Filetype
IMPORTANCE: The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.OBJECTIVE: To evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy.DESIGN, SETTING, AND PARTICIPANTS: Nationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicab
Title: Information Management in Kockums AB’s Supply Chain regarding Development Products – Driving Forces and Barriers to reach excellence
Authors: Fredrik Arborelius and Henrik Stenvinkel
Supervisors: Anders Jansson, Manager Design Support and Tactical Planning, Kockums AB
Dag Näslund, Associate Professor, Department of Industrial Management and Logistics, Lund Institute of Technolog
Tail risk metrics such as VaR and, especially ES are and have become of great importance to both investors and financial institutions such as banks in determining their amount of loss absorbing capital given the Basel framework. Estimating these metrics have become trivial, but to do it accurately while also taking market conditions such as periods of market stress into account still presents chal
Idiopatisk normaltryckshydrocephalus (iNPH) är en neurologisk sjukdom som påverkar hjärnans vätskecirkulation och kan leda till symtom som gång- och balanssvårigheter, kognitiv nedsättning och urininkontinens. Sjukdomen drabbar omkring 1.5 % av 70-åringar, och prevalensen ökar med åldern. Det är en svårdiagnostiserad sjukdom där hjärnvätska (CSF) ansamlas i hjärnans hålrum, vilket påverkar hjärnanIntroduction: Idiopathic normal pressure hydrocephalus (iNPH) is a treatable but largely underdiagnosed neurological condition affecting the elderly population. It is characterised by gait and cognitive impairment, as well as urinary incontinence. For the most part, it is diagnosed via imaging and clinical assessments. Abnormalities in cerebrospinal (CSF) flow in the cerebral aqueduct have been li
Detta examensarbete knyter an till min utbildningsbakgrund, eftersom området som undersökts relaterar till erfarenheter från åren jag studerade klassiskt piano vid Birmingham Conservatoires (B.C.) musikerutbildning. Sedan studietiden i England, upplever jag att när musikstuderande befinner sig i ett främmande land, får de nya perspektiv på varifrån de kommer och börjar ifrågasätta, jämföra och refTitle: The thing with music reading This thesis relates to my educational background, why the studied area connects to experiences from when I studied classical piano performance at Birmingham Conservatoire. Since my time in England, I believe that when music students are situated in a foreign country, they will gain a new perspective on their origin and therefore, start to question, compare and r
Att behandla tumörsjukdomar genom injektion av radioaktiva läkemedel är en behandlingsteknik kallad radionuklidterapi. Det radioaktiva läkemedlet består av en radioaktiv isotop, fäst på en målsökande bärarmolekyl, specifik för den vävnad vari man önskar att läkemedlet skall ansamlas. Då den radioaktiva isotopen sönderfaller sänds joniserande strålning ut; strålning med förmågan att jonisera molekyIntroduction: There is a need of reassessment of radiation absorbed dose specification in nuclear medicine, taking the non-uniformities in the distribution of radioactivity into account. This is especially important in radionuclide therapies where very high activities are administered and the radionuclides emit alpha particles, beta particles or low-energy electron and will require absorbed dose c
Cancer kan drabba vem som helst och kan ha sitt ursprung i många olika områden i kroppen. Antalet nya cancerfall ökar varje år, men vissa typer av cancer har bättre prognos än andra. Den vanligaste cancertypen i Sverige är prostatacancer och den drabbar framför allt äldre män. Prostatacancer har god prognos och det finns effektiva metoder att helt bota prostat- acancer om den behandlas i ett tidigPurpose: Recent developments in external radiotherapy and its utilization with artificial in- telligence (AI) enables advanced treatment plans for a range of different disease sites. By adapting to the anatomy of the day, target coverage can be ensured while sparing more healthy tissue. The purpose of this project was to study the feasibility and benefits of daily cone beam computed tomography (CB
Importance: Preterm delivery has been associated with future cardiometabolic disorders in women. However, the long-term risks of chronic hypertension associated with preterm delivery and whether such risks are attributable to familial confounding are unclear. Such knowledge is needed to improve long-term risk assessment, clinical monitoring, and cardiovascular prevention strategies in women. Objec
There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen
Background: The Influenza – Monitoring Vaccine Effectiveness in Europe (I-MOVE/I-MOVE+) and Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital networks have conducted seasonal multicentre, test-negative, case–control studies in Europe to measure influenza vaccine effectiveness (IVE) since 2015/16. We measured the effect of chronic conditions on VE of influenza A subtypes among older
Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not i
Before performing 177Lu-DOTATATE therapy for neuroendocrine tumors, somatostatin receptor (SSTR) PET imaging is currently used to confirm sufficient tumor SSTR expression, but it also has potential to be used to personalize treatment by predicting absorbed doses to critical organs. This study aims to validate the predictive capability of SSTR PET in anticipating renal absorbed dose in the first cy
Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr
Importance Women with adverse pregnancy outcomes have higher subsequent cardiovascular risks, but their long-term risk of atrial fibrillation (AF) and potential causality are unclear. A better understanding of such risks is needed to identify women with high risk early in life and guide interventions to prevent AF and its complications. Objective To determine long-term risks of AF associated with
Importance: Traditional adoption studies examine disorder-to-disorder parent-offspring transmission. The role of parental genetic risk in offspring disorder transmission can capture indirect genetic effects from parental genotype to parental phenotype to offspring risk. Objective: To assess the relative importance of genetic and rearing effects from paternal family genetic risk scores (FGRSs) in 3
Background Pulmonary nodules (PNs) are clinically challenging because differentiation between benign and malignant PNs is not possible at CT detection; recurring CT examinations and invasive procedures are often required in PN follow-up. Purpose To investigate PN prevalence in a middle-aged population and the risk factors associated with these nodules. Materials and Methods In this secondary analy
Popular Abstract in Swedish Levande organismer, inklusive människor, har en 14C/12C-kvot som återspeglar miljön. När materialet dör slutar kroppen att fylla på 14C och kroppens 14C börjar sönderfalla till 14N. Detta gav upphov till den klassiska 14C-dateringsmetoden, vilken utvecklades av professor W.F. Libby, 1949 och gav honom Nobelpriset i kemi 1960. 14C-datering används huvudsakligen inom arkeThe testing of nuclear weapons in the atmosphere, in the middle of the 20'h century, resulted in a bomb-pulse excess of atmospheric 14C. A bomb-pulse dating method was thus developed. The latter is a method to determine the time of formation of formerly living modern (i.e. living after 1955) material , based on the 14C/ 12C ratio in it. The objective of this work was to evaluate the factors that c
Surrogate measures of safety (SMoS) are meant to function as tools to investigate traffic safety. The term surrogate indicates that these measures do not rely on crash data; instead, they focus on identifying safety critical events (or near-crashes) in traffic, which can be used as an alternative to crash records. The overall aim of this thesis is to explore which SMoS are suitable when analysing
Background/Purpose: The aim of this study was to estimate the incidence rate and prevalence of coronary artery diseases (CAD) in patients with temporal artery positive giant cell arteritis (TAB+GCA) from a defined population in southern Sweden, and to describe characteristics of CAD in this sample.Methods: The study cohort consisted of 1202 patients (71.9% women) diagnosed with TAB+GCA between 199
Background: Potent antithrombotic therapy has significantly improved prognosis for patients with acute myocardial infarction (AMI), however, at a price of increased bleeding risk. Chronic gastric infection with Helicobacter pylori (Hp) commonly causes upper gastrointestinal bleeding and is proposed as a risk factor for subsequent bleeding post AMI. The prevalence of active Hp in a current AMI popu
