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Aims/hypothesis. Islet cell autoantibodies are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. Standardisation of islet cell antibodies and the uniform reporting in International units is critical to research and the development of assays for islet cell autoantibodies as diagnostics. Methods. The suitability of a candidate serum to serve as the international standard for islet
We describe a novel monoclonal antibody raised towards the N-terminus of the 65 kDa isoform of glutamate decarboxylase (GAD65). This N-GAD65 mAb is highly specific for GAD65 and can be used in a wide range of applications such as Western blot analysis, immunoprecipitation and immunocytochemistry. Full-length cDNAs coding for N-GAD65 mAb heavy and light chains were cloned and characterized by nucle
Self-other similarity judgment asymmetry refers to the tendency of people to judge others to be more similar to themselves than they judge themselves to be similar to others. This effect can be explained with both a cognitive model (Tversky, 1977) and a motivational explanation (Codol, 1987). Recent research has provided initial evidence for the core assumption of the motivational explanation and
In the present study, the authors reevaluated the temporal course and properties of neurotrophic activities present in the fluid accumulating in the silicone-chamber model for nerve regeneration. The fluid collected from silicone chambers was tested in four different dissociated neuronal cell cultures. Furthermore, the activity of the chamber fluid was examined, using a cell blot technique. There
In the nerve regeneration silicone chamber model, the regenerate which forms across a 10-mm gap between proximal and distal nerve stumps is a monofascicular structure with an outer perineurial-like cell sheath. Recent work has provided indications that the geometry of the regenerate within a silicone chamber can be altered by experimental modifications of the chamber matrix. In the present study w
Path integration is a widespread navigational strategy in which directional changes and distance covered are continuously integrated on an outward journey, enabling a straight-line return to home. Bees use vision for this task-a celestial-cue-based visual compass and an optic-flow-based visual odometer-but the underlying neural integration mechanisms are unknown. Using intracellular electrophysiol
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess whether heparin treatment (both UFH and LMWH) in preterm and term newborn infants with diagnosed thrombosis reduces the rate of mortality and morbidity. The intervention will be compared to placebo or no treatment. In addition, the safety of heparin therapy (both UFH and LMWH) will be assessed for
Purpose The purpose is to develop a framework for measuring the S&OP process performance. Design/methodology/approach The method used is a multiple case study of five companies from different industries based on data from twelve structured interviews. Findings The main result is a framework to measure the S&OP process. It includes concrete suggestions for organizations when developing me
The laminar burning velocity is a fundamental property of combustiblemixtures important for kinetic model validation as well as for practicalapplications. Many efforts are directed towards its accurate determination.The heat flux method is one of the commonly recognized methodsfor measuring laminar burning velocity, however, the information on theaccuracy of the method is scattered in the literatu
Erythroid cell commitment and differentiation proceed through activation of a lineage-restricted transcriptional network orchestrated by a group of well characterized genes. However, the minimal set of factors necessary for instructing red blood cell (RBC) development remains undefined. We employed a screen for transcription factors allowing direct lineage reprograming from fibroblasts to induced
The collection of chapters in this book present the concept of matched filters: Response characteristics “matching” the characteristics of crucially important sensory inputs, which allows detection of vital sensory stimuli while sensory inputs not necessary for the survival of the animal tend to be filtered out, or sacrificed. The individual contributions discuss that the evolution of sensing syst
We argue that social robots should be designed to behave similarly to humans, and furthermore that social norms constitute the core of human interaction. Whether robots can be designed to behave in human-like ways turns on whether they can be designed to organize and coordinate their behavior with others’ social expectations. We suggest that social norms regulate interaction in real time, whereage
The illegal use of pharmacologically active compounds for growth promotion in food-producing species poses risks for consumer health and animal welfare. Surveillance relies on the quantification of drug residues in animal fluids or tissues, but the efficacy can be negatively affected due to undetectable residual concentrations in biological matrices. Consequently, techniques focusing on the indire
According to the European Commission (EC)(2009), the ageing society is one of the grand challenges of our time, and European researchers are encouraged to cooperate to contribute to the knowledge development required to turn the challenges into sustainable solutions. All countries in Europe face similar problems, but there are also marked differences based on cultural and socio-economic diversity
It is demonstrated that an accurate approximation of the screening function is crucial for a quantitative evaluation of the XPS asymmetry index α. It is also shown that the dynamical aspects of the valence electron response are important in order to get an accurate description of the XPS spectrum at finite distances from the threshold.(23 refs)
Multiple sequence alignment is the foundation of many important applications in bioinformatics that aim at detecting functionally important regions, predicting protein structures, building phylogenetic trees etc. Although the automatic construction of a multiple sequence alignment for a set of remotely related sequences cause a very challenging and error-prone task, many downstream analyses still
The article provides an overview of ongoing research and key characteristics of Cognitive Semiotics, an emerging field dedicated to the transdiciplinary study of meaning, involving above all researchers from semiotics, linguistics, developmental and comparative psychology and philosophy. The combination of the following features distinguishes it from other synthetic approaches: (a) integration of
