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Background: The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders characterized by accumulation of autofluorescent material in many tissues, especially in neurons. Mutations in the CLN8 gene, encoding an endoplasmic reticulum ( ER) transmembrane protein of unknown function, underlie NCL phenotypes in humans and mice. The human phenotype is characterized by
Background: Mutations in the PRSS1 gene explain most occurrences of hereditary pancreatitis (HP) but many HP families have no PRSS1 mutation. Recently, an association between the mutation N34S in the pancreatic secretary trypsin inhibitor (SPINK1 or PSTI) gene and idiopathic chronic pancreatitis (ICP) was reported. It is unclear whether the N34S mutation is a cause of pancreatitis per se, whether
BACKGROUND: Knowledge about the social and economical determinants of prescription is relevant in health care systems like the Swedish one, which is based on the principle of equity, and which aims to allocate resources on the basis of need and not on criteria that are based on social constructs. We therefore investigated the association between patient and health care practice (HCP) characteristi
D. Briihl and A. W. Inhoff (1995) found that exterior letter pairs showed no privileged status in reading when letter pairs were presented as parafoveal primes. However, T. R. Jordan, S. M. Thomas, G. R. Patching, and K. C. Scott-Brown (2003) used a paradigm that (a) allowed letter pairs to exert influence at any point in the reading process, (b) overcame problems with the stimulus manipulations u
There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, which is produced by the endocrine cells. In the present study, we show that islets intended for islet transplantation produce tissue factor in both the transmembrane and
This thesis analyzes how digitalization in elderly care affects cost-efficiency and quality of care. More specifically, digitalization in elderly care is divided into welfare technologies and E-services. The study goes into how well digitalization meets its promises of solving many of our society's future problems regarding elderly care, such as an aging population. In order to analyze this, I
The doctrine of joint criminal enterprise (JCE) is a form of individual criminal liability in international criminal law. This doctrine was formed by the Appeals Chamber of the ICTY in the Tadić Case in 1999. Since then, the JCE has grown to play a major role in the charges and convictions before international criminal tribunal. Due to this doctrine, the members who formed the criminal plan are re
In this master thesis it is investigated where the housing shortage that Sweden faces in 2003 comes from. Starting from two alternative scenarios, a scapegoat is looked for: either the industry is responsible for lowering the supply of housing by increasing the cost of dwellings through illegal cartel agreements, or the state is to be blamed for distorting market forces through an inadequate housi
Market failure is a concept invoked in both economics and public policy to justify governmental interventions in the marketplace. Drawing on more than five years of qualitative research on public transport in Stockholm, this paper explores how market failure, operating as a form of folk theory within public policy, informed a legal reform. This reform aimed to reconfigure an established contractua
AIMS/HYPOTHESIS: Several studies have suggested that large fat cells are less responsive to insulin than small fat cells. However, in these studies, large fat cells from obese individuals were compared with smaller fat cells from leaner participants, in effect making it impossible to draw conclusions about whether there is a causal relationship between fat cell size and insulin sensitivity. We hyp
AIMS: This study aimed to investigate the association between the 'Shrunken pore syndrome' (SPS) and risk of death, 30 day rehospitalization, and health-related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatin C /eGFRcreatinine ratio.METHODS AND RESULTS: A total of 373 p
Background: Semi-natural pastures are unfertilized grasslands with a long history of traditional low-input grazing management. This kind of pastures are recognized for their high species richness. However, as a consequence of modernization of agriculture, many of the semi-natural pastures have been lost during the last century, leading to a serious threat to farmland biodiversity. Semi-natural pas
It is increasingly apparent that technology and online platforms entail and communicate normativity. Lawrence Lessig has described this in terms of 'code as law' and thereby pointing to the fact that there is an ongoing shift of power from nation states to tech companies, and José van Dijck has shown how the Big Five - Google (Alphabet), Apple, Amazon, Facebook, Microsoft - represents a neo-libera
Health professions education places significant emphasis on learning in the clinical environment. While experiences of workplace learning have been extensively investigated, practices of workplace learning explored through field work have been less utilized. The theoretical framework of teaching and learning regimes acknowledges aspects of power and conflict in its consideration of what guides tea
The purpose of this study is to quantitatively discover whether green brand knowledge has an effect on the perception of green claims with Swedish Millennial's and Gen Z. As to whether it is perceived as credible or greenwashing. This study builds upon previous brand knowledge and green claim literature. However, where previous research has green brand knowledge as the dependent variable and t
The focus of this bachelor’s essay is to investigate non-lexical interjections. In this study, imitative interjection proves to be an appropriate term for interjections such as mm-hmm and wow, with non-lexical properties distinguishing them from hey and yes. This essay aims to explore if this specific group can be extracted from a corpus, and further, if it is possible to detect any similarities a
This thesis examines the impact of macroeconomic shocks on adolescents health, specifically those aged between 14 and 18 years. Using data from the Youth Risk Behavior Surveillance System (YRBSS) covering U.S. states from 1999 to 2019, this study investigates various health outcomes and behavioural variables among high-school students. A two-way fixed effects model, that accounts for state- and ye
