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Genotype–phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for continuous phenotypes, is particularly well suited for detecting and characterizing heterogeneous genotype–phenotype associations. Here, we propose a computationa
INTRODUCTION: Acute unilateral vestibulopathy (AUVP), or vestibular neuritis, disrupts the vestibulo-ocular reflex (VOR), leading to impaired gaze stability during head movements. Vestibular function typically recovers to some extent. However, if recovery is incomplete, corrective eye saccades must compensate for the deficient VOR function. The aim was to analyze the progression of VOR gain recove
Popular Abstract in Swedish Jordens dotter. Selma Lagerlöf och den tyska hembygdslitteraturen. Avhandlingen undersöker mottagandet av Selma Lagerlöfs verk i Tyskland åren runt sekelskiftet 1900. Selma Lagerlöf introducerades på den tyska bokmarknaden 1896 med en översättning av debutverket Gösta Berlings saga. Redan tidigt under sin litterära karriär uppmärksammades hon i tysk press och nådde på This dissertation studies the reception of the works of the Swedish author Selma Lagerlöf in Germany at the turn of the century 1900. Selma Lagerlöf was introduced into the German book market in 1896, with a translation of her first novel, “The Saga of Gosta Berling”. She was well received by the German press and had after only a couple of years managed to get herself an impressive readership, whi
Popular Abstract in Swedish Traditionellt har effekten av behandling inom kärlkirurgi främst utvärderats med objektiva mått, som till exempel beräkning av ankelindex och gångsträcka. Dessa data ger värdefull information men de återger inte hur patientens klarar sitt dagliga liv eller hur behandling återverkar på deras livskvalitet. Detta styrks i tidigare forskning som visar att korrelationen mellThe aim of this thesis was to assess quality of life in patients with varying degrees of lower limb ischaemia before and after revascularisation, to assess quality of life in relation to the degree of ischaemia and the respondents’ sense of coherence (SOC) and in comparison with a healthy control group, and to compare two different quality of life instruments regarding their usefulness as outcome
Popular Abstract in Swedish Doktorsavhandling undersöker hur förutsättningar i hemmet, självreglering, akademisk självbild och målorientering påverkar läsförmåga. Att kunna läsa bra är grundläggande för att kunna fungera väl i det moderna samhället där man måste kunna läsa komplicerade texter. Då larmrapporter, kring hur många ungdomar som slutar skolan utan att kunna läsa och skriva, regelbundet The studies in this doctoral thesis investigated how home literacy, self regulation, academic self-concept, and goal orientation influence reading ability. Study 1 investigated the effect of family-based prerequisites, reading attitude, and self-regulated learning on reading ability. Students (n= 4,018) in the eighth grade answered the IEA reading literacy test and the SRLQ. Structural Equation Mo
Popular Abstract in Swedish Bakgrund Avsikten med denna studie har varit att värdera om det idag föreligger tecken som tyder på att utvecklingen av diagnostiska hjälpmedel och behandlingsmetoder vid cancer i bukspottkörteln har åtföljts av en förbättrad prognos, samt att värdera vilken roll rökning och magsårsoperation kan ha för uppkomsten av sjukdomen. Pancreascancer, cancer i bukspottkörteln, The objective of this thesis has been to assess whether there are indications suggesting that new methods for diagnosis and treatment of pancreatic carcinoma (PCa) has been followed by an improved prognosis, and to assess the possible role of smoking and gastric resection in the causation of the disease. Of the 1,200 new cases PCa diagnosed in Sweden yearly, the majority are older than 70 years,
Laser-induced fluorescence for remote imaging of historical monuments is an established technique, which in this work has been used in measurement campaigns at the Coliseum and the Baptistery of San Giovanni in Laterano in Rome, Italy. The results presented here are examples that show that biodeteriogens can be monitored and that. materials can be identified. Also, cleaned and soiled areas on the
Physicochemical properties of solutions of charged colloids are often dominated by the electrostatic interactions present in such systems. A full determination of these properties constitutes a highly nontrivial many-body problem involving long-range interactions. In electrostatically strongly coupled systems, it is essential to explicitly include both the charged colloids and the small ions in th
We are living in a highly dynamic, human-dominated Earth System in which non-linear, abrupt and irreversible changes are not only possible but also probable. These changes require institutional structures capable of steering human society away from critical tipping points and irreversible change and ensuring sustainable livelihoods for all. We see 2012 as a charter moment, a historic opportunity t
Multimeric lactosides based on carbohydrate scaffolds with valencies ranging from 1 to 4 and different linker lengths were synthesized by a copper-catalyzed azide-alkyne cycloaddition (CuAAC). The binding affinities and crosslinking abilities of the new "click clusters" toward biologically relevant galectins (gal-1, gal-3) and peanut lectin were evaluated by fluorescent polarization assay (FPA) an
Purpose - H2O, CO2 and CO are three main species in combustion systems which have high volume fractions. In addition, soot has strong absorption in the infrared band. Thus, H2O, CO2, CO and soot may take important roles in radiative heat transfer. To provide calculations with high accuracy, all of the participating media should be considered non-gray media. Thus, the purpose of this paper is to st
Chromosomal rearrangements (e.g., fusions/fissions) have the potential to drive speciation. However, their accumulation in a population is generally viewed as unlikely, because chromosomal heterozygosity should lead to meiotic problems and aneuploid gametes. Canonical meiosis involves segregation of homologous chromosomes in meiosis I and sister chromatid segregation during meiosis II. In organism
Purpose: To provide a focused review of sickle cell retinopathy in the light of recent advances in the pathogenesis, multimodal retinal imaging, management of the condition, and migration trends, which may lead to increased prevalence of the condition in the Western world. Methods: Non-systematic focused literature review. Results: Sickle retinopathy results from aggregation of abnormal hemoglobin
This essay reflects on issues surrounding the remembrance and teaching of the Holocaust. It was commissioned by the project Living History and the Swedish Prime Minister's Office.
Purpose - The dimple is adopted into a double wall cooling structure which is widely used in hot gas components to increase the heat transfer effects with relatively low pressure drop penalty. The purpose of this paper is to study the effect of dimple depth and dimple diameter on the target surface heat transfer and the inlet to outlet friction factor. Design/methodology/approach - The study is ca
