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Although it is firmly established that endogenous immunity can prevent cancer outgrowth, with a range of immunomodulatory strategies reaching clinical use, most studies on the topic have been restricted to solid cancers. This applies in particular to cancer initiation, where model constraints have precluded investigations of immunosurveillance and immunoediting during the multistep progression int
The notion of firms interacting with technology is not new; these types of systems were already in place in the mid eighties. E-business users worked with connections between their inbound logistics and procurement systems, and suppliers’ order-entry systems. When these connections were described for the first time the vertical links between two, or more, value chains in a value system received mo
The distribution of tau pathology in Alzheimer's disease (AD) shows remarkable inter-individual heterogeneity, including hemispheric asymmetry. However, the factors driving this asymmetry remain poorly understood. Here we explore whether tau asymmetry is linked to i) reduced inter-hemispheric brain connectivity (potentially restricting tau spread), or ii) asymmetry in amyloid-beta (Aβ) distributio
Purpose: This systematic literature review aims to develop a comprehensive understanding of effort as a multidimensional construct in individuals with impaired swallowing and/or spoken communication. Method: A comprehensive literature search was conducted across three data-bases: PubMed/MEDLINE, Embase, and CINAHL, covering publications from 1966 to 2024. The search included terms related to commu
Objective: To investigate whether low daily doses of fluoridated milk, as an adjunct to oral hygiene routines with fluoridated toothpaste, can prevent caries development in enamel and dentine in adolescents. Material and methods: Adolescents (mean age 13 years) at three dental clinics in Sweden were enrolled to a randomised clinical trial (RCT) including baseline and 2-year follow-up examinations.
Visual assessment of medial temporal lobe atrophy (MTA) in the clinical workup of cognitive impairment is traditionally corrected for age since MTA increases with age. In addition, common pathologies in the elderly such as amyloid, tau, alpha-synuclein and TDP-43 accumulation as well as white matter hyperintensities representing small vessel disease may affect the association between MTA and age.
Aims: Testing insulin resistance could help improve physician assessment of patients’ risk of prediabetes or type 2 diabetes (T2D), even among normoglycemic individuals. Methods: The longitudinal study followed 16,333 normoglycemic participants in a nation-wide employer-sponsored health assessment program starting in August 2020 with a median follow-up time of 2.9 years for incident prediabetes or
Self-care is increasingly recognized as a central aspect of mental health recovery, yet its meaning and enactment among individuals who engage in non-suicidal self-injury (NSSI) remain poorly understood. Existing conceptual models emphasize self-care as behavioral regulation, awareness, and autonomy but may overlook the emotional and relational complexities that shape this process in psychiatric c
Objective: Psychiatric comorbidity frequently presents in anorexia nervosa (AN). Yet, the premorbid mental health status is rel-atively unknown. The aim of this study was to map out psychiatric morbidity and psychopathology among girls at familial highrisk (FHR) of developing AN, thereby detecting possible underlying vulnerabilities preceding the disease.Method: Twenty-eight daughters of mothers w
PurposeThe International Labour Organisation (ILO) adopted a new Convention concerning the Prohibition and Immediate Action for the Elimination of the Worst Forms of Child Labour (No. 182) in 1999. The aim of this paper is to analyse the United Nations (UN), ILO, Council of Europe (COE) instruments related to child exploitation and discuss whether child pornography and prostitution are economic cr
Purpose: The purpose of this paper is to investigate the role of Google in everyday online searching activities of Swedish teenagers in different contexts. Design/methodology/approach: The study is qualitative and material has been produced through interviews and observations in two different schools with participants aged 15-16. Goffman’s frame analysis provides the analytical lens for studying h
The objects of Alf Gabrielsson's study Strong experiences with music are experiences and insights that exceed by far what is normally included in music experiences. To a great extent, the many (over 500) experiences related in this book are so intense that a reader often cannot avoid comparing them to her or his own experiences with music. The multi-variety of character in music experiences is vie
Cryptochromes (Cry) have been suggested to form the basis of light-dependent magnetic compass orientation in birds. However, to function as magnetic compass sensors, the cryptochromes of migratory birds must possess a number of key biophysical characteristics. Most importantly, absorption of blue light must produce radical pairs with lifetimes longer than about a microsecond. Cryptochrome 1a (gwCr
Emergency management practice can be supported by ICT in many ways, and numerous ICT-based systems are available that offer support in the different phases of emergency management. Yet, many such systems do not provide as much support to emergency management as expected or wished for. In some situations they may even compromise emergency management performance, due to suboptimal adaptation to the
It has often been argued that the Earth is like an island in space and that its brittleness is most clearly reflected on small islands in the oceans. Easter Island, in particular, with its largely depleted resources, has been seen as a microcosmic warning about what could happen to our entire planet. However, the analogy of the Earth and islands with finite natural resources is not self-evident fr
A plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in human pancreatic islets. A group of coexpressed genes (module), enriched for interleukin-1-related genes, was associated with T2D and reduced insulin secretio
Although treaty interpretation is undoubtedly an activity governed by international law, and by Articles 31-33 of the 1969 Vienna Convention on the Law of Treaties (VCLT) in particular, some commentators continue repeating the pre-Vienna adage that treaty interpretation is a matter of art and not science, the implication of which is that no understanding of a treaty provision can ever be explained
