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The occurrence of clonal chromosome aberrations in short-term cultures from synovia, osteophytes, and cartilage from patients with osteoarthritis (OA) was recently reported. Among these aberrations, a recurrent involvement of chromosome bands 12q13-15 in structural rearrangements was detected in both synovia and osteophytes. Chromosomal abnormalities of 12q13-15 are frequent among malignant and be
Abstract in French L’effet de la courbure interfaciale sur le point de congélation de liquides retenus dans des capillaires permet, en principe, de déterminer une distribution du diamètre des pores, d’après la courbe point de congélation/volume congelé. On procède à un examen des bases théoriques et l’on montre qu’il existe une similitude formelle avec les méthodes par condensation capillaire qui By utilising the effect of interfacial curvature on the freezing-point of liquids confined in capillaries, it is in principle possible to determine a pore-size distribution, from the curve of freezing-point against volume frozen. The method is formally similar to capillary condensation methods based on the Kelvin equation. Suitable experimental techniques are described. A comparison with the resul
The International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology convened during the International congress in Cancun, July 2012. This report details the newly identified antigens in existing blood group systems and presents three new blood group systems.
Is overweight associated with impaired sperm DNA integrity?
I denna studie analyseras potentialen för en ökad tillförsel av biomassa från skog, jordbruk och akvatiska system i Sverige baserat på en sammanställning och bearbetning av aktuella potentialstudier. Analysen inkluderar tekno-ekonomiska begränsningar och minimering av risker för miljömålskonflikter vid en ökad produktion av biomassa. Dessutom analyseras potentialen för en ökad avsättning av biomas
Drawing on political readings of Freud, this paper probes the anxieties and fears driving anti-gender consumer activism, an emerging form of consumer politics in which a cisheteronormative subject defends his consumer privileges in the name of “the family.” We examine how American anti-gender activists opposed Disney’s shift from its conservative, family-oriented brand image. We argue that this ca
Determinants of differentiation and apoptosis in myelomonocytic leukemia cells (U937) exposed to the novel hybrid polar compound SAHA (suberoylanilide hydroxamic acid) have been examined. In contrast to hexamethylenbisacetamide (HMBA), SAHA-related maturation was limited and accompanied by marked cytoxicity. SAHA-mediated apoptosis occurred within the G0G1 and S phase populations, and was associat
COVID-19 is a major public health threat associated with increased disease burden, mortality, and economic loss to countries and communities. Safe and efficacious COVID-19 vaccines are key in halting and reversing the pandemic. Low confidence in vaccines has been one of the factors leading to hesitancy. We aimed to assess the COVID-19 vaccine confidence (safety and effectiveness), associated facto
This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book focuses on internal displacement in the context of disasters and climate change in Asia and the Pacific. It brings the role of disaster risk reduction and management authorities, as well as legal and policy frameworks that regulate their conduct, more into focus than the role of o
Maternal smoking in pregnancy may increase the risk of testicular germ cell cancer (TGCC) in offspring, but current evidence remains inconclusive. We performed a nested case-control study using cotinine measurements in maternal serum and amniotic fluid as a biomarker for tobacco exposure during pregnancy. A total of 654 males with maternal serum (n = 359, ncases/controls = 71/288) and/or amniotic
The purpose of this proof-of-concept study was to develop three-dimensional patient-specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with anterior cruciate ligament (ACL) reconstructed knees were imaged at 1 and 3 years after surgery. The magnetic resonance imag
Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial toxin-antitoxin systems that pyrophosphorylate the 3'-CCA end of transfer RNA (tRNA) to prevent aminoacylation. toxSAS are implicated in antiphage immunity: Phage detection triggers the toxSAS activity to shut down viral production. We show that the toxSAS FaRel2 inspects the tRNA acceptor stem to specifical
Calcium channels must be subjected to a very precise regulation in order to preserve cell function and viability. Voltage gated calcium channels (VGCC) represent the main pathway for calcium entry in excitable cells. This explains why depolarization induces a rapid-onset and short-term inactivation of calcium currents. Contrarily to this well-documented mechanism to maintain calcium below toxic le
Popular Abstract in Swedish Hydrogen holds a great promise as an efficient and clean future energy carrier due to its high energy density and lack of pollutant generation. Anaerobic degradation of organic substrates by heterotrophic microorganisms enables the production of hydrogen from a wide spectrum of agricultural feedstock and waste products. Using thermophiles in this process is preferable fHydrogen holds a great promise as an efficient and clean future energy carrier due to its high energy density and lack of pollutant generation. Anaerobic degradation of organic substrates by heterotrophic microorganisms enables the production of hydrogen from a wide spectrum of agricultural feedstock and waste products. Using thermophiles in this process is preferable for maximizing the substrate
I Sverige kommer ungefär 2-3 % av befolkningen någon gång att drabbas av paniksyndrom med eller utan agorafobi (PS/A), ett tillstånd som består av plötsliga, oväntade panikattacker som följs av ihållande rädsla för nya attacker och/eller betydande livsstilsförändringar. PS/A debuterar oftast i slutet av tonåren eller i tidig vuxenålder och ger om den förblir obehandlad ofta kroniska psykiska besväApproximately 2-3% of adults in Sweden will experience unexpected panic attacks that cause them to develop fears of future attacks and to alter their lives, defined as Panic Disorder with or without Agoraphobia (PD/A). The condition often onsets in late adolescence or early adulthood, with high levels of psychiatric comorbidity, social difficulties, diminished study and work ability, an elevated r
While leukocyte interferon was found therapeutically ineffective in a series of 20 patients with metastatic malignant melanoma, subsequent combination treatment with interferon and cimetidine induced 5 complete and 1 partial tumour remissions. Prior to interferon therapy initiation, regressor patients demonstrated a significantly greater ability to mediate antibody-dependent cellular cytotoxicity
Much of our built environment is constructed to accommodate ‘normate’ (Garland-Thomson 1996; Hamraie 2017) bodies. This fact may remain invisible to normate users of public space, much as the ordering of human interaction through categorisation is often invisible (Bowker & Star 1999). Reading semiotic landscapes through the dis/abling (Campbell 1999) of bodies that (attempt to) move through thMuch of our built environment is constructed to accommodate ‘normate’ (Garland-Thomson 1996; Hamraie 2017) bodies. This fact may remain invisible to normate users of public space, much as the ordering of human interaction through categorisation is often invisible (Bowker & Star 1999). Reading semiotic landscapes through the dis/abling (Campbell 1999) of bodies that (attempt to) move through th
The purpose of this study was to evaluate the effects of two alternative chemotherapy regimes on the quality of life (QoL) of patients with advanced breast cancer. In a multicentre trial, 283 patients were randomised to receive either docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). QoL was assessed at baseline and before each treatment using the European Organization for Research
The present study examined the relationship between childhood socioeconomic status (SES), childhood maltreatment, and the volumes of the hippocampus and amygdala between the ages of 25 and 36 years. Previous work has linked both low SES and maltreatment with reduced hippocampal volume in childhood, an effect attributed to childhood stress. In 46 adult subjects, only childhood maltreatment, and not
