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There are many advantages of combining incretin therapy [glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors] with insulin therapy as a glucose-lowering strategy in type 2 diabetes. One important advantage is the complementary mode of the mechanistic action of incretin and insulin therapy. Another advantage is the reduction in risk of hypoglycemia and we

New technology requirements derived from the exploitation of novel energy resources, and the needs for improvement of the energy efficiency of current power generation systems are pushing the industry towards the search of alternative working fluids. The great challenge for these non-conventional fluids is to provide satisfactory performances and fill the existing lack of media for some innovative

A 12-bit 125-MHz digital-to-analog converter (DAC) for communication application is designed. It is based on current-steering segmented architecture and modified Q2 random walk switching scheme to obtain 12-bit accuracy. A new voltage swing reduced driver (VSRD) is implemented to promote the dynamic performance. The DAC uses 0.18 µm 1.8 V standard digital CMOS technology. The die area (core) is 2.

Despite significant reductions in acute-rejection rates with the introduction of calcineurin inhibitor (CNI)-based immunosuppressive therapy, improvements in long-term graft survival in renal transplantation have been mixed. Improving long-term graft survival continues to present a major challenge in the management of kidney-transplant patients. CNIs are a key component of immunosuppressive therap

This paper presents a Fisher information based Bayesian approach to analysis and design of the regularization and preconditioning parameters used with gradient based inverse scattering algorithms. In particular, a one-dimensional inverse problem is considered where the permittivity and conductivity profiles are unknown and the input data consist of the scattered field over a certain bandwidth. A p

Feedback control has been applied to computing systems, usually taking a designed system and closing a loop to adjust some of its parameters. However, the design of computing systems components as controllers have shown advantages with respect to state-of-the-art techniques, especially in the scheduling domain, where uniprocessor schedulers have been designed as discrete-time control structures. H

Telomeres are natural ends of eukaryotic chromosomes and perform a major role in cell biology. They protect chromosomes from degradation, fusions and the end replication problem. To study telomeres different model organisms are used including a number of yeast species. In this work I present a new species in yeast telomere studies – Saccharomyces castellii. This yeast exhibits a lot of interesting

The paper presents a Matlab toolbox for simulation of real-time control systems. The basic idea is to simulate a real-time kernel in parallel with continuous plant dynamics. The toolbox allows the user to explore the timely behavior of control algorithms, and to study the interaction between the control tasks and the scheduler. From a research perspective, it also becomes possible to experiment wi

This paper presents a dynamic optimization procedure of grade changes of polyethylene production. The optimization is built upon a novel modular Modelica library containing e.g., non-linear DAE models for polyethylene reactors based on models currently used in nonlinear MPC of industrial reactors at Borealis AB. Using Optimica, which extends the Modelica language with constructs for optimization p

Abstract.Over the past decade, a new global regime of anti-corruption has taken shape. Pushed by NGOs such as Transparency International, and with coalitions of international organizations, Western governments, and private business circles, we now have a framework of conventions and regulations that impel governments and international firms to act with integrity and to prevent corruption in busine

This thesis presents studies of molecular motors in interaction with nm-scale structures, as well as the development of a set of tools that can be used for the construction of custom-designed nano-transportation systems. In our studies, we have used the latest nanoscale technology and combined this with advanced results from chemistry and biomedical sciences. We have succeeded in transferring bio