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BACKGROUND: The CA-125 tumor marker has limitations when used to distinguish between benign and malignant ovarian masses. We therefore establish likelihood curves of six subgroups of ovarian pathology based on CA-125 and menopausal status.METHODS: This cross-sectional study conducted by the International Ovarian Tumor Analysis group involved 3,511 patients presenting with a persistent adnexal mass
Since most models used to study neuronal dysfunction display disadvantages and ethical concerns, a fast and reproducible in vitro model to study mitochondria-related neurodegeneration is required. Here, we optimized and characterized a 3-day retinoic acid-based protocol to differentiate the SH-SY5Y cell line into a neuronal-like phenotype and investigated alterations in mitochondrial physiology an
Objectives:The Multidimensional Dyspnea Profile (MDP) comprehensively addresses dyspnea, incorporating both perceptual and affective components, and has proven effective in assessing breathlessness among patients with chronic lung conditions. Despite its validation in High-Income Countries, its applicability in Low/Middle-Income countries remains uncertain. Additionally, the MDP has not been trans
This paper showcases new research avenues made possible by applying computational methods to historical isiXhosa text. I outline a method for isiXhosa computational text analysis which adapts word frequency analysis to be applied to isiXhosa texts focusing on root words. The paper showcases the value of the approach in a study of emerging political identities in early African nationalism, examinin
Purpose We describe the key elements of early palliative care (PC) across the illness trajectory and examine whether visit content was associated with patient-reported outcomes and end-of-life care. Methods We performed a secondary analysis of patients with newly diagnosed advanced lung or noncolorectal GI cancer (N = 171) who were randomly assigned to receive early PC. Participants attended at le
Programmable optical circuits form a key part of quantum technologies today. As the size of such circuits is increased, maintaining precise control over every individual component becomes challenging. Here we show how embedding an optical circuit in the higher-dimensional space of a large mode-mixer allows us to forgo control over individual elements, while retaining a high degree of programmabili
Background: Family members play a crucial role in supporting women with breast cancer during their recovery. In the complex situation of being an informal caregiver, their own health and ability to support the patient needs to be acknowledged. The aim was to explore the experiences, needs and roles of family members throughout the rehabilitation process of women with breast cancer. Methods: A qual
"Storsjöodjuret”, eller “The Great Lake Monster”, är ett undflyende fenomen i sjön Storsjön, belägen i landskapet Jämtland i norra Sverige. Denna avhandling i ämnet humanekologi undersöker hur det sammankopplingar av det sociala, det kulturella, det historiska och det lokala påverkar formandet av detta svenska kryptid, eller “dolda djur”. Syftet med studien är att visa hur detta vetenskapligt ännuStorsjöodjuret, or The Great Lake Monster, is an elusive phenomenon in lake Storsjön, situated in the province of Jämtland in Northern Sweden. This dissertation in Human Ecology investigates how the intricate web of the social, the cultural, the historical, and the local influence the shaping of this Swedish cryptid, or “hidden animal”. The purpose of the study is to demonstrate how this scientif
This paper aims to explore how four Bolivian small and medium-sized enterprises’ business has overcome the gaps in reliance on traditional small and medium-sized enterprises’ business models, i.e., to extract and sell raw unrefined natural resources in a local area, and instead make productive use of innovation inputs (technology, higher-educated people) by innovating their business models. We wer
Det första skedet när ett byggnadsverk ska uppföras är det konceptuella designskedet, det är här de första besluten om utformningen av byggnadsverket görs. I det traditionella arbetsflödet utformas byggnadsverket först i ett ritprogram, sedan används ett annat datorverktyg för att verifiera att det utformade byggnadsverket kan hantera de krafter som uppstår, t.ex. vind, egentyngd osv. Detta arbeteBefore a new structure can be built, it must be designed. This design phase is a very important step in the building process. The total cost of the structure and its structural performance are largely dependent on the structural design process. The impact of decisions on the design process is initially high and declines as the design matures. However, few computational tools are available for the
False positive recall is a major issue in breast cancer screening and the introduction of artificial intelligence (AI) might affect which women who are unnecessarily recalled. We have investigated how an AI system works on false positive recalls at screening and compared with radiologist findings. Two-view digital mammography (DM) examinations from 656 recalled women (136 with screening detected c
Dyspnea is a common and highly distressing symptom in patients with advanced illnesses. Many patients continue to experience chronic dyspnea despite optimal management of underlying disease(s) and various non-pharmacologic interventions, necessitating the consideration of pharmacologic therapies for palliation of dyspnea. One commonly asked question by clinicians is whether benzodiazepines have a
Little is known about pediatric surgical disease in resource-poor countries. This study documents the surgical care of children in central Haiti and demonstrates the influence of the 2010 earthquake on pediatric surgical delivery. METHODS: We conducted a retrospective review of operations performed at Partners in Health/Zanmi Lasante hospitals in central Haiti. RESULTS: Of 2,057 operations p
En lantmäteriförrättning vars syfte till största del är att undvika stämpelskatt kallas “skatteförrättning”. Genom reglerna i FBL kan köpare av fast egendom i vissa situationer undkomma reglerna kring lagfart i JB och därmed undvika stämpelskatt för förvärvet. I aktuella situationer är köparen ägare av en fastighet till vilken det tänkta köpeobjektet regleras. Skattelättnaden är i sig inget hindA cadastral procedure with the intent to avoid paying stamp duty for particular real estate transactions is a well-known phenomenon in Sweden. By using the rules in the Property Formation Act stamp duty can be avoided. In order to comply with the rules in the Property Formation Act the buyer has to already own real estate, to which the recently acquired land parcel can be transferred. The Cadastra
Denna uppsats redogör för straffvärdebedömningen vid grova narkotikabrott. Fram till 1923 hade narkotika ingen juridisk innebörd i Sverige, men allteftersom det introducerades i samhället och ett missbruk började spridas, började också lagstiftningen utvecklas kring det. När det uppdagades vilka rusframkallande och beroendeframkallande effekter narkotika förde med sig, och att dessa preparat hamnaThis essay describes the assessment of penal value concerning grave narcotic offenses. Up until 1923 narcotics did not have a legal meaning in Sweden, but as it was introduced in society and an addiction started spreading, the legislation also started to evolve around it. When it began to be known what intoxicative and addictive effects narcotics brought with it, and that these preparations starte
Populärvetenskaplig sammanfattning:Elfordon uppfattas ofta som en modern uppfinning, men elektriskt drivna fordon har funnits sedan slutet av artonhundratalet. De första helelektriska personbilarna, bussarna och lastbilarna utvecklades redan innan förbränningsmotorn slog igenom.För att förstå varför elektriska störningar spelar en så viktig roll i dagens elfordon kan man börja med en enkel bild. TThe rapid electrification of heavy-duty vehicles has introduced traction voltage systems (TVS) with electrical scale and complexity not previously seen in on-road applications. Multiple power electronic subsystems interact through long cables and frequency-dependent impedances, making conducted electromagnetic interference (EMI) a system-level phenomenon. Differential-mode (DM) and common-mode (CM
Background: Ensuring that national governance and healthcare systems include the organization and provision of palliative care in all care settings for all patients in need is a global imperative. In cancer care, early palliative care can improve quality of life for patients and families and receiving specialised palliative care increases opportunities for care and death in the preferred place, wh
In Thinking Like a Climate: Governing a City in Times of Environmental Change, Hannah Knox offers a new ethnographic study of the local dynamics of climate change, focusing on the city of Manchester. This detailed analysis of local climate politics illustrates the need for a wholesale reconfiguration of how we think about human-nature relations and act collectively to make the world a better place
Background: Physiologically guided revascularization improves clinical outcomes. The cutoff values for deferral with fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the same across all coronary arteries, despite differences in coronary flow patterns. The objective was to compare deferral rates using either FFR or iFR in the right coronary artery (RCA), left anterior desce
Introduction The recognition of breathlessness in clinical practice appears suboptimal, despite its prevalence and impact. This study aimed to explore the content of clinical conversations about breathlessness and patients’ level of self-reported openness when discussing their breathlessness. Methods A cross-sectional, online survey of Australian adults (≥18 years) stratified to the 2016 National
