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This chapter analyses the role that 'ordre public' and morality exceptions can play in the granting of patents on inventions in the field of human germline editing and the consequences of this policy option. In order to provide the context for such an analysis, the chapter will, first, provide an overview of the current patent landscape for relevant genome editing technologies, drawing attention t
Many forensic psychiatric inpatients have difficulties regulating aggressive behavior. Evidence of effective aggression treatments is limited. We designed and investigated the effectiveness of a transdiagnostic application of a virtual reality aggression prevention training (VRAPT). In this randomized controlled trial at four Dutch forensic psychiatric centers, 128 inpatients with aggressive behav
Students in a country like Ethiopia face a double air pollution challenge: they are frequently exposed (both outdoors and indoors) to sources of incomplete combustion and therefore to unhealthy concentrations of particulate matter (PM2.5) and carbon monoxide (CO), while they also face increased carbon dioxide (CO2) concentrations in crowded dormitories and classrooms. Research on air pollution in
Background: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been shown to reduce rates of heart failure hospitalisations and cardiovascular death in patients with type 2 diabetes and prior cardiovascular disease. We hypothesised that SGLT2 inhibitors could provide cardiovascular benefits in the post-myocardial infarction setting. We aimed to investigate cardiovascular outcomes of SGLT2 inh
Finding direct records of the ancient Earth's atmosphere is key to understand the evolution of the entire planet. Nevertheless, such records are scarce, and only a few geological samples with preserved paleo-atmospheric signatures are available today. In this study, we analyzed noble gases contained in shocked granitic and volcanic rocks collected across the 380 Ma-old Siljan impact structure (in
The deterioration of fibre-reinforced sprayed concrete was studied in the Oslofjord subsea tunnel (Norway). At sites with intrusion of saline groundwater resulting in biofilm growth, the concrete exhibited significant concrete deterioration and steel fibre corrosion. Using amplicon sequencing and shotgun metagenomics, the microbial taxa and surveyed potential microbial mechanisms of concrete degra
Research focus in environmental pollution has recently been extended from more classical environmental pollutants such as PCBs or pesticides to pharmaceuticals and steroid hormones, which are designed to be biologically active and enter the environment primarily through regular domestic use. Consequently, it is important to monitor these substances concentrations in the effluents of sewage treatme
BACKGROUND: The Swedish school-based vaccination programme offers HPV vaccine to girls born ≥1999 in 5-6th grade. In 2012, all counties introduced free-of-charge catch-up vaccination campaigns targeting girls born 1993-1998. Varying vaccine uptake in the catch-up group by December 2012 suggested that some implementation strategies were more successful than others. In order to inform future vaccina
Objectives To investigate the relation between patient characteristics at rheumatoid arthritis (RA) diagnosis and subsequent initiation of treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) or targeted synthetic DMARDs (tsDMARDs). Design A retrospective cohort study. Setting and participants Consecutive patients (N=330) with early RA (symptom duration <12 months) diagnosed at
This paper investigates and discusses four instruments found in a sixteenth century Spanish book of navigation. The night clock is a rather standard application of similar instruments known since the fourteenth century in Europe. Cortés’ explanation of the causes of the deviation of the magnetic and geographical north is quite original. His instrument to correct for that the Polaris deviates from
Since 1958, cell culture media supplemented with fetal bovine serum is used, despite the well-known concerns about animal welfare, reproducibility, reliability, relevance, and safety. To obliterate these concerns and increase scientific accuracy, we recently published an open access, publicly available paper on a defined medium composition to make it possible for any lab to prepare this medium. Th
The United Nations (UN) Intergovernmental Negotiating Committee (INC) has completed its second round of negotiations on a new international legally binding instrument to ‘end plastic pollution’. This paper examines the results of the second session of negotiations, which took place May 29–June 2, 2023, and analyses the trends, barriers, and themes shaping the emerging legally binding instrument. T
Carpal tunnel syndrome (CTS) occurs more often among individuals with diabetes. The aim of this retrospective observational registry study was to examine whether individuals with diabetes and CTS are treated surgically to the same extent as individuals with CTS but without diabetes. Data on CTS diagnosis and surgery were collected from the Skåne Healthcare Register (SHR). A total of 35,105 individ
The xylonate was bioproduced directly from lignocellulosic residues, and the application properties of crude xylonate powder were investigated with a promising potential as a bio-based concrete water reducer. The overall integrated process was evaluated on the view of mass balance and techno-economic analysis using Aspen Plus modeling. 56 g/L of calcium xylonate (XA-Ca) can be obtained within 8 h
Rushed efforts for a decarbonisation of the energy sector in Catalonia, Spain have been received with local opposition towards renewable energy projects. It has also raised a debate around the new energy model and whether it will perpetuate the lack of agency of civil society in the energy sector as well as the vulnerable situation some people are currently facing. This thesis examines whether ren
If people understand how social media works, as an important new element of mass media, they can use social media advertising and social network strategies as a tool for helping environmental awareness in societies and communities. Social media can work as a tool to help consumers and companies detect when companies use greenwashing in their campaigns and in the information delivered about their p
Sierra Leone has struggled with high rates of adolescent pregnancy for some time and reports have shown an increase in these figures during and following the unprecedented Ebola Virus Disease outbreak from 2014 through 15. As young girls are impregnated, it has long been customary for girls to drop out of school. When schools re-opened after the Ebola crisis, this practice was formalized as the Mi
Regelverk på nationell och internationell nivå som syftar till att uppmuntra och underlätta internationella investeringar och handel möjliggör idag för multinationella företag att verka transnationellt genom användning av filialer och dotterbolag. När det kommer till företagsbeskattning har avsaknaden av ett globalt och universellt skattesystem för att reglera internationella skattefrågor dock möjDomestic and international regulations aiming to facilitate international trade and investment today enable multinational corporations (MNCs) to operate transnationally through the use of branches or subsidiary companies. Within the field of corporate taxation, the lack of a global and universal tax system regulating international tax matters however allows MNCs to exploit gaps and loopholes withi
