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Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) c
Abstract Through the use of chimeric CXCR4/CCR5 receptors we have previously shown that CCR5-tropic (R5) HIV-1 isolates acquire a more flexible receptor use over time, and that this links to a reduced viral susceptibility to inhibition by the CCR5 ligand RANTES. These findings may have relevance with regards to the efficacy of antiretroviral compounds that target CCR5/virus interactions. Compartme
Pareto optimality is a concept that formalises the trade-off between a given set of mutually contradicting objectives. A solution is said to be Pareto optimal when it is not possible to improve one objective without deteriorating at least one of the other. A set of Pareto optimal solutions constitute the Pareto front. The Pareto concept applies well to the inverse planning process, which involves
Introduction: Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)-derived LZC and MSE differences between responder
Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat
Forskningsnämnden (FN) har det övergripande strategiska ansvaret för att främja och utveckla forskningen vid LTH med hänsyn till strategiska mål satta av LTH:s styrelse. Ordinarie ledamöterMargaret McNamee, prorektor, professor, ordförandePer Augustsson, universitetslektor, vice ordförandeAnna Fureby, professorAndrew Karvonen, professorStephen Hall, universitetslektorJohan Eker, professorKimberly
https://www.lthin.lth.se/organisation/fakultetsorgan/ledningsgrupper-namnder-och-kommitteer/namnder/forskningsnamnd - 2026-07-07
Nationalekonomiska institutionen Introduktionsmöten som hålls i Nationalekonomiska institutionens regi är inte obligatoriska. Om du väljer att inte närvara på dessa möten förväntas du på egen hand inhämta den information som meddelas.Du skall själv registrera dig på dina kurser via studentportalen www.student.lu.se senast sista registreringsdag. Om du inte gör detta förlorar du din plats. Om du är
In this article we elaborate on the process of institutionalization in the Higher Education performance evaluation ecosystem. We argue, we can observe a shift in how research evaluation functions, namely, from the contribution to knowledge to that of the societal influence of research. Such an axiological shift in evaluation goes to the very core of academic scholarship, as the commoditised neolib
The Goal/Question/Metric paradigm is used for empirical studies on software projects. Support is given on how to define and execute a study. However, the support for running several subsequent studies is poor. V-GQM introduces a life-cycle perspective, creating a process, spanning several GQM studies. After the GQM study has been completed, an analysis step of the plan is initiated. The metrics ar
On the basis of the Agent-action-Objective (AaO) paradigm, it will be shown how the transformation of a word model to a geometric space description can be made the founda¬tion for an approach to informational invariants. In particular, the word model of a Causal Loop Diagram (CLD) has been used for simplifying the involved procedures. Since the explanation of a causal loop requires a verbal descri
When exploring possible energy saving measures for existing buildings different technical solutions should be investigated. In Malmö, Sweden, a 1930s hospital in a park setting has been refurbished with a general sustainability goal. For one of the buildings a glass-façade has been added to an existing 80-year old brick building. Measurements of relevant temperatures have been made including meas
The aim of this study is to examine how Swedish regions and cities are making use of Europe by various forms of lobbying efforts, and describe what role they are playing in EU’s multi-level system. The study initially concentrates on the development of the regional offices in general, and the Swedish offices in particular. Additionally, the study intends to discuss the possibilities and impli
In developing countries across the world people are depending on rivers as a source of water for drinking, cooking and bathing. This is also the case in the Indonesian part of the island Borneo where this study was made. The largest river is the river Kapuas which, together with its tributaries, supplies the area with water. The hydrology of these rivers is changing and the quality of the water in
Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years since the discovery of AIDS, there is still no cure or vaccine against HIV. Consequently, the concepts of functional vaccines and cures that aim to limit HIV disease progression and spread by persistent control of viral
Using dislocation simulation approach, the basic equation for a finite crack perpendicular to and terminating at a bimaterial interface is formulated. A novel expansion method is proposed for solving the problem. The complete solution to the problem, including the explicit formulae for the T stresses ahead of the crack tip and the stress intensity factors are presented. The stress held characteris
