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Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is known regarding the biology underlying this symptom. We conducted a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP). Adults of European ancestry were included from 15 cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and from th
OBJECTIVE: We investigated potential interactions between body mass index (BMI) and genotypes of human leukocyte antigen (HLA), TCF7L2-rs7903146, and FTO-rs9939609 in relation to the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes. METHODS: We pooled data from two population-based studies: (i) a Swedish study with incident cases of LADA [positive for glutamic acid decarboxy
Background: Fetal growth restriction (FGR) is a serious obstetric condition for which there is currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish a well phenotyped bio-bank. The findings will provide up-to-date information for clinicians and patients and inform the design and c
It is possible to disagree on nearly everything when it comes to human agency. Nonetheless, certain things are written in stone. One thinks. One acts. One makes mistakes. My focus in this dissertation is on these three simple facts and the relation between them. I am fascinated by the different roles that knowledge plays with each: that is, the kind of knowledge one has of thoughts, actions, and m
Objective. To describe the change of pain reports over time in 3 cohorts derived from the general population: (1) no chronic pain (NCP, n = 1156); (2) chronic regional pain (CRP n = 502) and (3) chronic widespread pain (CWP; n = 242). To identify risk factors that predict the development or persistence of chronic widespread pain. Methods. A 3-year followup from 1995 to 1998 with postal questionnai
Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers o
Popular Abstract in Swedish Avhandlingen behandlar den svenska fotbollens kulturhistoria från 1800-talets slut fram till år 1950. Det är berättelsen om hur spelet gradvis etableras, överkommer en mängd inre och yttre problem och konflikter, för att träda in i sin guldålder under 1940-talet. Mer konkret följs hur fotbollens medelklassdominerade maktelit försökte kontrollera skeendet inom en sport pThis thesis concerns Swedish football´s cultural history from the end of the nineteenth century to 1950. It is the story of how the game was gradually established, and overcame a great number of internal and external problems and conflicts, before entering its sporting and cultural golden age during the 1940s. I demonstrate how this game´s middle-class dominated power elite tried to control the de
Objective: To evaluate the effects of low-dose prostacyclin on intestinal perfusion during endotoxemia. Design: A randomized, blinded experimental study. Setting: A university laboratory. Subjects: Sixteen anesthetized cats. Interventions: The animals received endotoxin by continuous intravenous infusion (0.5 mg/kg plus 0.5 mg kg(-1).hr(-1)) and a continuous volume replacement throughout the exper
Ansträngningsutlöst andningsfunktionsstörning drabbar främst barn och ungdomar, oftast i samband med idrottsutövning och är vanligare bland flickor än pojkar. Mekanismerna bakom besvären är komplexa och inte helt klarlagda. Enhetliga rutiner för omhändertagandet finns inte. Syftet med uppsatsen var att kartlägga och utvärdera omhändertagandet av personer med dessa besvär vid Röst- och TalvårdsavdeExercise-induced respiratory dysfunction affects mostly children and young people, usually during athletic performance, and is more common among girls than boys. The mechanisms of the disorder are complex and not fully understood. Uniform clinical procedures for examination and treatment of these patients are not established. The purpose of this paper was to identify and evaluate the present care
This thesis deals with how the Swedish EU membership has been regulated constitutionally. Although the EU membership arguably has had profound effects on Swedish public policymaking very little about this is mentioned in the constitution. How can that be? The inquiry is made more relevant by the fact it has been described as an “elephant in the room” – an obvious problem that no one wants to discu
Background: Whether long-term effectiveness differs between anti-tumour necrosis factor (anti-TNF) agents is unknown. Aims: To examine drug survival of first-line anti-TNF agents and identify predictors of discontinuation. To reduce channelling bias, we also compared drug survival of the second anti-TNF. Methods: Biologic-naïve patients (N = 955) recorded in the Swedish IBD Quality Register (SWIBR
Background Patient crowding in emergency departments (ED) is a common challenge and associated with worsened outcome for the patients. Previous studies on biomarkers in the ED setting has focused on identification of high risk patients, and and the ability to use biomarkers to identify low-risk patients has only been sparsely examined. The broader aims of the TRIAGE study are to develop methods t
Background: [18F]PSMA-1007 is a promising tracer for integrated positron emission tomography and computed tomography (PET/CT). Objective: Our aim was to assess the diagnostic accuracy of [18F]PSMA-1007 PET/CT for primary staging of lymph node metastasis before robotic-assisted laparoscopy (RALP) with extended lymph node dissection (ePLND). Design, Setting and Participants: The study was a retrospe
BACKGROUND: In patients with chronic coronary syndrome undergoing percutaneous coronary intervention, the optimal timing of P2Y12 inhibitors' administration is uncertain. We compared pretreatment versus treatment in the catheterization laboratory (In-Cathlab) in a real-world population. METHODS: In Swedish Coronary Angiography and Angioplasty Registry, all patients with chronic coronary syndrome u
A popular uprising in 2014, led to a revolution that overthrew the sitting President of Burkina Faso. We investigate if individuals' risk attitudes changed due to this revolution. We examine this impact by the main determinants of risk attitudes: gender, age and level of education. The analysis is based on unique panel survey data, allowing us to track the changes in the risk attitudes of the same
Background: People with aphasia (PWA) after ischemic stroke often have difficulties in communication and social participation. To individualise rehabilitation and optimise recovery, there is a need for knowledge regarding prevalence of aphasia, and language functions in relation to long-term recovery and health-related quality of life (HRQoL). In this study, we examined these issues in a Swedish s
PURPOSE: The Obesity and Disease Development Sweden (ODDS) study was designed to create a large cohort to study body mass index (BMI), waist circumference (WC) and changes in weight and WC, in relation to morbidity and mortality.PARTICIPANTS: ODDS includes 4 295 859 individuals, 2 165 048 men and 2 130 811 women, in Swedish cohorts and national registers with information on weight assessed once (2
Companies always strives to acheive as eective inventory control as possible. At the same time, a suciently high delivery accuracy to satisfy the customer is pursued. One prerequisite for successfully accomplishing this is to anticipate customer demand in advance. An approximation of the demand in advance is called forecasting. Forecasting implies that dierent techniques are used to predict future
This study investigates teachers’ perspectives on the use of gamification in programming courses at Lund University’s Faculty of Engineering (LTH), focusing on implementation within the Moodle learning platform. Using a qualitative approach, semi-structured interviews were conducted with instructors who integrate gamification elements such as points, levels, progress bars, and immediate feedback i
