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Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post-translational methylation, but several of the responsible enzymes remain unknown. Using a wide range of experimental approaches, we here show that human methyltransferase (MTase)-like protein 13 (METTL13) contains two disti
Lokalt samarbetsavtal för AkademikerAlliansen i XX kommun Detta samarbetsavtal avser lokal samverkan mellan de förbund inom AkademikerAlliansen som väljer teckna detta avtal. 1.0 Ändamål 1.1 Avtalets syfte är att reglera förutsättningarna som ska gälla mellan de förbund som ingår i föreningen. 2.0 Bildande av den lokala föreningen 2.1 Utgångspunkten för att bilda lokal förening är att det är frivi
Lönesamtal | Akademikerföreningen vid Siemens Energy AB Hoppa till huvudinnehåll Öppna sökruta Öppna Huvudmeny Sök på saco.se Om oss Stadgar Kollektivavtal Bli medlem Nyheter Nyhetsbrev Kaffekampanj Presentation "Will I be poor when I retire" Löneskola 2026 Lecture "Swedish pension system", 15th of April 11:45 Lecture "Working in Sweden" 16th of December Presentationsmaterialet från pensionsförelä
The glymphatic system facilitates cerebrospinal fluid (CSF)-interstitial fluid exchange and plays a key role in solute clearance and neurophysiological homeostasis. While dysfunction of this system has been shown in traumatic brain injury, stroke, meningitis, idiopathic normal pressure hydrocephalus and neurodegenerative diseases, direct measurement of glymphatic transport in humans remains elusiv
KALLELSE Ledamöterna i Saco-S-rådet vid Göteborgs universitet kallas till ordinarie årsmöte Torsdagen den 22 maj 2014 kl 16.00 Plats: CE04 på Pedagogen, Hus C, Läroverksgatan 5 Kallelsen är utsänd till Dig efter information från Ditt förbund. VÄLKOMNA! Föredragningslista 1. Sammanträdet öppnas 2. Fastställande av röstlängd (bilaga 2) 3. Fråga om adjungering 4. Val av mötesordförande 5. Val av möte
Cannabinoid receptors 1 (CB1) and/or 2 (CB2) are overexpressed in many types of human malignancies including mantle cell lymphoma (MCL). Agonists to CB1 and CB2 promote ceramide de novo synthesis, p38-mitogen-activated protein kinase-dependent activation of caspase-3 and apoptotic cell death in most MCLs. However, in this report we describe that in some MCLs the response to treatment with cannabin
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs). However, COX-2 is also constitutively expressed, in the absence of overt inflammation, with a specific tissue distribution that includes the kidney, gastrointestinal tract, brain, and thymus. Constitutive COX-2 expression is therapeuti
Voles of the genus Microtus represent one of the most speciose mammalian genera in the Holarctic. We established a molecular phylogeny for Microtus to resolve contentious issues of systematic relationships and evolutionary history in this genus. A total of 81 specimens representing ten Microtus species endemic to Europe as well as eight Eurasian, six Asian and one Holarctic species were sequenced
Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultra
Popular Abstract in Swedish Arbetare i gummiindustrin utsätts för ett stort antal kemikalier med hög giftighet. Tidigare forskning har visat att kemikalierna innebär en fara för hälsan. Gummiarbetarna har tidigare haft en ökad risk att drabbas av olika sjukdomar, t.ex. cancer, hjärtkärlsjukdomar och luftvägsbesvär, jämfört med allmänbefolkningen. Däremot vet man inte exakt vilka ämnen som är farliWorkers in the rubber industry have an increased risk of several diseases, such as airway disease, cancer and probably cardiovascular disease. The exposure is very complex; carbon disulfide (CS2) and polycyclic aromatic hydrocarbons (PAHs) being two of the contaminants. The general aim of this thesis was to find exposure-response relationships usable for risk assessments in the rubber industry. U
Popular Abstract in Swedish Cancer är på cellnivå en genetisk sjukdom, i det avseendet att typiska egenskaper för cancerceller, t ex okontrollerad celldelning samt abnorm känslighet för yttre regulatoriska signaler, uppkommer genom förvärvade och ibland ärftliga förändringar, s k mutationer, i cellens arvsmassa. Hur mutationerna uppstår är bara till viss del känt. Somliga förändringar beror på strAcquired genetic alterations, of which many are visible on the chromosome level, are believed to be necessary for tumorigenesis, and most tumors display characteristic patterns of recurrent structural and numerical aberrations. However, two of the most frequently occurring chromosome mutations in malignant and benign solid tumors, i.e., trisomy 7 and rearrangements of 12q13-15, have recently been
Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as
Popular Abstract in Swedish Prosodi definieras som talets rytmiska, dynamiska och melodiska egenskaper (Bruce, 1998). Till de prosodiska dragen hör längd (kvantitet), betoning (tryck- och ordaccent), ton, satsmelodi (intonation) och gränser (tomrum i talvågen). Dessa drag används i kommunikativt syfte för att särskilja betydelser hos ord och orddelar, för att framhäva och gruppera delar av talet oThe aim of this thesis was to explore prosodic problems in Swedish children with language impairment (LI). In the first study, 29 children with LI participated. They were assessed with an assessment procedure for prosody at the word, phrase and discourse levels, developed within this thesis. The results showed that 41% of the children had prosodic problems to some extent. In addition, reliability
The surface properties of several modified stainless steel samples were characterized according to their chemical composition, roughness, topography and wettability. The modifications tested were SiF3+ and MoS22+ ion implantation; diamond-like carbon (DLC) sputtering: DLC. DLC-Si-O and SiOx, plasma enhanced chemical vapor deposition (PECVD); autocatalytic Ni-P-PTFE and silica coating. X-ray photoe
Dysfunctional insulin secretion is a hallmark of type 2 diabetes (T2D). Interestingly, several islet microRNAs (miRNAs) are upregulated in T2D, including miR-132. We aimed to investigate whether in vivo treatment with antagomir-132 lowers expression of miR-132 in islets thereby improving insulin secretion and lowering blood glucose. Mice injected with antagomir-132 for 24 h, had reduced expression
An automated on-line sampling method was developed using microdialysis as the simultaneous sampling and sample pre-treatment technique. The extraction fraction values of microdialysis probes sampling different eicosanoids were investigated. The impact of cyclodextrins in the perfusion liquid used for sampling hydrophobic eicosanoids in biological systems was also studied. The total time for one an
Impaired beta-cell function is key to the development of type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties. Here we studied the role of endogenous CART in beta-cell function. CART silencing in INS-1 (832/13) beta-cells reduced insulin secretion and production, ATP levels and beta-cell exocytosis. This was su
PURPOSE: The purpose of this study was to identify genetic aberrations contributing to clinical aggressiveness of malignant peripheral nerve sheath tumors (MPNSTs). PATIENTS AND METHODS: Samples from 48 MPNSTs and 10 neurofibromas were collected from 51 patients with (n = 31) or without (n = 20) neurofibromatosis type 1 (NF1). Genome-wide DNA copy number changes were assessed by chromosomal and ar
Background and purpose: beta(2)-Adrenoceptor agonists (beta(2)-agonists) are important bronchodilators used in the treatment of asthma and chronic obstructive pulmonary disease. At the molecular level, beta(2)-adrenergic agonist stimulation induces desensitization of the beta(2)-adrenoceptor. In this study, we have examined the relationships between initial effect and subsequent reduction of respo
