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Botulinum neurotoxins (BoNTs), the most potent toxins known, are potential bioterrorism agents. It is well established that all seven serotypes of BoNTs (BoNT/A-G) require complex gangliosides as co-receptors. Here, we report that BoNT/DC, a presumed mosaic toxin between BoNT/D and BoNT/C1, binds and enters efficiently into neurons lacking complex gangliosides and shows no reduction in toxicity in
The Absolut Company har öppnat besökscentret Absolut Home i Åhus och detta har potential att medföra ett stort antal värden för orten. Forskarna har studerat bådeturistaktörers och Åhusbors syn på värden för att ta reda på hur de ställer sig till det nya besökscentret i sin ort.
The differences between two standard Monte Carlo models, LEPTO and ARIADNE, for deep inelastic scattering at small-χ is analysed in detail. It is shown that the difference arises from a 'unorthodox' suppression factor used in ARIADNE which replaces the normal ratio of parton densities. This gives rise to a factor that qualitatively is similar to what one would expect from BFKL dynamics for some ob
PIXE is nowadays a routine analytical technique in the study of atmospheric aerosols. If it aspires to continue to be so in the future, it will have to compete with a range of other powerful analytical techniques, and outperform them in some respect. It will be shown how PIXE can indeed play an important role in future studies of atmospheric aerosols. For clarification, two concrete examples will
The production of continuously distributed X-rays by the impact of protons of 1.9-3.0 MeV for X-ray energies between 4 and 6.5 keV, and 1.9-2.65 MeV for X-ray energies between 1.7 and 4 keV has been investigated. Five different target types have been irradiated: polyethylene, polystyrene, carbon. KaptonTM and MylarTM. The results are presented as absolute cross sections for continuous X-ray produc
The fourth version of the Ariadne program for generating QCD cascades in the colour dipole approximation is presented. The underlying physics issues are discussed and a manual for using the program is given together with a few sample programs.The major changes from previous versions are the introduction of photon radiation from quarks and inclusion of interfaces to the LEPTO and PYTHIA programs.
We report magnetic properties and relative paleointensity (RPI) proxies from a suite of 10 conventional piston cores and Kasten cores from the SW Iberian Margin collected during cruise JC089 of the RSS James Cook in August 2013. Mean sedimentation rates are in the 10–20 cm/kyr range. Age models were acquired by correlation of Ca/Ti and Zr/Sr XRF core-scanning data to L* reflectance from the Cariac
Along with the review of the technological frame that will be available at the Extreme Light Infrastructure Attosecond Light Pulse Source (ELI-ALPS) we present considerations applicable to large-scale attosecond sources driven by high-power laser pulses.
Background: The aim of this study was to identify predictors of outcome after septoplasty in 888 patients from the Swedish National Septoplasty Register. Methodology: This is an observational register study analysing data from patients undergoing septoplasty in Sweden between 2015 and 2016. The patients reported severity of nasal obstruction (mild, moderate, severe) pre- and again 12 months postop
Although researchers across the social sciences speak of a linguistic turn, most research exploring culture still assumes a traditional perspective on language, which conceives meaning as representation. Yet, Wittgenstein convincingly criticized the epistemological basis of such a perspective, offering an alternative view on language. The paper begins by explaining the central points of a performa
In this study the capacity of towed floating electrical imaging for mapping a known aquifer recharge zone in more detail is investigated. A 50 km reach of the Namoi River, Australia, was surveyed. The river is perched up to 16 m above an unconfined aquifer that extends to 30 m below the ground surface. The unconfined aquifer overlies a semi-confined aquifer system. The electrical array consists of
A series of comparative studies is suggested, focused on perceptions of outrigger canoes, and aimed at an increased understanding of the relationship between social relations, biodiversity, and sustainable development in Oceanic societies on small islands and in coastal areas undergoing rapid cultural change. After a critique of the recent notion that canoe-building in Polynesia developed as a res
Abstract not available.
With the advent of the Functional Mock-up Interface (FMI) standard, exchanging dynamic models between modeling and simulation tools has been greatly simplified. At the core of it, FMI is a standardized and unified model execution interface for dynamic models. FMI has gained widespread adoption among users and numerous commercial and open source tools implement support for the standard. In this art
Specimens of large fungi (mushrooms) were screened for mutagenic activity by the Salmonella/microsome assay, with strains TA98, TA2637 and TA100. Out of 48 species tested, 37 exhibited a significant but for the most part weak activity. The activity observed in the presence of S9 mix was typically between 0 and 50% of that without, and in no case was the activity increased in the presence of micros
