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Complement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide on Neisseria meningitidis as an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization and killing. In this study we demonstrate that N. g
BACKGROUND: The aim of this study was to evaluate the efficiency of captopril renography to detect renovascular hypertension (RVH) using the standardized test criteria established at the consensus conference in Santa Fe 1995. The evaluation was made prospectively and in a clinical situation. METHODS: Renal scintigraphy was performed with Tc-MAG3 according to a 2-day protocol in patients receiving
The muscles of the pharynx are controlled by networks of neurons under the control of specific regions in the brain stem, which have been fairly well studied. However, the transmission between these neurons and the pharyngeal muscles, at the motor end plates, is less well understood. Therefore, an in vitro model for the study of neuromuscular transmission in the pharyngeal muscle of the mouse was
The liver is a common location of both primary and secondary malignancies. For unresectable liver cancer, many local ablative therapies have been developed. These include e.g., percutaneous ethanol injection (PEI), percutaneous acetic acid injection, radiofrequency ablation (RFA), cryoablation, microwave ablation, laser-induced thermotherapy, and high-intensity focused ultrasound. RFA has recently
Aim: Tumour stage is the most important prognostic factor in colon cancer. The aim of this study was to examine the impact on the quality of pathology by the use of a standardized PAD protocol. Method: A standardized PAD protocol for colorectal cancer was developed and all patients subjected to colon resection due to adenocarcinomas between 2004 and 2006 were analyzed concerning lymph node status,
Three different SPE sorbents (weak cation exchange, mixed cation exchange, and hydrophobic-lipophilic balance polymers) were compared in terms of recovery, precision, and the effect of matrix components on analyte response for the determination of fluoroquinolones antibiotics. The influence of ethylenediaminetetraacetic acid disodium salt (Na(2)-EDTA) was as well tested. Two of the sorbents, hydro
We propose an integrated framework for the design of SOC test solutions, which includes a set of algorithms for early design space exploration as well as extensive optimization for the final solution. The framework deals with test scheduling, test access mechanism design, test sets selection, and test resource placement. Our approach minimizes the test application time and the cost of the test acc
The investigation of periodic motions of constrained multibody systems requires the numerical solution of differential-algebraic boundary value problems. After briefly surveying the basics of periodic motion analysis the paper presents an extension of projected collocation methods [6] to a special class of boundary Value problems for multibody system equations with position and velocity constraint
In this article, we consider the propagation problem inside a waveguide filled with a homogeneous bi-isotropic material. The cross section of the waveguide is assumed arbitrary. By using the classical theory for the 2D Helmholtz equation in the cross section and the null-field approach, we obtain the dispersion equation in an implicit form. The final equation is a potential candidate for the solut
Release planning for incremental software development assigns features to releases such that most important technical, resource, risk and budget constraints are met. The research presented in this paper is an element of a three-staged procedure. In addition to an existing method for (i) strategic release planning that maps requirements to subsequent releases and (ii) a more fine-grained planning t
BACKGROUND: The importance of voltage-dependent conductances in sensory information processing is well-established in insect photoreceptors. Here we present the characterization of electrical properties in photoreceptors of the cockroach (Periplaneta americana), a nocturnal insect with a visual system adapted for dim light. RESULTS: Whole-cell patch-clamped photoreceptors had high capacitances and
We present the theoretical calculations of the electronic isotope shift factors of the 5d76s24F9/2→(odd,J=9/2) line at 247.587 nm, that were recently used to extract nuclear mean square radii and nuclear deformations of iridium isotopes [Mukai et al. (2020)]. The fully relativistic multiconfiguration Dirac-Hartree-Fock method and the relativistic configuration interaction method were used to perfo
The oleaginous yeast Yarrowia lipolytica is an emerging host for production of fatty acid-derived chemicals. To enable rapid iterative metabolic engineering of this yeast, there is a need for well-characterized genetic parts and convenient and reliable methods for their incorporation into yeast. Here, the EasyCloneYALI genetic toolbox, which allows streamlined strain construction with high genome
current strategies of primary stroke and cardiovascular disease prevention are aimed at addressing the main risk factors primarily in patients with higher cardiovascular disease risk. Since the number of people with incident stroke and ischaemic heart disease cases is rapidly growing across all countries of the world, this preventive strategy appears to be not sufficiently effective. World Stroke
In this paper we consider the case of planar motion, where a mobile platform equipped with two cameras moves freely on a planar surface. The cameras are assumed to be directed towards the floor, as well as being connected by a rigid body motion, which constrains the relative motion of the cameras and introduces new geometric constraints. In the existing literature, there are several algorithms ava
Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of
Plastics play an essential role in modern society, but also lead to significant impacts on the environment and climate. Reducing such impacts while retaining the usefulness of plastics requires a shift towards a more circular and sustainable plastics system. This report tells the story of plastics, and their effect on the environment and climate, and looks at their place in a European circular eco
The energy gap of correlated Hubbard clusters is well studied for one-dimensional systems using analytical methods and density-matrix-renormalization-group (DMRG) simulations. Beyond 1D, however, exact results are available only for small systems by quantum Monte Carlo. For this reason and, due to the problems of DMRG in simulating 2D and 3D systems, alternative methods such as Green functions com
