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The study describes the first glycoside hydrolase that exhibits comparable levels of activity on α- and β-linked saccharide substrates. This enzyme, assigned into GH109, is encoded by the genome of the human gut symbiont Akkermansia muciniphila that is a model primary degrader of the heavily O-glycosylated mucin glycoprotein that coats the epithelial enterocytes.The elusive catalytic acid/base cat
Enzymes active on glycosidic bonds are defined according to the stereochemistry of both substrates and products of the reactions they catalyze. The CAZy classification further assigns these enzymes into sequence-based families sharing a common stereochemistry for substrates (either α- or β-) and products (i.e., inverting or retaining mechanism). Here we describe the N-acetylgalactosaminidases AmGH
Results of a search for new phenomena in events with an energetic photon and large missing transverse momentum with the ATLAS experiment at the Large Hadron Collider are reported. The data were collected in proton-proton collisions at a centre-of-mass energy of 13 TeV and correspond to an integrated luminosity of 3.2 fb−1. The observed data are in agreement with the Standard Model expectations. Ex
A search is presented for dark matter produced in association with a hadronically decaying W or Z boson using 3.2 fb-1 of pp collisions at √ s = 13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with a hadronic jet compatible with a W or Z boson and with large missing transverse momentum are analysed. The data are consistent with the Standard Model predictions and are inte
Background: Socioeconomic status and geographical factors are associated with health and use of healthcare. Well-performing primary care contributes to better health and more adequate healthcare. In a primary care system based on patient's choice of practice, this choice (listing) is a key to understand the system. Objective: To explore the relationship between population and practices in a primar
Background: Enabling women to make informed decisions is a key objective in the guidelines governing prenatal screening and diagnostics. Despite efforts to provide information, research shows that women's choice of prenatal screening is often not based on informed decisions. The aim of this study was to investigate pregnant women's perceptions of the use of an interactive web-based DA, developed t
The cross-section for the production of two jets in association with a leptonically decaying Z boson (Zjj) is measured in proton–proton collisions at a centre-of-mass energy of 13 TeV, using data recorded with the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 3.2 fb−1. The electroweak Zjj cross-section is extracted in a fiducial region chosen to enhance
This study is devoted to the calibration of a backpack radiation detection system (BPRDS) for evaluation of the external dose to a person staying in an environment contaminated by 137Cs. A commercially available portable gamma-ray spectrometer-dosemeter based on a NaI(Tl) detector was used. By means of information in the pulse-height distribution, it has been possible to separate the technogenic a
Cambodian migrants in the Thai construction sector, work in precarious working environments, with limited safety conditions and low wages. The use of social protection schemes has increased in recent decades, as a method of reducing the vulnerable against poverty and livelihood risks. However, despite the transformative potential of social protection, migrant workers face difficulties in accessing
Buildings account for 40% of energy use and about one third of CO2 emissions in the EU. The huge energy saving potentials offered by the building sector has been targeted by a large number of policy instruments. To improve policy intervention in this area, more information on the extent to which the applied policy instruments are supporting the development and dissemination of different types of e
The majority of approaches for mass appraisal are based on global statistical models that take into account property characteristics, and, in developing countries, location variables are not often explicitly considered. The present study uses Geographic Information Systems (GIS) as an analytical tool to develop a number of location variables and to analyze their impact in the value of properties.
This study aims to evaluate the usability of ecotope maps to predict aquatic ecological consequences of floodplain landscape changes. If successful, this method will be applied to evaluate ecological rehabilitation measures that will be carried out in order to improve the ecological status of the large river plains. Ecological value is reflected in indicator metrics for fish, aquatic vegetation, a
This study employs an approach to policy as discourse and examines the construction of gender equality in the EU Gender Action Plan II. Drawing from the poststructural premise that discourses affect how issues are being thought about and acted upon, the study seeks to scrutinize how gender equality is attributed with meaning by applying Carol Bacchi’s analytical methodology What’s the problem repr
Corporations and in particular large multinational enterprises are important for every countries economic growth. However, exploitation and human rights abuses due to corporate activity are repeatedly occurring in states that lacks the proper legislation, enforcement or institutions to ensure human rights protection. Thus, there is an increasing call for lead firms of MNEs to exercise human rights
One of the target goals for sustainable development is the reduction of maternal mortality, which is a big health issue in some countries. Even if the research on maternal health care has come far and with the right expertise and supplies, almost all maternal deaths would be preventable. A working force to reduce the issues within maternal mortality in many countries are non-governmental organizat
