offenders (15-17 years old), in addition to imprisonment, is "closed youth care" (and is stipulat