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Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate-binding proteins, including extracellular matrix prote
CD59 is a glycosylphosphatidylinositol (GPI)-anchored cell surface inhibitor of the complement membrane attack complex (MAC). We showed previously that CD59 is highly expressed in pancreatic islets but is down-regulated in rodent models of diabetes. CD59 knockdown but not enzymatic removal of cell surface CD59 led to a loss of glucose-stimulated insulin secretion (GSIS), suggesting that an intrace
Carbon sequestration in arable soils is gaining increasing attention in global policymaking initiatives for climate-change mitigation. Large-scale assessments of soil organic carbon development in arable land are affected by the scarcity of reliable time series of soil organic carbon monitoring data and often fail to replicate observed trends or appreciate any effects induced by changes in soil ma
Background: Studies on risk factors for severe COVID-19 in people of working age have generally not included non-working persons or established population attributable fractions (PAFs) for occupational and other factors. Objectives: We describe the effect of job-related, sociodemographic, and other exposures on the incidence, relative risks and PAFs of severe COVID-19 in individuals aged 18–64. Me
Within international investment law scholarship, increased attention has been devoted to the capacity of international investment law, which includes investment treaty arbitration, to facilitate sustainable development. Scholars increasingly agree that issues of sustainable development permeate throughout the international investment law system and thus cannot be viewed as beyond its scope and jur
Purpose – This study aims to explore how an accessibility database (AD) has been developed and implemented as a tool for facility managers to evaluate and increase the accessibility of public facilities.Design/methodology/approach – Eight participants were strategically sampled for semi-structured interviews, and documents on the AD were gathered. The Consolidated Framework for Implementation Rese
We assessed the structure and content of a new scale, the SHEPS, to assess change in sexual health confidence, knowledge and attitudes in nursing and midwifery students following an intervention (a 2-day standardized workshop on sexual health). Students were 78 Tanzanian nursing and midwifery students attending a University of Health Sciences, who were assessed immediately before and after the wor
We describe the presumably first intentional ABO-incompatible deceased-donor kidney and pancreas transplantation with a severe antibody-mediated rejection during a rebound of isoagglutinins. Rejection was successfully treated with eculizumab, which inhibits the terminal pathway of complement. Complement analysis (C3, C3d,g, and a modified assay of classical complement-related hemolytic function) d
The Alzheimer’s Association and the Society of Nuclear Medicine and Molecular Imaging convened a multidisciplinary workgroup to update appropriate use criteria (AUC) for amyloid positron emission tomography (PET) and to develop AUC for tau PET. Methods: The workgroup identified key research questions that guided a systematic literature review on clinical amyloid/tau PET. Building on this review, t
Purpose: Internet-delivered cognitive behavioral therapies and lifestyle interventions are promising for reducing psychiatric symptoms in cancer survivors, but little is known about the contribution of specific treatment components to observed effects. A randomized factorial trial could allow for evaluation of the unique contribution of treatment components to overall treatment effects. The IN-FAC
BackgroundShock is a condition with high mortality even with early intervention and treatment. Usual care for shock and hypotension in the Emergency Department (ED) is intravenous fluid resuscitation which can lead to fluid overload and other complications. When fluid therapy fails or risk of complications are high, the next treatment step is the use of vasopressors for stabilisation. Noradrenalin
Radiation dosimetry and cancer risk estimations are central to virtually all radiation safety applications, optimization, and research. These estimates relate to various exposure situations including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new methodology to handle the dosimetry of an acute/single intake of radionu
BACKGROUND: Drug use Disorder (DUD), the risk for which is substantially influenced by both genetic and social factors, is geographically concentrated in high-risk regions. An important step toward understanding this pattern is to examine geographical distributions of the genetic liability to DUD and a key demographic risk factor - social deprivation.METHODS: We calculated the mean family genetic
INTRODUCTION: The Alzheimer's Association and the Society of Nuclear Medicine and Molecular Imaging convened a multidisciplinary workgroup to update appropriate use criteria (AUC) for amyloid positron emission tomography (PET) and to develop AUC for tau PET. METHODS: The workgroup identified key research questions that guided a systematic literature review on clinical amyloid/tau PET. Building on
To mitigate ongoing insect biodiversity declines, there is a need for efficient yet accurate monitoring methods. The use of traditional catch-based survey methods is constrained both by costs and need for expertise for manual taxonomic identification. Emerging methods, such as eDNA and robotic sorting, have the potential to reduce workload but still require resource-intensive sample collection in
For Alligator Bioscience AB, a company developing immunotherapeutic antibodies, it is crucial to efficiently evaluate a large number of potential drug candidates at an early stage. The in-house developed RUBYTM concept, combining monoclonal antibodies into bispecific antibodies without lead optimization, requires implementation of high-throughput technologies. Restriction enzyme digestion, used fo
Matematikcentrum Matematik och Numerisk Analys NF Sammanställning för MATA31 Envariabelanalys, VT 2025 Kursinformation Kursansvarig: Anders Olofsson Övriga lärare: Antal studenter: 85 nyregistrerade samt 2 omregistrerade. 24 studenter har svarat på utvärderingen varav 18 har läst denna kurs inom kandidatprogrammet i fysik, teoretisk fysik, astronomi eller sjukhusfysik. 1 student har läst kursen in
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/VT2025/MATA31VT25.pdf - 2026-07-02
Microsoft Word - HILMA NY.doc 1 HILMA Historiska Institutionen i Lund Meddelar Att… Årgång 28, 2002/03, Nr 3, 2002 10 22 SEMINARIER OCH UNDERVISNING Se Gula schemat. De närmast aktuella seminarierna är: 24/10 Victor Lundberg: Lantbrukare Per Isaksson och den postmoderna utmaningen (ver.1.2). Ordf: Lars Edgren. OBS: Plats Konferensrummet. Uppsatsen utlagd. 29/10 Stefan Nyzell: Upplopp! I de skötsam
https://www.hist.lu.se/fileadmin/_migrated/content_uploads/hilma_ht02_3_03.pdf - 2026-07-02
Microsoft Word - Allm best_08-09.doc Innehåll Innehåll ................................................................................................................................ 1 Allmänna föreskrifter och upplysningar .............................................................................. 2 Arkitektutbildningen .........................................................................
https://www.lth.se/fileadmin/lth/anstallda/utbildningsadministration/studiehandbok/SHB_2008-09.pdf - 2026-07-03
