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BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent.OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension.METHODS: In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥2 p
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with mortality rates between 30-50%. Although in vitro models replicate some aspects of ARDS, small and large animal models remain the primary research tools due to the multifactorial nature of the disease. When using these animal models, histology serves as the gold standard method to confirm lung injury and exclude other
Do virtual representations, intended for teaching and learning, afford different constraints and affordances compared to their physical twins, and may this lead to different ways of interaction and understanding? In this line of inquiry, and with the perspective on learning as an extended activity, where learning can be mediated through the interaction with artefacts, the present study has transla
BACKGROUND: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with type 2 diabetes (T2D).METHODS: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that could improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outco
On 5 January 2023, the Swedish Government announced the decision to introduce new restrictions to enter Sweden: due to the spread of Covid-19 in China, travellers from this direction need to show negative Covid-test results. In cases when there is no possibility of showing the results, the travellers are not allowed to enter Sweden. Governmental Ordinance (2023:2) was temporary and lasted from 7 J
Socio-culturally formed collegial contexts in the midlevel of higher education organizations have attracted increased attention from higher education researchers. It is assumed that development, change and stability are dependent on norms, habits and traditions in these contexts. This text introduces a framework useful for identifying and investigating these collegial contexts. The framework is ap
OBJECTIVE:: Cartilage oligomeric matrix protein (COMP) is a structural component of cartilage where it catalyzes collagen fibrillogenesis. Elevated amounts of COMP are found in serum during increased turnover of cartilage associated with active joint diseases, such as rheumatoid arthritis (RA) and osteoarthritis (OA). In this study we investigated the ability of COMP to regulate complement. Such c
Background: High fasting plasma proneurotensin concentration was associated with the development of breast cancer in the Malmö Diet and Cancer Study (MDCS). Here we aimed at replicating the initial finding in an independent second cohort. Methods: The Malmö Preventive Project (MPP) is a population study and comprised 18 240 subjects when examined 2002-2006. Of women without history of breast cance
All patients with palliative and end of life care needs should be guaranteed equal and safe treatment and care, regardless of their disease or site of care. The inclusion of quality indicators in national guidelines and other guiding documents supports quality assurance and improvement in provision of care. The aim of this paper was to review existing quality indicators in national Swedish policy
Prevalence data on radiographic osteoarthritis (ROA) in young active athletes is sparse. Aim was to assess in a matched case-control design the frequency of ROA in an athlete population and whether athlete status, gender, previous anterior cruciate ligament (ACL) surgery and age increase the odds for ROA.
Abstract in Undetermined ABSTRACT. Optical techniques for tissue diagnostics currently are experiencing tremendous growth in biomedical applications, mainly due to their noninvasive, inexpensive, and real-time functionality. Here, we demonstrate a hand-held fiber optic probe instrument based on fluorescence/reflectance spectroscopy for precise tumor delineation. It is mainly aimed for brain tumor
In high-income countries, non-communicable diseases drive the demand for surgical healthcare. Middle-income countries face a double disease burden, of both communicable and non-communicable disease. The aim of this study was to describe the role of surgery for the in-hospital care of infectious conditions in the high-income country Sweden and the middle-income country South Africa.
A fully divergence-free method is proposed for generation of inhomogeneous/anisotropic turbulence with large spatial variation. The method is based on the method of Smirnov et al., which is known to violate the divergence-free constraint when spatial variation of turbulence is present. In the proposed method a vector potential field is introduced; by taking the vector curl of the potential field o
Background: Virtual imaging trials (VITs) are in silico studies that simulate medical imaging and disease processes, offering a cost-effective and reproducible addition to traditional imaging trials. While VITs are well established in breast imaging, most existing implementations simulate imaging based on static anatomical models, capturing only a single time point. This limits their ability to st
This paper explores the legal relevance of delusions in determining criminal responsibility. We argue that although delusions may be relevant in assessing capacity for criminal responsibility, the specific content of delusional beliefs should not form the basis for judgments of blameworthiness. The analysis takes the Anglo-American criminal law tradition as its starting point, focusing on the geneThis paper explores the legal relevance of delusions in determining criminal responsibility. We argue that although delusions may be relevant in assessing capacity for criminal responsibility, the specific content of delusional beliefs should not form the basis for judgments of blameworthiness. The analysis takes the Anglo-American criminal law tradition as its starting point, focusing on the gene
This chapter will describe how educators can use uncertainty field books to explore students’ experiences as they navigate in complex and uncertain knowledge and information spaces, to engage others, and to start, grow and sustain movements for change using the groaning in the groan zone. In describing the field book, method and practice, but foremost students’ narratives, the chapter sets it up a
This study evaluated the adaptation of relapse prevention treatment, originally for substance use, to address problematic gaming in children and adolescents. The goal was to understand the feasibility of this treatment in child and adolescent mental health services from the clinicians’ perspective. Six clinicians, four women and two men aged 37–47 with 4–20 years of work experience, were interview
Multidimensional diffusion MRI is a promising new MRI approach that has the potential to non-invasively give information about brain microstructure at an unprecedented level of detail. The present contribution briefly reviews the salient features of the novel method, its historical background and differences with conventional methods, as well as the remaining challenges that have to be overcome in
Background: Following the results of the MANDARA trial, this real-life study aimed at comparing the effectiveness and safety profile of mepolizumab versus benralizumab in a European EGPA cohort. Methods: We conducted a retrospective observational comparative study including EGPA patients, who received mepolizumab or benralizumab at the asthma dose. Patients were matched 1:1 by sex, age, BVAS and o
