Filetype
The need for dedicated fixtures for flexible manufacturing systems is increasing, as dedicated fixtures are lighter, more compact, and more accurate than flexible fixtures. The main challenges are that parts and processes are becoming more and more complex, which requires designing novel or complex dedicated fixtures, and that, for one given flexible fixture to be replaced, several variants of suc
Gene therapy has reached the forefront of studies and research over the last 30 years because of its potential for curing, treating, and preventing diseases associated with DNA mutations. Type 1 and type 2 diabetes are two examples of very common polygenic and multifactorial diseases. The huge amount of scientific literature on this topic reflects a growing general interest in the possibilities of
Unlike most neurodegenerative disorders, individuals at risk from Huntington's disease can be identified prior to the onset of clinical signs of the disease by virtue of it being an autosomal dominant condition. This provides the hypothetical opportunity to delay disease onset and/or slow down the progression of the disease in the very early stages ahead of overt features of disease. To help prepa
The built environment accounts for a significant share of energy consumption and energy efficiency in this sector is important for the Swedish environmental objectives. Only a limited share of the total new construction of multifamily houses are constructed as low-energy buildings. Current building regulations lay down requirements for energy efficiency for new construction, and these will be tigh
Reduction of the anticancer trans platinum(IV) prodrug JM335 by thiols in a moderately alkaline aqueous perchlorate medium is quite rapid and yields trans-[Pt(OH)2(c-C6H11NH2)(NH3)] as the reaction product. The mechanism of reduction involves reductive attack by thiol or thiolate on one of the mutually trans chloride ligands, leading to the formation of a chloride-bridged activated complex.The red
SynopsisOn the basis of kinetic studies of the manganese-catalyzed autoxidation of sulfite and thermodynamic data for iron−manganese redox processes and manganese(II) and -(III) protolysis equilibria, the catalytically active species in the autoxidation is concluded to be a mixed-valence oxo-bridged manganese(II,III) complex. Iron−manganese synergism and triggering of the chain reaction by small c
PurposeThe paper aims to provide a conceptual map of how to mediate between sustainability theory and practice in higher education and how disciplinary divides can be bridged. It further looks at issues linked to knowledge views and drivers for institutional change that affect opportunities for whole institution development promoting action preparedness.Design/methodology/approachTaking its point
An automated ECG-based method may provide diagnostic support in the management of patients with acute coronary syndrome. The Olson method has previously proved to accurately identify the culprit artery in patients with acute coronary occlusion. Methods The Olson method was applied to 360 patients without acute myocardial ischemia and 52 patients with acute coronary occlusion. Results This study es
Salinization is recognized as a threat to soil fertility worldwide. A challenge in understanding the effects of salinity on soil microbial communities is the fact that it can be difficult to disentangle the effects of salinity from those of other variables that may co-vary with salinity. Here we use a trait-based approach to identify direct effects of salinity on soil bacterial communities across
Studies conducted in historical populations and developing countries have evidenced the existence of clustering in infant deaths, which could be related to genetic inheritance and/or to social and cultural factors such as education, socioeconomic status or parental care. A transmission of death clustering has also been found across generations. One way of expanding the knowledge on intergeneration
Big Data Applications (BDAs) manage so much data to require a cluster of machines for computation and storage. Their execution often has temporal constraints, such as deadlines to process the data. BDAs are executed within Big Data Frameworks (BDFs), that provide mechanisms to automatically manage the complexity of the computation distribution. For a BDA to fulfill its deadline when executed in a
OBJECTIVES: To compare 6 minute walking distance (6MWD) in a population-based osteoarthritis (OA) cohort with matched peers from the general population, and to explore the associations between walking ability and CVD risk (arterial stiffness) in the OA cohort.DESIGN: This cross-sectional study included participants (40-80 years) who self-reported OA (n=500) in a population-based study and age- and
The dynamics of ethanol production/consumption in baker's yeast were studied under feed- rate controlled conditions. The yeast was grown on molasses in an 8-l fed-batch reactor and experiments were done at cell concentrations between 5 and 65 g l−1. Small changes in the feed rate were made around a feed rate corresponding to the critical growth rate, at which the yeast cell metabolism switches bet
The ever-increasing consumption of natural resources required for the production of consumer electronics, and the growing amount of electronic waste, underline the importance and urgency of extending the lifespan and use of such products. Information and Communication Technology (ICT) remanufacturing is a growing industry, which nonetheless faces several barriers. Consumers often have a perception
The TRE3 research project focuses on the development of a new and innovative timber frame wall modulus for emergency housing facilities. The wall modulus, in this paper referred to as Hybrid Timber Frame (HTF) wall system, is an evolution of the traditional Light-Frame Timber (LFT) structural systems and combines the advantages and some peculiar aspects of lightweight structures to the potentialit
Incorporating both ecosystem services and disservices into land-use decisions is essential for meeting conservation and livelihood goals. We discuss the merits and challenges of this concept, termed net effects, for birds in agroecosystems. Although birds have widely documented impacts on agriculture (e.g., pest control, crop damage), the net effects of such activities are rarely quantified. This
Background: Animal models of human diseases are often used in biomedical research in place of human subjects. However, results obtained by animal models may fail to hold true for humans. One way of addressing this problem is to make animal models more similar to humans by placing human tissue into animal models, rendering them chimeric. Since technical and ethical limitations make neurological dis
