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Structural properties of the acidic proline rich protein PRP-1 of salivary origin in bulk solution and adsorbed onto a negatively charged surface have been studied by Monte Carlo simulations. A simple model system with focus on electrostatic interactions and short-ranged attractions among the uncharged amino acids has been used. In addition to PRP-1, some mutants were considered to assess the role
Acute otitis media (AOM) is the most common reason for outpatient antimicrobial therapy. Mixed infections pose a potential problem, since the first-line drug used for the treatment of AOM, amoxicillin, can be neutralized by ß-lactamase-producing pathogens of the upper respiratory tract. To study the effects of a 5-day course of amoxicillin on a mixed middle ear infection, rats were challenged with
We found that engagement of beta (2) integrins on human neutrophils induced activation of RhoA, as indicated by the increased ratio of GTP:GTP + GDP recovered on RhoA and translocation of RhoA to a membrane fraction. The clustering of beta (2) integrins also induced a time-dependent increase in GDP bound to RhoA, which correlated with beta (2) integrin-induced activation of p190RhoGAP. The activat
A previous study reported the ability of staphylococci to bind heparin and heparin-dependent host growth factors. The present study isolated and identified heparin- and basic fibroblast growth factor (bFGF)-binding surface components of S. epidermidis strain RP12 and S. haemolyticus strain SM 131. The staphylococcal heparin-binding component(s) were purified by affinity chromatography on heparin-S
In this investigation, the modulating effects of non-immune human IgG and rheumatoid factors (RFs) on antigen-antibody complexations were studied. Non-immune human IgG, as well as RF, were found to inhibit the binding of antigen to specific antibodies of both human and rabbit origin. In addition, human immunoglobulins were also able to modify the composition of preformed antigen-antibody complexes
Protein-polymer association in solution driven by a short-range attraction has been investigated using a simple coarse-grain model solved by Monte Carlo simulations. The effect of the spatial distribution of the hydrophobic surface residues of the protein on the adsorption of weakly hydrophobic polymers at variable polymer concentration, polymer length, and polymer stiffness has been considered. S
The aqueous gallium(III)-acetate system was studied in 0.6 M Na(Cl) at 25 degreesC using a multi-technique approach, including potentiometry, IR spectroscopy, EXAFS spectroscopy and molecular orbital calculations. The potentiometric data were satisfactorily explained by a model which includes one mononuclear and one binuclear complex. The corresponding equilibrium constants defined according to th
This paper presents data from the Austronesian language Seediq, spoken in taiwan, which has both VOS order and final particles. It will be argued that the coccurrence of these two features is unexpected under a pre-antisymmetric analysis, whereas it is easily captured under an analysis couched in Kayne's Antisymmetry model, under the assumption that VOS order is derived by raising the predicate to
Agarose gels have long been known to produce exceptionally large enhancements of the water H-1 and H-2 magnetic relaxation rates. The molecular basis for this effect has not been clearly established, despite its potential importance for a wide range of applications of agarose gels, including their use as biological tissue models in magnetic resonance imaging. To resolve this issue, we have measure
Interreligious dialogue and conversion are two intriguing components in understanding religion. A reading of George Lindbeck constitutes the starting point for a discussion in this paper. The dominant reading of Lindbeck is that he claims that traditions absorb the world. According to this reading of Lindbeck, religious traditions are isolated, and yet the one with the best capacity to assimilate
Abstract is not available
Lightweight walls and floors are often designed as frameworks of studs with plates on each side - a double-plate structure. The free wave-modes and periodic wave motion of a double-plate system reinforced by joists are analysed in the present paper (as the insertion loss and impact sound insulation have been studied in previous papers). The free wave-modes can in a future step be used in connectio
Abstract in UndeterminedSo-called fitting-attitude analyses or buck-passing accounts of value have lately received much attention among philosophers of value. These analyses set out from the idea that values must be understood in terms of attitudinal responses that we have reason to or that it is fitting or that we ought to have regarding the valuable object. This work examines to what extent this
