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Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.
Riktlinjer för utformning av Sida 1 av 1 FÖRSÄTTSSIDA STYRDOKUMENT Riktlinjer för utformning av examensbevis från utbildning på grundnivå och avancerad nivå vid Lunds universitet Typ av styrdokument: Riktlinjer Definition av typen av styrdokument: Riktlinjer fastställer hur någon ska eller bör handla inom det område riktlinjerna omfattar. En ska- regel ska följas medan en bör-regel mer har karaktä
https://www.isk.lu.se/euprera2025 - 2026-07-13
Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl
A search for direct pair production of top squarks in final states with two tau leptons, b-jets, and missing transverse momentum is presented. The analysis is based on proton-proton collision data at s=13 TeV corresponding to an integrated luminosity of 36.1 fb-1 recorded with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. Two exclusive channels with either two hadronically deca
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou
Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac
Introduction: Genetic technologies advance rapidly. It is possible to undergo genetic carrier screening before pregnancy to examine genetic risks to future offspring. We aimed to investigate parents’ interest and motives towards preconception genetic carrier screening (PCS) as well as factors associated with interest in PCS. Material and methods: Our study sample consists of 777 parent couples wit
Kursansvarig Roger Hildingsson roger [dot] hildingsson [at] svet [dot] lu [dot] se (roger[dot]hildingsson[at]svet[dot]lu[dot]se) Litteraturlista: (PDF, 225 kB, ny flik) Kursböcker OBS! Vissa artiklar kan ändras/tillkomma under kursens gång! Kursböcker Boyce, T. and Lewis, J., eds. (2009). Climate Change and the Media. Global Crises and the Media Series. Peter Lang Pub Inc. (Svårtillgänglig, utva
https://www.cec.lu.se/sv/litteraturlista-klimatpolitik-samhallsstyrning-och-kommunikation-2022 - 2026-07-13
In everyday conversations, we frequently give an example. Yet this is seldom accompanied by any reflection on what is going on when we do so. This report tries to contribute such a reflection. It shows how examples may be marked and used in a particular discourse: oral discourse on others. The empirical material is a transcribed focus group interview with a group of Swedish students, engaged in di
Protein S deficiency is an autosomal dominant disorder that results from mutations in the PROS I gene. Conventional mutation detection techniques fail to detect a pathogenic PROSI mutation in approximately 50% of cases. The present study investigates whether large deletions of PROS I are found in families where mutations in the PROS I gene have not been found despite sequencing. For this purpose,
