Filetype
New therapeutic agents for haemophilia with inhibitors that are in development or already licensed are expected to provide transformative treatment options. Many of these new therapies are not based on simply replacing the missing factor; new strategies include bispecific antibody technology that mimics factor VIII coagulation function (emicizumab), and inhibition of anticoagulant proteins such as
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of methylxanthine administration on the incidence of apnea and longer-term clinical outcomes in preterm infants including infants at risk for or having apnea and preterm infants peri-extubation.
Stem cell therapy using human skin-derived neural precursors holds much promise for the treatment of stroke patients. Two main mechanisms have been proposed to give rise to the improved recovery in animal models of stroke after transplantation of these cells. First, the so called by-stander effect, which could modulate the environment during early phases after brain tissue damage, resulting in mod
Unsatisfactory indoor air quality (IAQ) can result from emissions of volatile organic compounds from the materials of the building. A surface emissions trap (cTrap) can be used to stop such emissions thus preventing them from reaching the indoor air. The present study concerned an apartment where the tenants experienced skin and mucous membrane irritation due to moisture-driven emissions from the
We examine a two-dimensional Coulomb gas consisting of n identical repelling point charges at an arbitrary inverse temperature β, subjected to a suitable external field. We prove that the gas is effectively localized to a small neighbourhood of the droplet – the support of the equilibrium measure determined by the external field. More precisely, we prove that the distance between the droplet and t
Most commercial prosthetic hands lack closed-loop feedback, thus, a lot of research has been focusing on implementing sensory feedback systems to provide the user with sensory information during activities of daily living. This study evaluates the possibilities of using a microphone and electrotactile feedback to identify different textures. A condenser microphone was used as a sensor to detect th
Safety, perceived and real, is essential for the attractiveness of urban environments (Avraham & Ketter, 2008, Coaffee & van Ham, 2008, Avraham, 2009). A high degree of perceived safety of a place plays a large role in attracting retail businesses, personnel, and customers. However, perceived safety is not an isolated issue, but related to many aspects, such as the planning of city space,
The Nordic feminist perspectives in law have traditionally been relatively successful in advocating, and effectuating, a feminist perspective of justice both within law and the society. However, Nordic feminist perspectives of law have at least to some degree, at this stage been limited to questions of equality between men and women and to the production of justice within the boundaries of the nat
This article studies the maximum likelihood estimates of magnitude and scale parameters for a Gaussian process of Ornstein-Uhlenbeck type used to model a deterministic function that does not have to be a realisation of an Ornstein- Uhlenbeck process. Specifically, we derive explicit expressions for the limiting values of the maximum likelihood estimates as the number of observations increases. The
The concept of food sovereignty is primarily taken as an alternative to the prevailing neoliberal food security model. However, the approach has hitherto not received adequate attention from policy makers. This could be because the discourse is marked by controversies and contradictions, particularly regarding its ability to address the challenges of feeding a rapidly growing global population. In
Active prechamber spark-ignition engines are a feasible and effective solution in reducing fuel consumption and pollutant emissions for internal combustion engines. However, reliable and low-cost numerical approaches need to be developed to support and speed-up their industrial design, considering their geometric complexity and the involved multiple-flow length scales. In this work, a computationa
We show that in contrast to the conventional view of a mean-field Landau-type behavior, the oxygen octahedral tilt (R) and polarization (P) in the A3B2O7 Ruddlesden-Popper hybrid improper ferroelectric (Ca,Sr)3Ti2O7 exhibits the scaling behavior of a 2D Ising class near the para-to-ferroelectric transition temperature (Tc). We also show that P exhibits an additional transition from a 2D Ising to a
Food loss and waste are major issues in the food industry, and they affect all stages of the food supply chain (FSC). Food loss and waste are linked to environmental deterioration, economic loss, and an increase in hunger. Therefore, the food industry requires sustainable consumption and production (SCP) to reduce losses and waste. The circular economy (CE) concept has become a popular strategy fo
Lung neuroendocrine neoplasms (NEN) are a heterogeneous population of neoplasms with different pathology, clinical behavior, and prognosis compared to the more common lung cancers. The diagnostic work-up and treatment of patients with lung- NEN has undergone major recent advances and new methods are currently being introduced into the clinic. These Nordic guidelines summarize and update the Nordic
Closed-loop motion planning is suitable for obstacle avoidance in dynamically changing environments due to its reactive nature, and various methods have been presented to provide (almost) global convergence. A common assumption in the control design is that the robot operates in a disjoint star world, i.e., all obstacles are strictly starshaped and mutually disjoint. However, in real-life scenario
The Swedish Armed Forces (SwAF) air dive tables are under revision. Currently, the air dive table from the U.S. Navy (USN) Diving Manual (DM) Rev. 6 is used with an msw-to-fsw conversion. Since 2017, the USN has been diving according to USN DM rev. 7, which incorporates updated air dive tables derived from the Thalmann Exponential Linear Decompression Algorithm (EL-DCM) with VVAL79 parameters. The
