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Research SummaryGrowth often requires start‐ups to recruit new skills not present in the founding team. We analyze if the relationship between integrating new skills and growth depends on timing. Should new skills be recruited as early as possible, or can start‐ups add them as needed along the way? Using a unique panel dataset covering Sweden's population of start‐ups from 1997 to 2012, our analys
Background: The occurrence of mosaicism in hemophilia A (HA) has been investigated in several studies using different detection methods.Objectives: To characterize and compare the ability of AmpliSeq/Ion Torrent sequencing and droplet digital polymerase chain reaction (ddPCR) for mosaic detection in HA.Methods: Ion Torrent sequencing and ddPCR were used to analyze 20 healthy males and 16 mothers o
Prisons are institutions through which states exert social control and deprive citizens of rights; where entitlements of citizens are limited to the bare minimum deemed acceptable to a given state. Therefore, prisons are institutions which reveal core aspects of the relation between a state and its citizens. In authoritarian regimes, as Myanmar was in a very recent past, prisons are places in whic
Fruit-feeding pteropodid bats roost under varying light conditions. Some roost in trees with high exposure to daylight (> 1000 lx), while others roost in dark caves (< 0.1 lx). To understand the effect of ambient light intensity and moon phase on flight activity, we examined flight times across five lunar cycles in three pteropodid species whose roosts differ in daylight exposure. We found signifi
The smaller isoform of glutamic acid decarboxylase, GAD65, is an important autoantigen implicated in the pathogenesis of type 1 diabetes whereas the larger isoform, GAD67 appears to play no major role. The primary difference between the two isoforms resides in the N-terminal part of the molecule including the GAD65 membrane-anchoring domain. The aim of this study was to generate mutants of the mem
Efficient handling of faults during operation is highly dependent on the interval (latency) from the time embedded monitoring instruments detect faults to the time when the fault manager localizes the faults. In this article, we propose a self-reconfiguring IEEE 1687 network in which all instruments that have detected faults are automatically included in the scan path, and a fault detection and lo
During asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract for extended periods of time without causing symptoms of urinary tract infection. Previous studies indicate that many Escherichia coli (E. coli) strains that cause ABU have evolved from uropathogenic E. coli (UPEC) by reductive evolution and loss of the ability to express functional virulence factors. For instance, the prot
Popular Abstract in Swedish Antonymer är motsatsord, t.ex. stor-liten, kort-lång, och varm-kall. Den här avhandlingen handlar om antonymer och om vilken typ av lexikal information som man kan lagra i ett elektroniskt lexikon (Svenskt Ordnät) samt hur man kan få fram lexikal information ur stora textmassor med datorns hjälp. Baserat på hur vanliga ord är kan man beräkna hur ofta man kan förvänta siHow are antonym relations acquired? What types of lexical information can be extracted from corpora and how? How can this information be encoded in a lexicon? The work in this book was developed within the framework of WordNet. A further elaborated lexical model is suggested, as well as methods for implementing it. The first part of the book is a study of adjectives co-occurring with adjectives. E
Objective: Emergency department (ED) staff need to rapidly establish accurate diagnosis and management for children with arrhythmias. Limited data are available on the presenting features, epidemiology and management of arrhythmias encountered in the ED. The aim of this study was to characterise the incidence, presenting features, management and outcomes of arrhythmias at a large tertiary children
This paper examines how, if artificial agents are capable of wellbeing, their wellbeing should be compared and aggregated alongside human wellbeing. Building on arguments from Goldstein and Kirk-Giannini, who suggest that some AI systems may possess wellbeing, I explore the moral implications of this possibility. Rather than reinventing debates in population ethics, this paper adapts and extends t
Background There is limited knowledge on whether prior knee surgery impacts the clinical profile and treatment outcomes for individuals with knee osteoarthritis (OA). Objectives The study aimed to (i) compare individual and clinical characteristics, and (ii) evaluate whether outcomes of first-line treatment differ between individuals with prior knee surgery and those without. Methods This study us
Until now, computationally designed enzymes exhibited low catalytic rates1, 2, 3, 4–5 and required intensive experimental optimization to reach activity levels observed in comparable natural enzymes5, 6, 7, 8–9. These results exposed limitations in design methodology and suggested critical gaps in our understanding of the fundamentals of biocatalysis10,11. We present a fully computational workflow
Telomeres are the conservative sequence repeats located at the end of linear chromosomes that have been the focus of intensive research across many disciplines over the last four decades. They function as a cap to protect the chromosome ends from fusion to other chromosomes and to prevent chromosome degradation. Telomere shortening is thought to be involved in ageing, reflecting or even causing ag
Numerical simulations using large eddy simulation (LES) and Unsteady Reynolds Averaged Navier–Stokes (URANS) are carried out to identify the underlying mechanisms that govern the early soot evolution process in an n-dodecane spray flame at 21% O2 by molar concentration. A two-equation phenomenological soot model is used here to simulate soot formation and oxidation. Both ignition delay time (IDT)
BACKGROUND AND OBJECTIVES: Cytoreduction with hyperthermic intra-peritoneal chemotherapy (HIPEC) is a treatment with a high morbidity. Optimal patients selection can possible reduce toxicity and complications.PATIENTS AND METHODS: Complications and toxicity of 102 patients were studied. Toxicity was graded according National Cancer Institute Common Toxicity Criteria (NCI CTC) classification. A com
We address the social sustainability dimension of labor-intensive industrialization (LII) and manufacturing activities and apply it to the analysis of Mauritius, a regional forerunner in textile and garment production. While the country is commonly seen as an African success story, we do not evaluate its trajectory against traditional economic theory on achieving sustained growth. Instead, we anal
An additional upsurge in bacterial STIs has been observed in Sweden following HIV pre-exposure prophylaxis (PrEP) implementation. From a prevention perspective, it is of relevance to optimize testing strategies within PrEP programmes to identify those most at risk. An open retrospective longitudinal observational cohort study was performed at three STI clinics in Uppsala, Gothenburg, and Malmö. A
Background: Acute kidney injury (AKI) is a serious complication after lung transplantation, but the reported incidence varies in the literature. No data on AKI have been published from the Swedish lung transplantation program. Methods: The aim of our study was to investigate the incidence, perioperative risk factors, and effects of early postoperative acute kidney injury (Kidney Disease Improving
High-speed vertical III–V nanowire transistors utilize their channel material for high frequency and low noise performance. A device layout revision to optimize gate resistance, in a trade-off to gate-source capacitance, is presented. A two-step redesign of the established device layout is proposed. First step is demonstrated with fabricated structures. The second step predicts the design transiti
Few-shot segmentation (FSS) tackles data scarcity using multiple priors, but its simplicity limits handling base and novel classes with limited data access. Generalized few-shot semantic segmentation (GFSS) enhances model performance for base classes with abundant data, while novel classes have limited data access, improving generalization with scarce data. Building on the design of query-based se
