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Demonstration of antibody‐associated cellular cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy

This study demonstrates that a cytotoxic serum reactivity not requiring the presence of complement appears in the sera of patients with acute myelogenous leukemia. The reaction is detected upon short‐term incubation of sera in vitro with autochthonous mononuclear white blood cells from peripheral venous blood of patients at the acute stage of the disease. This reactivity was demonstrated in 18/18

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity

Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients – A PET/MR study

Traumatic brain injury (TBI) and repeated sports-related concussions (rSRCs) are associated with an increased risk for neurodegeneration. Autopsy findings of selected cohorts of long-term TBI survivors and rSRC athletes reveal increased tau aggregation and a persistent neuroinflammation. To assess in vivo tau aggregation and neuroinflammation in young adult TBI and rSRC cohorts, we evaluated 9 hea

The clinical effect of an unloader brace on patients with osteoarthritis of the knee, a randomized placebo controlled trial with one year follow up

Background: Treatment of patients with knee osteoarthritis is challenging. Unloader braces have been developed with various success. Unloader One® Knee Brace is light, easily-fitted and shown to be effective by the unloading of the affected compartment. The aim of the study was to assess the clinical outcome of the brace vs. a placebo on patients with knee osteoarthritis. Methods: Initially 150 pa

Host-pathogen interactions in Streptococcus pyogenes infections, with special reference to puerperal fever and a comment on vaccine development.

Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively

Rod-Shaped Monocytes Patrol the Brain Vasculature and Give Rise to Perivascular Macrophages under the Influence of Proinflammatory Cytokines and Angiopoietin-2

The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endoth

Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation.

Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr

Dry release of suspended nanostructures

A dry release method for fabrication of suspended nanostructures is presented. The technique has been combined with an anti-stiction treatment for fabrication of nanocantilever based nanoelectromechanical systems (NEMS). The process combines a dry release method, using a supporting layer of photoresist which is removed using oxygen ashing in a reactive ion etcher (RIE), with CHF3 plasma induced de

Efficacy of rfixfc versus rix-fp for the treatment of patients with hemophilia b : Matching-adjusted indirect comparison of b-long and prolong-9fp trials

Purpose: In patients with hemophilia B, treatment with extended half-life (EHL) recombi-nant factor IX allows for longer dosing intervals while providing equal or superior bleeding protection compared with standard half-life products. This enables flexible, individualized treatment schedules, which reduce the burden of prophylaxis and improve patient outcomes. This analysis compared the efficacy o

Ungdomshandboll: skadeförebyggande program som fungerar i praktiken – Vetenskap och Hälsa

Ungdomshandboll: skadeförebyggande program som fungerar i praktiken – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Ungdomshandboll: skadeförebyggande program som fungerar i praktiken 2026-02-04 I-PROTECT är ett nytt skadepreventionsprogram för ungdomshandboll i Sverige som utvecklats av f

https://www.vetenskaphalsa.se/ungdomshandboll-skadeforebyggande-program-som-fungerar-i-praktiken/ - 2026-05-21

The power of evaluation

The aim of this special issue is to invite scholars in public administration to address issues of power in relation to evaluation practices in the public sector. Power is one of those big, difficult, and inherently nebulous concepts that both scholars and practitioners appear to consciously or unconsciously avoid. Our ambition in this introduction is not to present a comprehensive conceptual revieThe aim of this special issue is to invite scholars in public administration to address issues of power in relation to evaluation practices in the public sector. Power is one of those big, difficult, and inherently nebulous concepts that both scholars and practitioners appear to consciously or unconsciously avoid. Our ambition in this introduction is not to present a comprehensive conceptual revie

Receptor for IgA in group A streptococci : cloning of the gene and characterization of the protein expressed in Escherichia coli

The gene for an IgA-binding protein from a group A streptococcal strain was cloned and expressed in Escherichia coli. The IgA-binding protein, called protein Arp, was purified on IgA-Sepharose, allowing complete purification in a single step. Analysis of protein Arp by Western immunoblotting demonstrated a major IgA-binding band, with an apparent molecular weight of 42 kD. The purified protein was

Magasin-rev-juni-2020

Exempel på magasin från Lunds universitet Rubrik UNDERTEXT Magasin EXEMPEL MED OCH UTAN GRID Framsida. Framsida. Magasinmallen är A4, vilket är mest ekonomiskt i tryck. LU Innovation 2018 | THE YEAR IN BRIEF | LUND UNIVERSITY Understand, explain, improve THEMATIC COLLABORATIONS | LUND UNIVERSITY LU Innovation 2018 | THE YEAR IN BRIEF | LUND UNIVERSITY Understand, explain, improve THEMATIC COLLABOR

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/magasin-rev-juni-2020.pdf - 2026-05-23

Luvre-058arvidssonmfllosanremoval

Test "Title" ORNIS SCANDINAVICA 15: 63-66. Copenhagen 1984 Removal experiments in a population of Willow Warblers Phylloscopus trochilus in mountain birch forest, in Ammarnas, Swedish Lapland Bjorn Arvidsson and Per Klaesson Arvidsson, B. and Klaesson, P. 1984. Removal experiments in a population of Willow Warblers Phylloscopus trochilus in mountain birch forest, in Ammarnis, Swedish Lapland. - Or

https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-058arvidssonmfllosanremoval.pdf - 2026-05-23