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Inorganic arsenic is a strong carcinogen, possibly by interaction with the telomere length. The aim of the study was to evaluate how chronic arsenic exposure from drinking water as well as the arsenic metabolism efficiency affect the individual telomere length and the expression of telomere-related genes. Two hundred two women with a wide range in exposure to arsenic via drinking water (3.5-200 mu
PURPOSE: We measured serum levels of human glandular kallikrein 2 (hK2) in patients with prostate cancer treated with radical retropubic prostatectomy for clinically localized prostate cancer to determine whether preoperative hK2 levels discriminate stage pT2a/b from pathological stage T3a or greater cancer. This finding would help to predict preoperatively the organ confined versus non-organ conf
Popular Abstract in Swedish Denna rapport behandlar trafiklaster på broar och de lasteffekter som de ger upphov till. Böjmoment och tvärkraft för olika brotyper beskrivs i form av statistiska fördelningar med tillhörande parametrar. Dessa är baserade på mätningar av verklig trafik gjorda i Sverige under åren 2002-2003 i Vägverkets regi. Resultaten finns redovisade i Vägverket (2004b), och finns laThis thesis treats traffic load effects in road bridges and in particular bending moment and shear force in different types of bridges. All traffic load effects are described in terms of statistical distribution functions for annual extreme values. The statistical distributions are based on measurements of real traffic, made in Sweden during 2002-2003. The measurements are managed by the Swedish R
To gain insight into the mechanisms responsible for the loss of the glucagon response to insulin-induced hypoglycemia in type 1 diabetes, glucagon responses to 4 different stimuli were examined over 3 months of diabetes in alloxan-treated mice. At 1, 6, and 12 weeks after alloxan (60 mg/kg), phloridzin (0.1 g/kg) was administered to overnight fasted diabetic mice to match the glucose levels of tho
Objective. The volume of colonoscopies performed is increasing and differences in colonoscopy practice over time and between centres have been reported. Examination of current practice is important for benchmarking quality. The objective of this study was to examine variations in colonoscopy practice in endoscopy centres internationally. Material and methods. This observational study prospectively
Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when dNTP levels are either unbalanced or elevated. RNR is the major player in this homeostasis, and with its four different substra
Background: The utility of conventional prostate-specifi c antigen (PSA) measurements in blood for monitoring rapid responses to treatment for prostate cancer is limited because of its slow elimination rate. Prior studies have shown that free PSA (fPSA), intact PSA (iPSA) and human kallikrein-related peptidase 2 (hK2) are eliminated more rapidly after radical prostatectomy. In contrast, all three
Forensic sexual assault samples typically contain a mixture of a small quantity of sperm cells and a high quantity of epithelial cells. This relationship complicates the generation of a DNA profile, which prompts the need for differential lysis and extraction of the DNA. Differential extraction is a lengthy method that includes multiple tube transfers and requires a purification step. Amicon Ultra
Denna studie är en fallstudie av en byggnad belägen i Malmö, Sverige, som undersöker olika energieffektiva åtgärder och deras potentiella påverkan på byggnadens energikonsumtion. En förstudie genomfördes för att inhämta kunskap om tillämpliga energieffektiva åtgärder från befintlig forskning. Därefter genomfördes fallstudien i tre huvudsakliga faser. I den första fasen samlades byggnadsinformationThis study is a single case study of a building situated in Malmö, Sweden, examining various retrofit measures and their potential impact on the building’s energy performance. A pre-study was carried out to gain knowledge on applicable retrofitting measures from existing literature. Subsequently, the case study consisted of three major phases. In the first phase, building information was collected
In the mountainous regions of Bhutan and Nepal, post-harvest losses cause significant challenges for producers. Open air sun drying is usually used by farmers to preserve their produce. There are many disadvantages to this method. The Swedish Research Council is supporting a project called Solar Food: Reducing Post-Harvest Losses Through Improved Solar Drying, which aims to create a low-cost solar
OBJECTIVE-Metformin produced weight loss and delayed or prevented diabetes in the Diabetes Prevention Program (DPP). We examined its long-term safety and tolerability along with weight loss, and change in waist circumference during the DPP and its long-term follow-up. RESEARCH DESIGN AND METHODS-The randomized double-blind clinical trial of metformin or placebo followed by a 7-8-year open-label ex
Popular Abstract in Swedish Vid genterapi för man in nya gener i en individs celler. Detta kan göras med hjälp av modifierade virus. Dessa virus kan föra in den nya genen, den såkallade transgenen, in i värdcellen men inte bilda nya viruspartiklar. I många fall är det viktigt att begränsa i vilka celler som transgenen uttrycks, då det producerade proteinet kan ge bieffekter i andra celltyper. Det Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. The specificity of the vector is however important to avoid potential off-target effects
The relationship between capital structure and firm performance has been a recurring topic of discussion. Within this context, frameworks such as the Modigliani and Miller, Trade-Off, Market Timing, Pecking Order, Agency theories have been widely examined by researchers, offering diverse viewpoints on how capital structure decisions impact corporate performance in distinct industrial, regional and
To meet the growing demand of meat alternatives, this project was dedicated to creating a chicken analogue prototype with mycoprotein. Within the project, two approaches of alginate gelation, external (diffusion) crosslinking and internal crosslinking, were studied in this particular food matrix. Using the external crosslinking method, the effects of major ingredients on the texture, structure and
Nollbeskattningen av gemenskapsinterna förvärv i kombination med uppskjuten betalning av moms har möjliggjort karusellbedrägeri med moms på den EU-interna marknaden. Följaktligen har medlemsstaterna drabbas av utebliven moms som inte redovisas av ”missing traders”, samtidigt som den oskyldige affärspartnern till en ”missing trader” behåller sin rätt att återfå moms, vilket skapar en förlust för stThe zero-rating of intra-Community acquisitions in combination with the deferred payment of VAT has made it possible to employ carousel fraud with VAT on the internal EU market. Not only are the tax authorities in the different Member States losing out on VAT that is not accounted for by missing traders, but the innocent parties in business with the missing traders retain a right to refund VAT, le
DGEM (Devlabs, Copenhagen) is a small IoT product for air quality management and can be equipped with various integrated low-cost small sensors and hardware interfaces and provides comprehensive data collection capabilities. A one-month field observation test was conducted with reference instruments at Hyltemossa research station from 6th Dec. 2023 to 10th Jan. 2024 to validate this sensor bef
