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Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline ho
The use of large language models (LLMs) is being explored for a multitude of tasks in software engineering (SE), ranging from code generation to bug report assignment. Although LLMs provide impressive results, they require more time and energy than some other machine learning models. For some tasks, simpler models may be more sustainable than LLMs. In this paper, we construct natural language clas
In this study, a serial production system consisting of two machines and an intermediate finite buffer is considered. The machines have random processing times, and each machine contains one unit of a common critical component that is subject to random breakdown. Broken components must be replaced from an inventory of ready-for-use spare parts to restore machine functionality. This inventory is re
This editorial introduces the special feature’s main objective: to provide latest research findings on the dynamics between environmental protection and post-conflict peacebuilding processes after internal armed conflicts. In the feature, we propose a broad understanding of environmental peacebuilding that takes all cycles of the peacebuilding process into account and puts stronger emphasis on the
PurposeBlockchain technology (BCT) is a novel and disruptive innovation that can transform procurement processes in various industries, including the food sector. BCT can offer benefits such as transparency, traceability, security, and efficiency for procuring food products, which are essential for ensuring food security and quality. However, BCT faces several challenges that hinder its adoption a
The Polarization and Impedance Controlled Car (PICC) presents an innovative approach for demonstrating and teaching key principles of electromagnetic field theory, specifically polarization and impedance. Designed as an interactive learning tool, the PICC utilizes a radio-controlled car, NanoVNA, Raspberry Pi, and handheld antennas to visualize real-time effects of polarization and impedance. The
The effects of the simultaneous presence of monopole and quadrupole pairing interactions on the fission barriers for heavy and superheavy elements are considered. The first barrier for light Thisotopes is found to be raised by 1 MeV, while heavier actinide nuclei seem to be less affected by the inclusion of quadrupole pairing. For the superheavy elements, the inclusion of quadrupole pairing tends
Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mec
This thesis investigates the volatility structures found in forward-looking fundamental valuations of the Swedish stock index OMXS30. The evaluated data constitutes daily observations of P/E ratios based on twelve months earnings estimates during the period 2009-01-02 until 2018-10-18. The analysis is conducted by applying a GARCH modelling framework to a log-return transformed return series deriv
The aim of this empirical study was to find out which characteristics, behaviors, and drives high-performing women have in common in order to illuminate why they have become successful in their work. The aim also included getting insights into some of the challenges that these women meet. Participants were fifteen high-performing women who work in business and academia in Sweden. Semi-structured,
Sub Saharan African (SSA) countries are facing severe economic challenges such as high trade costs, poor trade performance and low growth levels. As a result development assistance is needed to overcome these difficulties. SSA countries receive the highest share of Aid for Trade (AfT) and therefore it is important to assess the effects of AfT. This study investigates the trade effect of AfT on tra
A method is presented for the determination of complex-valued compression and shear elastic moduli of polymers for ultrasound applications. The resulting values, which are scarcely reported in the literature, are found with uncertainties typically around 1% (real part) and 6% (imaginary part). The method involves a setup consisting of a cm-radius, mm-thick polymer ring glued concentrically to a di
This paper analyzes if patients’ demand for Direct-to-Consumer Telemedicine (DCT) providers is affected by a change in patient fees. The paper utilizes a natural experiment when the patient fee increased for patients in Region Stockholm using one DCT provider but remained unchanged for other DCT providers. By using DCT visits per month for all other regions as control, the effect on the demand for
The combined global emergence of a sustainable development discourse and Swedish policies requiring municipalities to rapidly build new housing have led Lund to develop Brunnshög. This pioneering megaproject balances urban expansion with high sustainability ambitions. Through the lens of urban political ecology, this thesis aims at analysing Brunnshög’s dominant sustainability narrative as told by
The ability to hear is essential for receiving auditory signals, which serve as warnings and alerts in many situations, including fire evacuation. However, people with hearing impairments may miss out such signals and can be exposed to dangerous situations. This is particularly relevant in scenarios where audible alarms are the primary form of alert, such as in fire scenarios, natural hazards, or
ADHD is a common neurodevelopmental disorder that is defined by a pattern of hyperactivity and/or inattention that negatively affects an individual’s ability to function in everyday life. There are a multitude of challenges in correctly diagnosing ADHD. Symptoms are primarily behavior based and there are not any good biomarkers that can be used to help clinicians to diagnose the disorder correctly
