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We consider gamma-ray bursts (GRBs) produced by the merger of a massive white dwarf with a neutron star. We show that these are likely to produce long-duration GRBs, in some cases definitely without an accompanying supernova, as observed recently. This class of burst would have a strong correlation with star formation, and occur close to the host galaxy. However, rare members of the class need not
The distribution of a semiflexible chain in the volume of two interconnected spherical cavities of equal size has been investigated by using Monte Carlo simulations. The chain possessed an extension exceeding that of the cavity, leading to large probabilities of translocated states despite the entropic penalty of passing the narrow passage. Furthermore, an asymmetric state with unequal subchain le
HAMLET is a protein-lipid complex that selectively kills tumor cells. In this thesis, we identified new mechanisms, whereby HAMLET initiates and executes tumor cell death. HAMLET targets several cellular compartments ranging from the plasma membrane to the nucleus. HAMLET rapidly binds to the plasma membrane of tumor cells and the resulting changes in membrane shape and lipid composition activate
Varicose veins (VVs) have been associated with venous thromboembolism (VTE), but whether these diseases share familial susceptibility has not been determined. This nationwide study aimed to determine whether VTE shares familial susceptibility with VVs.
Abstract Top Background Members of the Peroxisome Proliferator Activated Receptor, PPAR, subfamily of nuclear receptors display complex opposing and overlapping functions and a wide range of pharmacological and molecular genetic tools have been used to dissect their specific functions. Non-agonist bound PPARδ has been shown to repress PPAR Response Element, PPRE, signalling and several lines of ev
Asset integrity and management is an important part of the oil and gas industry especially for existing offshore structures. With declining oil price, the production rate is an important factor to be maintained that makes integrity of the structures one of the main concerns. Reliability based and risk- based inspection (RRBI) constitutes an efficient method to optimize inspection planning. Basing
This paper focuses on a reliability analysis of an offshore wind turbine support structure which is part of an assessment and monitoring framework for wind turbines in operation. The reliability analysis builds upon structural, loading, limit state and uncertainty models comprising design, production and erection data. This model basis facilitates the reliability analysis of the ultimate, the fati
The individual failure of nation states to combat crime (in particular transnational crime) has led to the adoption of international, regional and bilateral legal frameworks for police and judicial cooperation in criminal matters between states. It is widely recognized that transnational criminal activities weaken the ability of states to maintain security within their own boundaries. Yet whilst t
The dynamical formation of black hole binaries in globular clusters that merge due to gravitational waves occurs more frequently in higher stellar density. Meanwhile, the probability to form intermediate mass black holes (IMBHs) also increases with the density. To explore the impact of the formation and growth of IMBHs on the population of stellar mass black hole binaries from globular clusters, w
Research and development of novel molecular compounds in the pharmaceutical industry can be highly costly. Lack of confidentiality can prevent a product from being patented or commercialized. As an effect, cross-organizational collaboration is virtually non-existent. In this paper, we introduce a blockchain-based solution to the collaborative drug discovery problem so that participants can maintai
This policy report focuses on religion-state relations in Georgia and argues that competition between the Eastern Orthodox Church, the Armenian Apostolic Orthodox Church and the Muslim community have had an impact on state involvement with humanitarian programmes. The Georgian case stands out as the country experienced three waves of internal forced displacement. Each wavehas shown that religious
Objectives To explore how mandatory reporting to the supervisory authority of suicides among recipients of healthcare services has influenced associated investigations conducted by the healthcare services, the lessons obtained and whether any suicide-prevention-related improvements in terms of patient safety had followed. Design and settings Retrospective study of reports from Swedish primary and
The argument and discussion in this paper begins from the premise that Hume was an atheist who denied the religious or theist hypothesis. However, even if it is agreed that that Hume was an atheist this does not tell us where he stood on the question concerning the value of religion. Some atheists, such as Spinoza, have argued that society needs to maintain and preserve a form of “true religion”,
Homelessness is a growing global problem. Homelessness produces and reinforces social exclusion. The main reason for homelessness is that there is a shortage of housing available to people with low incomes. Counteracting homelessness requires housing policy initiatives that make it possible for people with low incomes to have access to housing. At the same time people who are homeless must receive
Austrian artist and director of ZKM Center for Art and Media in Karlsruhe, Germany, Peter Weibel (Odessa, 1944), curates a book/catalogue of the mythical exhibition Sound Art, Sound as Medium of Art, that took place between March 2012 and February 2013 in Karlsruhe, with nearly one thousand images of sound art pieces. Along with a very detailed historical trace of sound as a form of art, the book
We discuss a new scenario for the formation of intermediate mass black holes (IMBHs) in dense star clusters. In this scenario, IMBHs are formed as a result of dynamical interactions of hard binaries containing a stellar-mass black hole (BH), with other stars and binaries. We discuss the necessary conditions to initiate the process of intermediate mass BH formation and the influence of an IMBH on t
