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Background: Escherichia coli, the most common bacterium causing urinary tract infections (UTIs), is increasingly reported as resistant to multiple antibiotics. Swedish surveillance data from hospital and primary health care (PHC) report a 17%-19% prevalence of resistance to ciprofloxacin in E. coli from urine cultures in men over 20 years of age. Surveillance data may include nosocomial infections
We present a novel animal model for rheumatoid arthritis induced with a well defined synthetic adjuvant oil, pristane. Two weeks after a single intradermal injection of 150 microliters of pristane, the rats developed severe and chronic arthritis. The inflammation was restricted to the joints and involved pannus formation, major histocompatibility complex (MHC) class II expression, and T lymphocyte
Most studies of life quality are concentrated on a country-level scale, while local differences within a country or area are less studied. Thus, the effect of the environment on life quality on a local scale remains understudied and is often represented by one generalized common factor. In this study, we investigated the effect of an objectively measured environmental quality variable and subjecti
In recent years, there has been a surge in the development of AI-based Software as a Medical Device (SaMD), particularly in visual specialties such as dermatology. In Australia, the Therapeutic Goods Administration (TGA) regulates AI-based SaMD to ensure its safe use. Proper labelling of these devices is crucial to ensure that healthcare professionals and the general public understand how to use t
Background: Exertional breathlessness is a cardinal symptom of cardiorespiratory disease. Research Question: How does breathlessness abnormality, graded using normative reference equations during cardiopulmonary exercise testing (CPET), relate to self-reported and physiologic responses in people with chronic airflow limitation (CAL)? Study Design and Methods: An analysis was done of people aged ≥
The temporal aspect of groundwater vulnerability to contaminants such as nitrate is often overlooked, assuming vulnerability has a static nature. This study bridges this gap by employing machine learning with Detecting Breakpoints and Estimating Segments in Trend (DBEST) algorithm to reveal the underlying relationship between nitrate, water table, vegetation cover, and precipitation time series, t
Introduction/Background Completetumor resection is the most relevant prognostic factor for overall survival in high grade serous ovarian cancer (HGSOC) patients. The current standard for classification of postoperative residual disease is surgeon´s subjective evaluation at the end of surgery. Thus, a reliable objective predictive marker is currently missing.MethodologyIn this prospective single-ce
BACKGROUND: To clarify, in a national sample, associations between risk for seven psychiatric and substance use disorders and five key transitions in Sweden's public educational system. METHODS: Swedish-born individuals (1972-1995, N = 1 997 910) were followed through 12-31-2018, at mean age 34.9. We predicted, from these educational transitions, risk for major depression (MD), obsessive-compulsiv
A search for the decay of the Higgs boson to a Z boson and a light, pseudoscalar particle, a, decaying respectively to two leptons and to two photons is reported. The search uses the full LHC Run 2 proton–proton collision data at s=13 TeV, corresponding to 139 fb−1 collected by the ATLAS detector. This is one of the first searches for this specific decay mode of the Higgs boson, and it probes unex
Aims The aim of this study was to investigate the potentially increased risk of dislocation in patients with neurological disease who sustain a femoral neck fracture, as it is unclear whether they should undergo total hip arthroplasty (THA) or hemiarthroplasty (HA). A secondary aim was to investgate whether dual-mobility components confer a reduced risk of dislocation in these patients. Methods We
Over the last decade, the growth in demand for green innovations has become apparent. This can be linked to increased consumer awareness of the environmental problems that the world is facing. This review presents the determinants of consumer green innovation adoption across domains identified in marketing literature. We included and synthesized 47 articles published between 2010 and July 2021 in
Background: Whole-genome sequencing (WGS) and whole-transcriptome sequencing (WTS), with the ability to provide comprehensive genomic information, have become the focal point of research interest as novel techniques that can support precision diagnostics in routine clinical care of patients with various cancer types, including hematological malignancies. This national multi-center study, led by Ge
Introduction It is standard of care to provide sedation to critically ill patients to reduce anxiety, discomfort and promote tolerance of mechanical ventilation. Given that sedatives can have differing effects based on a variety of patient and pharmacological characteristics, treatment approaches are largely based on targeting the level of sedation. The benefits of differing levels of sedation mus
Electronic health records (EHRs) are a rich source of information for medical research and public health monitoring. Information systems based on EHR data could also assist in patient care and hospital management. However, much of the data in EHRs is in the form of unstructured text, which is difficult to process for analysis. Natural language processing (NLP), a form of artificial intelligence, h
Abstract Background and Purpose: Members of the Millennial Generation are stereotypically described as job-hoppers, who tend to frequently change jobs after approximately 16 months of employment. This study aims to shed light on the retention management of Millennials in relation to the importance of 360-degree feedback. Focusing on the Millennial Generation, the following two research questions
The European Union’s identity as a normative power has long been examined and contested, most famously by Ian Manners' conceptualization in his 2002 work, Normative Power Europe. This study critically reassesses the EU's proposed identity through the lens of its responses to two pivotal crises: the Syrian conflict (2012-2015) and the 2016 EU-Türkiye Refugee Deal. The research interrogates
Den nuvarande ökningen av icke-statliga aktörer som bedriver kommersiell verksamhet i rymden har lett till juridiska frågor om bland annat ansvar. Är det nuvarande internationella rättsliga ramverket för yttre rymden tillräckligt etablerat för att hantera övergången från ett rättsområde som en gång dominerades av stater, till ett område som idag drivs av privata ekonomiska intressen? I denna uppThe important rise of non-state actors performing commercial activities in outer space has resulted in legal issues regarding inter alia responsibility. The question is whether the current international legal framework on outer space is sufficiently established to cope with a continuously shifting legal area once dominated by States to one today driven by private economic interests. This essay i
The survival of our planet is in crisis, and it is affecting society at large. People recognise companies have significantly contributed to the problem, and stakeholders expect and demand businesses to do better. Nowadays, there are strong arguments in sustainability for engaging with as many employees as possible to find novel and innovative solutions more quickly. This study investigated how a p
