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Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity. Metho
This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo
Background: In healthy hearts, left ventricular atrioventricular plane displacement (LVAVPD) measured by cardiac magnetic resonance (CMR) contributes to ∼60% of stroke volume. LVAVPD has been shown to correlate with maximal cardiac output and exercise capacity and is an independent predictor of outcomes in patients with heart failure. We aimed to assess if longitudinal pumping is altered, if LVAVP
INTRODUCTION: The gold standard for monitoring long-term glucose levels in patients with diabetes mellitus is glycated hemoglobin (HbA1c). In conditions where the erythrocyte half-life is decreased, for example, in long-term kidney diseases and hemoglobinopathies, HbA1C may underestimate the long-term glucose exposure. Therefore, in these patient groups, other methods to monitor long-term glucose
Introduction: The hepatic cytochrome P450 system includes the polymorphic CYP2D6 gene. CYP2D6 ultra rapid metabolizers (UMs) were 10-fold more common in suicide victims than in the general population in a previous study. The aim of this study was to investigate if the occurrence of the CYP2D6 UM genotype differs between subjects with and without previous suicide attempt in patients treated for dep
INTRODUCTION: Despite having few vascular risk factors, people with Down syndrome (DS) have MRI evidence of cerebrovascular disease (CVD) and neuroinflammation that worsens with Alzheimer's disease (AD) severity. We investigated whether markers of CVD and inflammation are associated with AD-related diagnostic progression in people with DS. METHODS: We included 149 participants (mean age [SD] = 44.
Cooperativity is an efficient way for nature to regulate complex processes, allowing for control over a narrower range of concentrations compared to noncooperative phenomena. Here, we investigate the cooperative binding of α-Synuclein to lipid membranes under different conditions, aiming to uncover the underlying molecular driving forces. We interrogate the role of electrostatic interactions by ra
Chans till tidig Alzheimerupptäckt ökar – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Chans till tidig Alzheimerupptäckt ökar 2015-09-17 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Oskar Hansson och Sebastian Palmqvist. Foto: Björn
https://www.vetenskaphalsa.se/chans-till-tidig-alzheimer-upptackt-okar/ - 2026-07-17
Membrane proteins play several important roles in a cell. Among these proteins are aquaporins (AQPs) and transient receptor potential (TRP) ion channels that mediate water transport, temperature and noxious chemical sensation, respectively. The function of some AQPs, for example the spinach isoform SoPIP2;1 is regulated by pH, phosphorylation and heavy metals such as mercury. However, the mechanis
