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The chemokine CCL25 is selectively and constitutively expressed in the small intestinal epithelium and plays an important role in mediating lymphocyte recruitment to this site. In this study, we demonstrate that CCL25 expression in murine small intestinal epithelial cells is independent of signaling through the lymphotoxin 0 receptor and is not enhanced by inflammatory stimuli, pathways involved i
We previously identified matrilin-2 (MATN2), the largest member of the novel family of matrilins. These filament-forming adapter proteins expressed in a distinct, but partially overlapping, pattern in all tissues were implicated in the organization of the extracellular matrix. Matrilin-2 functions in a great variety of tissues. Here, we present the genomic organization of the highly conserved mous
Capacitance measurements were applied to mouse pancreatic beta-cells to elucidate the cellular mechanisms underlying biphasic insulin secretion. We report here that only <50 of the beta-cell's >10,000 granules are immediately available for release. The releasable granules tightly associate with the voltage-gated alpha(1C) Ca(2+) channels, and it is proposed that the release of these granules accou
Comparisons of PIXE detection limits for K, X rays using 2-5 MeV protons and 7-8 MeV 4He2+ ions as projectiles have been performed. The comparisons have been made for common aerosol backings. According to simple theoretical considerations regarding X-ray production cross sections and the production of background radiation, detection limits for 4He2+ should be two to four times lower than for proto
A European Union (EU) directive on vitamins and minerals used as ingredients of food supplements with a nutritional or physiological effect (2002/46/EC) was introduced in 2003. Its implications for the use of oral supplements of calcium and vitamin D in the prevention and treatment of osteoporosis were discussed at a meeting organized with the help of the World Health Organization ( WHO) Collabora
A typical feature of the boreal forest landscape is a gradient from dry to wet sites, with associated increases in the depth of the soil organic layers. In this study, the coupled ecosystem-soil biogeochemistry model GUESS-ROMUL is used to explore how the specific features of soil organic matter decomposition and vegetation dynamics account for an observed difference between the soils formed under
Human factors certification criteria are being developed for large civil aircraft with the objective of reducing the incidence of design-induced error on the flight deck. Many formal error identification techniques currently exist which have been developed in nonaviation contexts but none have been validated for use to this end. This paper describes a new human error identification technique (HET
The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The eff
Simulated moving bed (SMB) technology is a continuous chromatographic technique proven to have many advantages compared to conventional batch chromatography, such as: raised productivity and product concentration, reduced buffer consumption as well as more efficient use of raw material. In this study a 20 column SMB process for the separation of lactoperoxidase and lactoferrin from whey protein co
The results of Swanson and Avanta metacarpophalangeal joint arthroplasties in rheumatoid patients were compared in a prospective, randomized study of 30 patients (120 implants). At 2-year follow-up, grip strength was measured, hand function was assessed with the Sollerman test and the subjective outcome was determined with visual analogue scores. With both implants ulnar deviation and flexion defo
There are four peptidyl-proline bonds in the 64-residue protein chymotrypsin inhibitor 2 (CI2), all of which are in the trans conformation in the native structure. The isomerisation of one or more of these peptidyl-proline bonds to the cis conformation in the denatured state gives rise to heterogeneity, leading to both fast and slow-folding species. The refolding of the fast-folding species, which
1. The European Water Framework Directive requires the determination of ecological status in European fresh and saline waters. This is to be through the establishment of a typology of surface water bodies, the determination of reference (high status) conditions in each element (ecotype) of the typology and of lower grades of status (good, moderate, poor and bad) for each ecotype. It then requires
Removal of Ca2+ from PSII lead to impaired electron transfer from YZ to P680+ and to inhibition of S state transitions which results in a modified stable S2 state (probed by a stable multiline EPR signal) and the induction of the S2YZox state ("split" signal) by illumination at 0° C. We have performed an EPR study on the pH dependence of these reactions in Ca2+-depleted PSII (prepared by citrate t
When designing fire safety of buildings the fire growth rate is an important parameter, in large affecting the overall fire safety level within the building. Generally, a deterministic fire growth rate is used raising the question whether the resulting design arrives at a reasonable level of safety. A method was developed to obtain distributions of fire growth rates in specific building types.
