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BACKGROUND: The aims of this study were to determine which consent procedure patients prefer for use of stored tissue for research purposes and what the effects of consent procedures on actual consenting behaviour are.METHODS: We offered 264 cancer patients three different consent procedures: 'one-time general consent' (asked written informed consent), 'opt-out plus' (had the opportunity to opt ou
The purpose of this proof-of-concept study was to develop three-dimensional patient-specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with anterior cruciate ligament (ACL) reconstructed knees were imaged at 1 and 3 years after surgery. The magnetic resonance imag
The High-Resolution Spectrometers in Hall A at Jefferson Laboratory have been instrumented with state-of-the-art Vertical Drift Chambers designed and constructed by the Nuclear Interactions Group at MITLNS in conjunction with the Physics Division at Jefferson Lab. These chambers rely on a unique, high cell-density design made possible by the absence of field-shaping wires. Each chamber has an inhe
Viral infections predispose to the development of childhood asthma, a disease associated with increased lung mast cells (MCs). This study investigated whether viral lower respiratory tract infections (LRTIs) can already evoke a MC response during childhood. Lung tissue from young children who died following LRTIs were processed for immunohistochemical identification of MCs. Children who died from
Although cryptococcal infections due to Cryptococcus neoformans are frequently reported in the immunosuppressed patients, infections related to other Cryptococcus spp. are rarely reported. We are reporting a case of pulmonary infection and ARDS due to C. albidus in a patient receiving immunosuppressive therapy because of Still's disease. The diagnosis was made by tissue biopsy and culture. The pat
Ever since its introduction 40 years ago l-3,4-dihydroxyphenylalanine (l-DOPA) therapy has retained its role as the leading standard medication for patients with Parkinson's disease. With time, however, the shortcomings of oral l-DOPA treatment have become apparent, particularly the motor fluctuations and troublesome dyskinetic side effects. These side effects, which are caused by the excessive sw
Impaired beta-cell function is key to the development of type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties. Here we studied the role of endogenous CART in beta-cell function. CART silencing in INS-1 (832/13) beta-cells reduced insulin secretion and production, ATP levels and beta-cell exocytosis. This was su
Cannabinoid receptors 1 (CB1) and/or 2 (CB2) are overexpressed in many types of human malignancies including mantle cell lymphoma (MCL). Agonists to CB1 and CB2 promote ceramide de novo synthesis, p38-mitogen-activated protein kinase-dependent activation of caspase-3 and apoptotic cell death in most MCLs. However, in this report we describe that in some MCLs the response to treatment with cannabin
PURPOSE: To evaluate the outcomes of total endovascular aortic arch repair using three-vessel inner branch stent-grafts for aneurysms and chronic dissections.METHODS: We reviewed the clinical data and outcomes of consecutive patients treated by total endovascular aortic arch repair at eight academic centers using three-vessel inner branch stent-grafts (William Cook Europe, Bjaeverskov, Denmark) be
Calcium channels must be subjected to a very precise regulation in order to preserve cell function and viability. Voltage gated calcium channels (VGCC) represent the main pathway for calcium entry in excitable cells. This explains why depolarization induces a rapid-onset and short-term inactivation of calcium currents. Contrarily to this well-documented mechanism to maintain calcium below toxic le
I denna studie analyseras potentialen för en ökad tillförsel av biomassa från skog, jordbruk och akvatiska system i Sverige baserat på en sammanställning och bearbetning av aktuella potentialstudier. Analysen inkluderar tekno-ekonomiska begränsningar och minimering av risker för miljömålskonflikter vid en ökad produktion av biomassa. Dessutom analyseras potentialen för en ökad avsättning av biomas
The presence of 5-methyluridine (m5U) at position 54 is a ubiquitous feature of most bacterial and eukaryotic elongator tRNAs. In this study, we have identified and characterized the TRM2 gene that encodes the tRNA(m5U54)methyltransferase, responsible for the formation of this modified nucleoside in Saccharomyces cerevisiae. Transfer RNA isolated from TRM2-disrupted yeast strains does not contain
The evolution of reading frame maintenance must have been an early event, and presumably preceded the emergence of the three domains Archaea, Bacteria and Eukarya. Features evolved early in reading frame maintenance may still exist in present-day organisms. We show that one such feature may be the modified nucleoside 1-methylguanosine (m(1)G37), which prevents frameshifting and is present adjacent
Broar över vattendrag utgör viktiga element i många transportsystem. Om broar kollapsar orsakas betydande problem med både direkta och indirekta kostnader för samhällsekonomin. Lokal erosion av botten kring broar är många gånger en huvudorsak till brokollaps, ofta i samband med extrema flödessituationer. Risken för sådan lokal erosion kan bli större i samband med en framtida klimatförBridges are important components in many transportation networks often spanning rivers and other water bodies. The failure of a bridge will cause significant direct and indirect economic losses to society. Scouring of the river bed around bridges is a principal mode of bridge failure typically associated with large floods. The risk of such scour may become higher with the emerging climate chang
AIM: To study the cellular transport of L68Q cystatin C, the cystatin variant causing amyloidosis and brain haemorrhage in patients suffering from hereditary cystatin C amyloid angiopathy (HCCAA).METHODS: Expression vectors for wild-type and L68Q cystatin C were constructed and used to transfect mouse NIH/3T3 cells. Stable cell clones were isolated after cotransfection with pSV2neo. Clones express
Bacterial reverse transcriptases (RTs) are a large and diverse enzyme family. AbiA, AbiK and Abi-P2 are abortive infection system (Abi) RTs that mediate defense against bacteriophages. What sets Abi RTs apart from other RT enzymes is their ability to synthesize long DNA products of random sequences in a template- and primer-independent manner. Structures of AbiK and Abi-P2 representatives have rec
Denna rapport utgör Klimatpolitiska rådets årliga utvärdering av regeringens samlade politik i förhållande till de klimatmål som beslutats av riksdag och regering.Del I är en utvärdering av hur regeringens politik har utvecklats under 2024 och har alltså en tidsmässig avgränsning. För att sätta den utvärderingen i ett sammanhang inleds texten men en kortfattad genomgång av nu gällande klimatmål oc
Drawing on political readings of Freud, this paper probes the anxieties and fears driving anti-gender consumer activism, an emerging form of consumer politics in which a cisheteronormative subject defends his consumer privileges in the name of “the family.” We examine how American anti-gender activists opposed Disney’s shift from its conservative, family-oriented brand image. We argue that this ca
Popular Abstract in Swedish Hydrogen holds a great promise as an efficient and clean future energy carrier due to its high energy density and lack of pollutant generation. Anaerobic degradation of organic substrates by heterotrophic microorganisms enables the production of hydrogen from a wide spectrum of agricultural feedstock and waste products. Using thermophiles in this process is preferable fHydrogen holds a great promise as an efficient and clean future energy carrier due to its high energy density and lack of pollutant generation. Anaerobic degradation of organic substrates by heterotrophic microorganisms enables the production of hydrogen from a wide spectrum of agricultural feedstock and waste products. Using thermophiles in this process is preferable for maximizing the substrate
This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book focuses on internal displacement in the context of disasters and climate change in Asia and the Pacific. It brings the role of disaster risk reduction and management authorities, as well as legal and policy frameworks that regulate their conduct, more into focus than the role of o
