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Solving problems that are perceptually dissimilar but require similar solutions is a key skill in everyday life. In adults, this ability, termed analogical transfer, draws on memories of relevant past experiences that partially overlap with the present task at hand. Thanks to this support from long-term memory, analogical transfer allows remarkable behavioral flexibility beyond immediate situation
Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.
More than half the world's rainforest has been lost to agriculture since the Industrial Revolution. Among the most widespread tropical crops is oil palm (Elaeis guineensis): global production now exceeds 35 million tonnes per year. In Malaysia, for example, 13% of land area is now oil palm plantation, compared with 1% in 1974. There are enormous pressures to increase palm oil production for food,
Background: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with inflammatory and apoptotic properties. A complex relationship exists between TRAIL and the lung where both elevated TRAIL and TRAIL deficiency are associated with lung impairment. In neonatal mice, TRAIL is thought to translate respiratory infections into chronic lung disease but the association between
Objectives: Assess the relationship of cognitive impairment to disability, accounting for depression severity and frailty, among older adults with late-life depression (LLD). Methods: Data were analyzed from 78 community-dwelling older adults with LLD and without dementia (age M = 71.9; SD = 6.1). Cognitive functioning was assessed using a comprehensive neuropsychological battery. Depression sever
The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively. The yet uncharacterized MTase encoded by the YNL024C gene in Saccharomyces cerevisiae shows high sequence similarity to METTL21A and VCP-KMT, as well as to their uncharacterized paralogues METTL21B and METTL21C. Despite being most
In polyandrous species, fathers benefit from attracting greater maternal investment toward their offspring at the expense of the offspring of other males, while mothers should usually allocate resources equally among offspring. This conflict can lead to an evolutionary arms race between the sexes, manifested through antagonistic genes whose expression in offspring depends upon the parent of origin
BACKGROUND: Pancreatic cancer is a major cause of cancer-related mortality. The identification of effective biomarkers is essential in order to improve management of the disease. Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo pathway, a signal transduction system implicated in tissue repair and regeneration, as well as tumorigenesis. Here we evaluate the biomarker potential
BACKGROUND: Physical activity might reduce the risk of developing dementia. However, it is still unclear whether the protective effect differs depending on the subtype of dementia. We aimed to investigate if midlife physical activity affects the development of vascular dementia (VaD) and Alzheimer's disease (AD) differently in two large study populations with different designs.METHODS: Using a pro
Studies of native syntactic processing often target phrase structure violations that do not occur in natural production. In contrast, this study examines how variation in basic word order is processed, looking specifically at structures traditionally labelled as violations but that do occur naturally. We examined Swedish verb-second (V2) and verb-third (V3) word order-processing in adult native Sw
The European eel Anguilla anguilla Linnaeus 1758 is critically endangered with recruitment estimated at 5–10% of historical levels. Enhancing survival of recruits is pivotal for conservation, and restoration should consider habitat choice of elvers ascending river systems. We experimentally show that newly ascended elvers choose small pebble habitat over finer and larger substrates, regardless of
Contemporary organizations expect newly formed teams to perform from the outset under strict time and task constraints. While Wheelan’s (1994a; 2005) Integrated Model of Group Development (IMGD) frames team development as a progression through distinct stages, few studies have examined whether such assumptions are reflected in the temporal structure of early interaction. Drawing on a dynamic syste
This study examines the relationship between video games exposure and political attitudes among young adults in Sweden. As video games have become one of the most prominent forms of contemporary popular culture and entertainment media, and Sweden ranks as one of Europe’s most founded gaming industries. It is important to understand whether gaming engagement is associated with political socialisati
This thesis explores how young urban Chinese women construct virtual intimate relationships within the context of otome games and related practices, Cosplay commissions and role-play chatting (RPC). By combining autoethnography and semi-structured interviews, the study delves into the emotional practices and gender dynamics that emerge from players’ engagement with virtual romance and semi-virtual
In this following essay, anxiety and different ways of thinking were examined through a questionnaire in an attempt to find a connection between different cognitive styles and anxiety. This resulted in an attempt to find connections between objective, spatial and verbal cognitive styles, and self-perceived anxiety in a population which consisted of highly intelligent people and a control group. Th
During the Secret War in Laos, 1964-1973, the United States dropped approximately 2 million tons of bombs in Laos. However, 30% of the employed bombs failed to detonate. It is estimated that 78 million unexploded ordance (UXO) still contaminate the land of Laos. This paper therefore aims to explore how UXO affect the possibilities for the rural population in Houamoung district to attain a sustaina
When there is a statement of deficiency given to a nursing home, the Centers for Medicare & Medicaid Services (CMS) requires facilities to submit a plan of correction stating how they will create systemic change to prevent recurrence of the incident. This study reviewed 90 statements of deficiency and associated plans of correction from across the United States for abuse, neglect, and exploita
