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Aims: To clarify whether parasympathetic neuropathy in Type 2 diabetic patients is associated with features of the insulin resistance syndrome. Methods: Blood pressures, glycaemic control (HbA(IC)), plasma lipids, residual β-cell function (fasting plasma C-peptide), autonomic nerve function, urinary albumin excretion and glomerular filtration rate (Cr-EDTA clearance) were evaluated in 82 Type 2 di
Urbanization represents a fierce driver of phenotypic change, yet the molecular mechanisms underlying observed phenotypic patterns are poorly understood. Epigenetic changes are expected to facilitate more rapid adaption to changing or novel environments, such as our towns and cities, compared with slow changes in gene sequence. A comparison of liver and blood tissue from great tits Parus major ori
The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8 and Periphilin — contribute to assembly and targeting of the complex remains unknown. Here, we define the biochemical basis of HUSH assembly and find that its modular architecture rese
Background: The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investigate spatial associations between regional tau pathology ([18F]flortaucipir PET), synaptic density (synaptic vesicle 2A [11C]UCB-J PET) and synaptic function (M
Treatment of neuroendocrine tumors with 177Lu-octreotate results in prolonged survival and improved quality of life for the patient. However, the treatment is today limited by side effects on kidney and bone marrow, and complete tumor remission is rarely seen. A possible way to minimize dose-limiting toxicity and to optimize this treatment method is to use radioprotectors in conjunction with radio
Shiga toxin (Stx)-stimulated blood cells shed extracellular vesicles (EVs) which can transfer the toxin to the kidneys and lead to hemolytic uremic syndrome. The toxin can be taken up by renal cells within EVs wherein the toxin is released, ultimately leading to cell death. The mechanism by which Stx is taken up, translocated, and sequestered in EVs was addressed in this study utilizing the B-subu
Eye trackers are sometimes used to study the miniature eye movements such as drift that occur while observers fixate a static location on a screen. Specifically, analysis of such eye-tracking data can be performed by examining the temporal spectrum composition of the recorded gaze position signal, allowing to assess its color. However, not only rotations of the eyeball but also filters in the eye
Psoriatic arthritis (PsA) is a chronic musculoskeletal inflammatory disease found in up to 30% of psoriasis patients. Prolargin—an extracellular matrix (ECM) protein present in cartilage and tendon—has been previously shown elevated in serum of patients with psoriasis. ECM protein fragments can reflect tissue turnover and pathological changes; thus, this study aimed to develop, validate and charac
Background: Chronic Kidney Disease (CKD) is associated with an increased risk for cardiovascular events such as stroke. However, it is still unclear if decreased kidney function is associated with a vulnerable atherosclerotic plaque phenotype. To explore if renal function was associated with carotid plaque vulnerability we analyzed carotid plaques obtained at surgery from the Carotid Plaque Imagin
Chlorophyll is the light-harvesting molecule central to the process of photosynthesis. Chlorophyll is synthesized through 15 enzymatic steps. Most of the reactions have been characterized using recombinant proteins. One exception is the formation of the isocyclic E-ring characteristic of chlorophylls. This reaction is catalyzed by the Mg-protoporphyrin IX monomethyl ester cyclase encoded by Xantha
The aim of this study was to investigate torso cooling benefit of various PCM vests in a simulated warm environment (Ta= 34 °C, RH=56 %, Va=0.4 m/s). A pre-wetted cotton torso fabric skin was used to simulate sweating on a thermal manikin (Tmanikin=34 °C). Six conditions were tested: nude fabric skin (Fabric Skin), Vest A without (VA) and with frozen gels with a melting temperature (Tm) of 0 °C (V
Abstract in Undetermined Whilst it has been established that spontaneous eye movements occur with visual imagery and that they are comparable with those from an original scene inspection (e.g., Brandt & Stark, 1997; Johansson, Holsanova, & Holmqvist, 2006), the exact purpose of these eye movements has been a hot topic of debate (cf., Ferreira et al., 2008; Richardson et al., 2009). Do they
Since the prescription of antibiotics in the hospital setting is often empiric, particularly in the critically ill, and therefore fraught with potential error, we analysed the use of antibiotic agents in Swedish intensive care units (ICUs). We examined indications for antibiotic treatment, agents and dosage prescribed among 393 patients admitted to 23 ICUs at 7 tertiary care centres, 11 secondary
This article aims to undertake a comprehensive cost-benefit analysis of SSAB's investment in green steel production under the HYBRIT initiative, focusing on the implications of operating within the EU Emission Trade System and an illustrative scenario employing a carbon tax. The study evaluates profitability and social benefits, utilizing time series models to forecast electricity prices in di
This article aims to undertake a comprehensive cost-benefit analysis of SSAB's investment in green steel production under the HYBRIT initiative, focusing on the implications of operating within the EU Emission Trade System and an illustrative scenario employing a carbon tax. The study evaluates profitability and social benefits, utilizing time series models to forecast electricity prices in di
How do low carbon transitions in developing economies differ from decarbonization of developed economies? Which specific challenges face developing economies? This thesis discusses the literature on low carbon technology transfers, climate finance and carbon lock-in in developing economies and applies these concepts to the Indian case. The carbon intensity of energy supply is analyzed using the en
This thesis investigates how Armenia’s security dependence on Russia is discursively constructed and maintained through political texts. Analyzing the 1994 and 2020 ceasefire agreements ending the first and second Karabakh war, alongside 18 official statements from the Russian Ministry of Foreign Affairs (2020–2025), the study argues that these texts function not only as records of geopolitical ev
