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Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This p

We report the first measurements of z -dependent coherent optical transition radiation (COTR) due to electron-beam microbunching at high gains (>10(4) ) including saturation of a self-amplified spontaneous emission free-electron laser (FEL). In these experiments the fundamental wavelength was near 530 nm, and the COTR spectra exhibit the transition from simple spectra to complex spectra (5% spectr

Development of artificial neural network (ANN) models using real plant data for the prediction of fresh steam properties from a brown coal-fired boiler of a Slovenian power plant is reported. Input parameters for this prediction were selected from a large number of available parameters. Initial selection was made on a basis of expert knowledge and previous experience. However, the final set of inp

High-repetition-rate laser-induced fluorescence measurements of fuel and OH concentrations in internal combustion engines are demonstrated. Series of as many as eight fluorescence images, with a temporal resolution ranging from 10 mus to 1 ms, are acquired within one engine cycle. A multiple-laser system in combination with a multiple-CCD camera is used for cycle-resolved imaging in spark-ignition

1. We examined the response to chemical cues from fish and crayfish, two predators with contrasting feeding modes, and their single and combined effect on shell morphology in the freshwater snail Radix balthica. 2. Snails were subjected to four treatments: tench (Tinca tinca), signal crayfish (Pacifastacus leniusculus), a combination of tench and signal crayfish and no predators (control). Shell

A simple electrospinning method is developed to introduce signal transduction ability into molecularly imprinted nanofibers.

Objective Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job

Abstract in French La de´termination du profil de concentration en chlorures dans un be´ton d’une structure soumise a` un environnement marin est une de´marche usuelle pour une pre´diction de la dure´e de service re´siduelle de la structure. Les me´thodes d’e´chantillonnage les plus communes sont le pre´le`vement de poudre par forage ou le carottage a` sec a` profondeurs croissantes pour dosages dInvestigating marine concrete by determining the chloride profile is a common way for making a prediction of the remaining service life of a structure. The most common methods of sampling concrete for this purpose is dust sampling by dry drilling or sampling cores which are analyzed by profile grinding in a laboratory. Now, a similar study has been performed, by simulating different sampling techn

An algorithm for the computation of mode I stress intensity factors of a square crack together with an error estimate is presented. The algorithm is based on a hypersingular integral equation. The leading singular behavior of the crack opening displacement in the corners is taken into account. The maximum value of the normalized stress intensity factor, Fmax, is estimated to Fmax=0.7534±0.0002. Pr

In this work a low power 5th order chebyshev active-RC low pass filter that meets Rel-8 LTE receiver requirements has been designed with programmable bandwidth and overshoot. Designed for a homodyne LTE receiver, filter bandwidths from 700kHz to 10MHz are supported. The bandwidth of the operational amplifiers is improved using a novel phase enhancement technique. The filter was implemented in 65nm

This paper presents a front-end architecture for fully integrated 60 GHz phased array receivers. It employs LO-path beamforming using a phase controlled phase-locked loop (PC-PLL). To demonstrate the architecture a circuit is implemented featuring a two stage low noise amplifier, two cascaded active mixers, and a PC-PLL. The receiver downconverts the 60 GHz signal in two steps, using LO signals fr

No current commercially available myoelectrically controlled prosthetic hands provide conscious sensory feedback to the user. A system aiming at relocation of sensory input from a prosthetic hand equipped with force sensors to the forearm skin of amputees, a tactile display, has been developed and constructed. The system consists of five piezoresistive force sensors or, alternatively, a prosthetic

In this paper we generalize the electricity spot price model of Lucia and Schwartz by a two-factor model with jumps and stochastic volatility. We estimate the model on daily spot price data from the Nordic market using an approach that combines traditional statistical methods with a Markov chain Monte Carlo algorithm. Results show that the model captures most of the trajectorial and the statistica

A nonlinear 3D finite element model and a theoretical parameter study in relation to glued-in rods for timber structures are presented. A strain-softening crack band model was used to characterise the behaviour of the adhesive layer between the rod and the wood. The model is general in the sense that it bridges the gap between the theory of an ideal plastic bondline and the theory of linear elasti